在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GNAO1 Antibody

  • 中文名稱:
    GNAO1兔多克隆抗體
  • 貨號:
    CSB-PA009593GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    DKFZp686O0962 antibody; G alpha o antibody; G protein alpha 0 antibody; Galphao antibody; GNAO 1 antibody; GNAO antibody; GNAO_HUMAN antibody; GNAO1 antibody; Go alpha antibody; Guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O antibody; Guanine nucleotide binding protein alpha activating polypeptide antibody; Guanine nucleotide binding protein G(o) subunit alpha antibody; Guanine nucleotide-binding protein G(o) subunit alpha antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human GNAO1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.
  • 基因功能參考文獻:
    1. first report of siblings of opposite sex harboring the same GNAO1 mutation but showing differences in phenotype with pronounced dystonia in the boy and epilepsy in his sister. PMID: 28628939
    2. GNAO1 transcription was inhibited by promoter hypermethylation, contributing to its low expression. It was further revealed that the silencing effect was regulated by methyltransferase 1 (DNMT1), and was further enhanced by transforming growth factor beta (TGF-beta). PMID: 29709639
    3. Taken together, the data presented here suggest that TLR2 activation in human mast cells promotes the release of inflammatory mediators via distinct signaling pathways that partially depend on the action of Go proteins. PMID: 27515449
    4. Study identified distinct biochemical mechanisms of pathogenic human GNAO1 mutations that may improve the understanding of the heterogeneous clinical spectrum of GNAO1-associated epilepsy and movement disorders. Furthermore, these results also carry significant implications for personalized therapeutics in GNAO1 encephalopathies. PMID: 28747448
    5. The neurological phenotypes associated with GNAO1 mutations appear to lie on a spectrum, and it is possible that the c.607G>A (p.Gly203Arg) variant characterizes a phenotype with both severe epilepsy and chorea. PMID: 28202424
    6. authors report 2 cases of brothers with a severe movement disorder and hypotonia without epilepsy who have been confirmed by whole exome sequencing to have a novel mutation in GNAO1 PMID: 26060304
    7. Phenotypic spectrum of novel GNAO1 variants in four unrelated female patients included epileptic encephalopathy and involuntary movements with severe developmental delay. PMID: 25966631
    8. GNAO1 is a disease-causing gene for the autosomal dominant form of early infantile epileptic encephalopathy. The novel pathogenic variant identified in should contribute to our understanding of the expanding spectrum of infantile-onset epilepsy. PMID: 26485252
    9. Endothelial cells in capillary malformations are enriched for GNAQ mutations and are likely responsible for the pathophysiology underlying capillary malformation. PMID: 26368330
    10. Galphao-R243H has a mild decrease in nucleotide affinity that causes rapid nucleotide turnover and subsequent hyperactivity in cancer PMID: 24982418
    11. Genetic variants of BCL2, GNAO1, and CHD2 are associated with non-obstructive azoospermia risk. PMID: 24549219
    12. the present study is the first to demonstrate that GNAO1 is overexpressed in GC and that its overexpression correlates with poor prognosis, as it promotes gastric cancer cell viability. PMID: 24366063
    13. Down-regulation of GNAO1 increases cell proliferation, while suppressing the senescence of hepatocellular carcinoma cells. PMID: 23984917
    14. These data suggest that aberrant Galphao signaling can cause multiple neurodevelopmental phenotypes, including epileptic encephalopathy and involuntary movements. PMID: 23993195
    15. CKbeta8- and CKbeta8-1-induced activation of ERK1/2 is mediated by the G(i)/G(o) protein, PLC, and PKCdelta. PMID: 20097574
    16. a novel role in the signal transduction of thrombin receptors in HMECs (human microvascular endothelial cells) that regulates calcium signaling and cytoskeletal rearrangements PMID: 12039967
    17. study suggests that one of the functions of Goalpha in the brain is to mediate extracellular signal-regulated kinase activation by G protein-coupled receptors PMID: 12911629
    18. Activated Goalpha interacted directly with PLZF, and enhanced its function as a transcriptional and cell growth suppressor. PMID: 18262754
    19. the successful purification of functionally intact Gbeta5-free recombinant RGS11 was reported that differentially interact with R7BP and Galpha(oa). PMID: 19497306

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Epileptic encephalopathy, early infantile, 17 (EIEE17); Neurodevelopmental disorder with involuntary movements (NEDIM)
  • 亞細胞定位:
    Cell membrane. Membrane; Lipid-anchor.
  • 蛋白家族:
    G-alpha family, G(i/o/t/z) subfamily
  • 數據庫鏈接:

    HGNC: 4389

    OMIM: 139311

    KEGG: hsa:2775

    STRING: 9606.ENSP00000262493

    UniGene: Hs.644524



主站蜘蛛池模板: 国产人妻大战黑人第1集| 色午夜一av男人的天堂| 国内精品久久久久影院薰衣草| 男人天堂2018亚洲男人天堂| 成人无码视频免费播放| 婷婷色婷婷开心五月四房播播| 99e久热只有精品8在线直播| 亚洲综合色婷婷六月丁香宅男大增 | 自拍区小说区图片区亚洲| 色婷婷五月综合欧美图片| 亚洲成a人片在线观看中文无码 | 日韩精品无码一区二区三区| 国产精品情侣呻吟对白视频| 色婷婷国产精品高潮呻吟av久久| 国产高清露脸孕妇系列| 中文字幕亚洲欧美在线不卡| 国产在线精品一区二区不卡麻豆| 亚洲欧美日韩二三区在线| 思思久久精品一本到99热| 国内精品久久久久久久小说| 2018av天堂在线视频精品观看| 国产高清卡1卡2卡3麻豆| 国产精品无码翘臀在线看| 熟妇人妻系列aⅴ无码专区友真希| 欧美xxxxx高潮喷水麻豆| 色综合亚洲一区二区小说| 人妻体验按摩到忍不住哀求继续 | 日韩精品久久久久久久电影蜜臀| 人妻出轨av中文字幕| 大伊香蕉精品视频在线直播| 久久精品国产导航| 国产熟女亚洲精品麻豆| 奇米影视色777四色在线首页| 藏春阁福利视频| 又污又爽又黄的网站| 狠狠色老熟妇老熟女| 国产老妇伦国产熟女老妇高清| 久久人人爽人人爽人人片| 久久综合给合久久国产免费| 中文在线天堂а√在线| 欧美精品亚洲精品日韩传电影|