在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GNAI3 Antibody, FITC conjugated

  • 中文名稱:
    GNAI3兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA009591LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GNAI3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    87U6 antibody; FLJ26559 antibody; G protein alpha inhibiting 3 antibody; G(i) alpha 3 antibody; G(i) alpha-3 antibody; GNAI3 antibody; GNAI3_HUMAN antibody; Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 antibody; Guanine nucleotide binding protein G(k) alpha subunit antibody; Guanine nucleotide-binding protein G(k) subunit alpha antibody; OTTHUMP00000013368 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Guanine nucleotide-binding protein G(k) subunit alpha protein (1-354AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. Stimulates the activity of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
  • 基因功能參考文獻:
    1. magnetic field-dependent nuclear magnetic resonance relaxation analyses were used to investigate the structural and dynamic properties of GDP bound Galpha on a microsecond timescale. PMID: 28223697
    2. Results show that Galphai3 nuclear translocation causes irradiation resistance in human glioma cells through its complexation with DNA-PKcs leading to DNA repair. PMID: 28456783
    3. GNAI3 is identified a second gene possibly responsible for X-linked ocular albinism. PMID: 27607449
    4. Data show that auriculo-condylar syndrome (ACS)-associated mutations in G protein subunit alpha i3 (GNAI3) produce dominant-negative Galpha(i3) mutant proteins that couple to endothelin type A receptor (ET(A)R). PMID: 27072656
    5. In postmortem human prefrontal cortex, adenosine A1 receptor is coupled preferentially, if not exclusively, to Galphai-3. PMID: 26213104
    6. transcriptional upregulation of Girdin expression and Girdin-Galphai3 signaling play crucial roles in regulating epithelial apicobasal polarity through the PAR complex. PMID: 25977476
    7. GIV and its substrate Galphai3 are recruited to active integrin complexes PMID: 26391662
    8. We demonstrate that the GNAI3 variant is the likely cause of auriculocondylar syndrome in the original ACS1 family. PMID: 25026904
    9. Both SH2 and GEF domains of GIV are required for the formation of a ligand-activated ternary complex between GIV, Galphai3, and EGFR. PMID: 25187647
    10. Low GNAI3 expression is associated with hepatocellular carcinoma. PMID: 25444921
    11. Data indicate that dynein- and astral microtubule-mediated transport of Galphai/LGN/nuclear mitotic apparatus (NuMA) complex from cell cortex to spindle poles. PMID: 23389635
    12. The phenotypic variability of auriculocondylar syndrome suggests that mutations in this pathway, especially those affecting core signaling molecules such as PLCB4 and GNAI3, should be considered as potential candidates for other ear and jaw malformations. PMID: 22560091
    13. These results identify the Oa1 transducer Galphai3 as the first downstream component in the Oa1 signaling pathway. PMID: 21931697
    14. The mechanisms of regulation of GIRK by Galpha(i/o) using wild-type Galpha(i3) (Galpha(i3)WT) and Galpha(i3), were investigated. PMID: 21795707
    15. These results provide mechanistic insights into how reversible modulation of Galpha(i3) activity by AGS3 and GIV maintains the delicate equilibrium between promotion and inhibition of autophagy. PMID: 21209316
    16. Data suggest that Galphai-TNFAIP8-mediated rescue of pre-oncogenic cells enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation. PMID: 20607800
    17. we show that A3 adenosine receptor/Gi3 play important roles in human mast cells responses initiated on contact with activated T cells. PMID: 20190146
    18. These data present AGS3, G-proteins, and mInsc as candidate proteins involved in regulating cellular stress associated with protein-processing pathologies. PMID: 20065032
    19. Overexpression of GIPN stimulates proteasome-dependent reduction of endogenous G alpha i3 in HEK293 cells and reduces the half-life of overexpressed G alpha i3-YFP. PMID: 12826607
    20. diffraction data were collected to 2.5 A resolution at 100 K using synchrotron radiation at Pohang beamline 4A for human RGS10 complexed with Galphai3 [Galphai3] PMID: 16511171
    21. x-ray crystallography of the complex of RGS5 and Galphai(3) proteins with GDP/Mg(2+)/AlF(4)(-) at 3.0 A resolution PMID: 17100651
    22. The Galphai3-GIV switch serves to link direction sensing from different families of chemotactic receptors to formation of the leading edge during cell migration. PMID: 18663145
    23. Insulin-like growth factor-binding protein-5 stimulates growth of human intestinal muscle cells by activation of Galphai3. PMID: 19808657

    顯示更多

    收起更多

  • 相關疾病:
    Auriculocondylar syndrome 1 (ARCND1)
  • 亞細胞定位:
    Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    G-alpha family, G(i/o/t/z) subfamily
  • 數據庫鏈接:

    HGNC: 4387

    OMIM: 139370

    KEGG: hsa:2773

    STRING: 9606.ENSP00000358867

    UniGene: Hs.73799



主站蜘蛛池模板: 国产精品无码素人福利| 国产精品卡一卡2卡三卡网站| 国产精品久久久久久人妻| 欧美人与动另类xxxx| 国产一区二区| 在线亚洲欧美日韩精品专区| 色婷婷五月综合欧美图片| 亚洲人成77777在线播放网站不卡 国产 | 欧洲野花视频天堂视频p 亚洲aⅴ天堂av天堂无码 | 欧美乱大交av片久久123| 国内芒果精品自线一区2021| 国产精品调教视频一区| 啦啦啦www在线观看免费视频| 中文字幕一区二区人妻| 在线天堂新版最新版在线8 | 亚洲欧美日韩成人综合一区| 无码中字出轨中文人妻中文中| 色欲综合久久中文字幕网| 天天躁日日躁狠狠躁性色avq| 久久久久夜夜夜精品国产| 亲子乱av一区二区三区| 日99久9在线 | 免费| 黑人玩弄人妻中文在线| 艳妇乳肉豪妇荡乳av无码福利 | 极品粉嫩福利午夜在线播放| 2020久热爱精品视频在线观看| 丰满少妇被猛烈进入无码 | 香蕉在线依人视频| 欧美日韩在线亚洲综合国产人| 亚洲精品午夜无码专区| 久久久久精品无码一区二区三区| 再深点灬舒服灬太大了在线视频| 色婷婷综合缴情综免费观看| 男女啪祼交视频| 少妇饥渴偷公乱av在线观看涩爱| 久久天天躁狠狠躁夜夜躁app| 小说区 图片区色 综合区| 免费国产a国产片高清网站| 精品国内自产拍在线观看| 日韩精品一区二区三区色欲av | 欧美丰满熟妇xx猛交| 欧美色欧美亚洲另类二区|