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  4. GMEB1 Antibody, FITC conjugated

GMEB1 Antibody, FITC conjugated

  • 中文名稱：
    GMEB1兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA896751LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GMEB1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GMEB1
  • 別名：
    DNA binding protein p96PIF antibody; DNA-binding protein p96PIF antibody; Glucocorticoid modulatory element binding protein 1 antibody; Glucocorticoid modulatory element-binding protein 1 antibody; GMEB 1 antibody; GMEB-1 antibody; Gmeb1 antibody; GMEB1_HUMAN antibody; P96PIF antibody; Parvovirus initiation factor p96 antibody; PIF 96 antibody; PIF p96 antibody; PIF96 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Glucocorticoid modulatory element-binding protein 1 protein (2-245AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
  • 基因功能參考文獻：
    1. consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters PMID: 11743720
    2. 1.55 A resolution crystal structure of a central portion of GMEB1, encompassing its SAND domain PMID: 12702733
    3. GMEB1 is capable of binding to the prodomain of caspase-2; findings indicated that GMEB1 might be an endogenous inhibitory protein that selectively interacts with prodomain of caspase-2 to disrupt the autoactivation PMID: 15555560
    4. GMEB1 is an endogenous regulator that selectively binds to initiator procaspases and inhibits caspase-induced apoptosis PMID: 16497673
    5. GMEB1 effectively attenuated caspase activation and apoptosis caused by these stresses in human neuroblastoma SK-N-MC cells, indicating that it functions as a potent inhibitor of caspase activation and apoptosis in response to oxidative stress. PMID: 18455874

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Note=May be also cytoplasmic.
  • 數據庫鏈接：

    HGNC: 4370

    OMIM: 604409

    KEGG: hsa:10691

    STRING: 9606.ENSP00000294409

    UniGene: Hs.632373



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