在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GLE1 Antibody

  • 中文名稱:
    GLE1兔多克隆抗體
  • 貨號(hào):
    CSB-PA700651EA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunoprecipitating GLE1 in A549 whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-PA700651EA01HU in A549 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA700651EA01HU (6µg) + A549 whole cell lysate (500µg)
      Lane 3: A549 whole cell lysate (20µg)
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate
      All lanes: GLE1 antibody at 2.8µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 80, 76 kDa
      Observed band size: 80 kDa
    • Immunocytochemistry analysis of human melanoma using CSB-PA700651EA01HU at dilution of 1:100
    • Immunocytochemistry analysis of human breast cancer using CSB-PA700651EA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA700651EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GLE1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GLE1
  • 別名:
    GLE 1 antibody; GLE1 antibody; GLE1 like protein antibody; GLE1 like RNA export mediator antibody; GLE1 RNA export mediator homolog antibody; GLE1 RNA export mediator like (yeast) antibody; GLE1-like protein antibody; GLE1_HUMAN antibody; GLE1L antibody; hGLE1 antibody; LCCS 1 antibody; LCCS antibody; LCCS1 antibody; Nucleoporin GLE1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Nucleoporin GLE1 protein (141-380AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,GLE1 Antibody (CSB-PA700651EA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于GLE1 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA700651EB01HU GLE1 Antibody, HRP conjugated ELISA
    FITC CSB-PA700651EC01HU GLE1 Antibody, FITC conjugated
    Biotin CSB-PA700651ED01HU GLE1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC, IF, IP
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
    IP 1:200-1:2000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
  • 基因功能參考文獻(xiàn):
    1. Pathogenic variants in the GLE1 gene are rare in Chinese ALS patients. PMID: 29398120
    2. Data indicate 2 siblings with a homozygous p.I684T mutation in RNA export mediator (GLE1). PMID: 28657126
    3. These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism. PMID: 29746542
    4. We identified bi-allelic mutations in GLE1 in two unrelated individuals with motor delays, feeding difficulties, and respiratory insufficiency who survived beyond the perinatal period. Each affected child had missense variants predicted to result in amino acid substitutions near the C-terminus of GLE1 that are predicted to disrupt protein-protein interaction or GLE1 protein targeting. PMID: 28884921
    5. It was concluded that the amyotrophic lateral sclerosis-linked Gle1-c.1965-2A>C mutation generates a protein isoform capable of both Gle1A- and Gle1B-ascribed functions, and thereby uncoupled from normal mechanisms of Gle1 regulation. PMID: 26776475
    6. We also suggest that lethal congenital contracture syndrome 1 (LCCS1) and lethal arthrogryposis with anterior horn disease (LAAHD), the two AMC subtypes related to GLE1, do not have sufficient clinical or molecular differentiation to be considered allelic disorders. Rather, GLE1 mutations cause a variable spectrum of AMC severity including a non-lethal variant described herein PMID: 27684565
    7. Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6. PMID: 26655997
    8. Role for Gle1A during stress granule formation and translation regulation during environmental stress responses is examined. PMID: 25694449
    9. We report the identification of the first heterozygous mutations in GLE1 ever found to be associated with amyotrophic lateral sclerosis. PMID: 25343993
    10. Lethal congenital contracture syndrome 1 and lethal arthrogryposis with anterior horn cell disease are associated with defective Gle1 function during the export of mRNA. [review] PMID: 24275432
    11. Report documents a requirement for Gle1 self-association during mRNA export and uncover molecular defects underlying a lethal human disease lethal congenital contracture syndrome-1. PMID: 24243016
    12. Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export. PMID: 22064466
    13. defective zebrafish GLE1 function in human LCCS1 results in both neurogenic and non-neurogenic defects linked to the apoptosis of proliferative organ precursors PMID: 22357925
    14. The unique carboxyl-terminal 43 amino acid region of the hGle1B isoform mediates binding to the C-terminal non-phenylalanine- glycine region of the nucleoporin hCG1/NPL1. PMID: 16000379
    15. Mutations in mRNA export mediator GLE1 result in fetal motoneuron disease. PMID: 18204449

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Lethal congenital contracture syndrome 1 (LCCS1); Lethal arthrogryposis with anterior horn cell disease (LAAHD)
  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm.; [Isoform 1]: Cytoplasm. Nucleus, nuclear pore complex.
  • 蛋白家族:
    GLE1 family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4315

    OMIM: 253310

    KEGG: hsa:2733

    STRING: 9606.ENSP00000308622

    UniGene: Hs.522418



主站蜘蛛池模板: 国产精品国产三级国产普通话| 国产色无码精品视频免费 | 国产成人精品日本亚洲第一区| 天堂资源中文网| 最新国产aⅴ精品无码| 亚洲中文无码mv| 国产成人无码一二三区视频| 欧美午夜精品一区二区三区电影| 国产亚洲中文日本不卡二区| 日韩 高清 无码 人妻| 无码办公室丝袜ol中文字幕| 欧美日韩国产精品自在自线| 亚洲一线二线三线写真| 国产精品高潮呻吟av久久小说| 国产精品自在拍首页视频| 国产 亚洲 制服 无码 中文 | 久久久亚洲精华液精华液精华液| 一本大道久久东京热av| 久久99精品国产免费观观| 无码h肉动漫在线观看| 国产xxxx做受性欧美88| 亚洲国产精品成人综合色| 双乳奶水饱满少妇呻吟| 国产极品美女高潮无套在线观看| 无码h肉在线观看免费一区| 成人网站精品久久久久| 国产a∨精品一区二区三区不卡| 国产成人精品男人的天堂| 男人边吻奶边挵进去视频| 久久精品日韩av无码| 蜜臀久久99精品久久久久久| 在线观看一区二区三区国产免费| 日本熟妇厨房xxxxx乱| 少妇高潮喷水久久久久久久久久| 欧美不卡高清一区二区三区| 亚洲一区日韩高清中文字幕亚洲| 大伊香蕉精品视频在线直播| 欧美成人片在线观看| 性xxxxx大片免费视频| 欧美大胆作爱视频欣赏人体| 18禁超污无遮挡无码免费游戏|