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GMPR2 Antibody

  • 中文名稱：
    GMPR2兔多克隆抗體
  • 貨號：
    CSB-PA873740LA01HU
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GMPR2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GMPR2
  • 別名：
    GMPR2GMP reductase 2 antibody; GMPR 2 antibody; EC 1.7.1.7 antibody; Guanosine 5'-monophosphate oxidoreductase 2 antibody; Guanosine monophosphate reductase 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human GMP reductase 2 protein (1-366AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，GMPR2 Antibody (CSB-PA873740LA01HU)，的標記方式是Non-conjugated。對于GMPR2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA873740LB01HU GMPR2 Antibody, HRP conjugated ELISA
    FITC CSB-PA873740LC01HU GMPR2 Antibody, FITC conjugated
    Biotin CSB-PA873740LD01HU GMPR2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.
  • 基因功能參考文獻：
    1. Loss of expression of GMPR2 and PPARalpha is associated with breast cancer basal phenotype; indicating that they may play a role in carcinogenesis. PMID: 23208589
    2. A single crystal structure of human GMPR type 2 with IMP and NADPH fortuitously captures three different states, each of which mimics a distinct step in the catalytic cycle of guanosine monophosphate reductase(GMPR). PMID: 22037469
    3. Data suggest the existence of two distinct types of human GMP reductase molecular species, which can be used to explain the bimodal saturation curve noted with purified human erythrocyte GMP reductase. PMID: 12009299
    4. GMPR2 is a novel human GMP reductase, and overexpression of GMPR2 can promote the monocytic differentiation of HL-60 leukemia cells. PMID: 12669231
  • 蛋白家族：
    IMPDH/GMPR family, GuaC type 1 subfamily
  • 組織特異性：
    Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 4377

    OMIM: 610781

    KEGG: hsa:51292

    STRING: 9606.ENSP00000392859

    UniGene: Hs.368855



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