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  4. GLYAT Antibody

GLYAT Antibody

  • 中文名稱：
    GLYAT兔多克隆抗體
  • 貨號：
    CSB-PA009558GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    GLYAT
  • 別名：
    GLYAT antibody; ACGNAT antibody; CAT antibody; GATGlycine N-acyltransferase antibody; EC 2.3.1.13 antibody; Acyl-CoA:glycine N-acyltransferase antibody; AAc antibody; Aralkyl acyl-CoA N-acyltransferase antibody; Aralkyl acyl-CoA:amino acid N-acyltransferase antibody; Benzoyl-coenzyme A:glycine N-acyltransferase antibody; Glycine N-benzoyltransferase antibody; EC 2.3.1.71 antibody; HRP-1(CLP) antibody
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human GLYAT
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
  • 基因功能參考文獻：
    1. GLYAT exhibits mechanistic kinetic cooperativity towards its substrate glycine. PMID: 28759163
    2. Data indicate that Afrikaner caucasians have a Q61L single nucleotide polymorphism (SNP) occurring at a high frequency (12%). PMID: 26149650
    3. SNP variations causing amino acid substitutions in the human GLYAT gene influence the kinetic properties of the enzyme. PMID: 23237781
    4. We identify GLYAT gene which appears to co-regulate bone size phenotypes (BSPs) and appendicular lean mass (ALM). PMID: 23108985
    5. hGLYAT is a good candidate as a novel marker of hepatocellular carcinoma and may be a key molecule in the transition between differentiation and carcinogenesis of liver cells. PMID: 22475485
    6. The aim of this work was to report a comprehensive investigation of GLYAT genetic polymorphisms in DNA samples from 55 subjects of French Caucasian origin. PMID: 20925583

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  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Glycine N-acyltransferase family
  • 組織特異性：
    Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers.
  • 數據庫鏈接：

    HGNC: 13734

    OMIM: 607424

    KEGG: hsa:10249

    STRING: 9606.ENSP00000340200

    UniGene: Hs.145384



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