在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GLRB Antibody

  • 中文名稱:
    GLRB兔多克隆抗體
  • 貨號:
    CSB-PA088748
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from A549 cells and K562 cells, using GLRB antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GLRB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GLRB
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human GLRB.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents.
  • 基因功能參考文獻:
    1. GLRB variants are associated with etiopathogenesis of fear and anxiety disorders. PMID: 28872638
    2. A genome-wide significant association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293, P = 3.3 x 10 - 8; rs191260602, P = 3.9 x 10- 8).GLRB gene expression was found to be modulated by rs7688285 in brain tissue, as well as cell culture. PMID: 28167838
    3. Whole-exome sequencing in ASD patients from each family identified a second rare inherited genetic variant, affecting GLRB expressed in inhibitory or in excitatory synapses. PMID: 26055424
    4. We report novel GLRB mutations in hyperekplexia PMID: 23182654
    5. Systematic DNA sequencing of GLRB in individuals with hyperekplexia revealed new missense mutations in GLRB, resulting in M177R, L285R and W310C substitutions. PMID: 23238346
    6. This study describes the definitive assignment of GLRB as the third major gene for hyperekplexia and impacts on the genetic stratification and biological causation of this neonatal/paediatric disorder. PMID: 23184146
    7. Distinct properties of glycine receptor beta+/alpha- interface: unambiguously characterizing heteromeric interface reconstituted in homomeric protein. PMID: 22535951
    8. This study presents a large family with Hereditary hyperekplexia (HH) as a result of homozygous mutation in GLRB. PMID: 21391991
    9. The authors have identified a protein kinase C (PKC) phosphorylation site within the cytoplasmic domain of the beta-subunit of the GlyR (residue S403) that causes a reduction of the binding affinity between the receptor and gephyrin. PMID: 21829170
    10. Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation PMID: 14698963

    顯示更多

    收起更多

  • 相關疾病:
    Hyperekplexia 2 (HKPX2)
  • 亞細胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite. Cell membrane; Multi-pass membrane protein. Cytoplasm.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Glycine receptor (TC 1.A.9.3) subfamily, GLRB sub-subfamily
  • 數據庫鏈接:

    HGNC: 4329

    OMIM: 138492

    KEGG: hsa:2743

    STRING: 9606.ENSP00000264428

    UniGene: Hs.32973



主站蜘蛛池模板: 免费视频爱爱太爽了网站| 色欲麻豆国产福利精品| 国产艳妇av在线出轨| 奇米四色7777中文字幕| 国产一区丝袜高跟鞋| 人妻聚色窝窝人体www一区| 中文字幕日韩精品有码视频| 人妻久久久一区二区三区| 免费一本色道久久一区| 亚洲精品无码久久久久av老牛| av人摸人人人澡人人超碰手机版| 国产又色又爽又黄的免费| 真人作爱免费视频| 国产99久久久国产精品免费看| 九九热爱视频精品| 成年片色大黄全免费网站久久高潮| 久久久精品人妻一区二区三区蜜桃| www国产亚洲精品| 国产69精品久久久久乱码免费| 男人的天堂av社区在线| 国产精品高潮呻吟av久久男男| 五十路熟女一区二区三区 | 精品国产一区二区三区久久| 午夜寂寞少妇aaa片毛片| 97人洗澡从澡人人爽人人模| 亚洲午夜精品a片一区二区app| 日韩成人大屁股内射喷水| 国内精品久久久久久中文字幕| 日韩精品av一区二区三区 | 国产百合互慰吃奶互揉视频| 中文字幕无码免费久久99| 好爽别插了无码视频| 2021精品国夜夜天天拍拍| 中文字幕亚洲男人的天堂网络| 久久国内精品自在自线400部 | 掀开奶罩边吃边摸下娇喘视频| 国产爽视频在线观看视频| 免费看又黄又无码的网站| 久久久久爽爽爽爽一区老女人| 成在人线av无码免费高潮喷水| 在线亚洲精品国产成人av剧情|