在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GLCE Antibody

  • 中文名稱:
    GLCE兔多克隆抗體
  • 貨號:
    CSB-PA009492LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: GLCE antibody at 12µg/ml
      Lane 1: Rat liver tissue
      Lane 2: Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 71 kDa
      Observed band size: 71 kDa
    • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA009492LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA009492LA01HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GLCE Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GLCE
  • 別名:
    GLCE antibody; KIAA0836 antibody; D-glucuronyl C5-epimerase antibody; EC 5.1.3.17 antibody; Heparan sulfate C5-epimerase antibody; Hsepi antibody; Heparin/heparan sulfate:glucuronic acid C5-epimerase antibody; Heparosan-N-sulfate-glucuronate 5-epimerase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human D-glucuronyl C5-epimerase protein (29-617AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,GLCE Antibody (CSB-PA009492LA01HU),的標記方式是Non-conjugated。對于GLCE Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA009492LB01HU GLCE Antibody, HRP conjugated ELISA
    FITC CSB-PA009492LC01HU GLCE Antibody, FITC conjugated
    Biotin CSB-PA009492LD01HU GLCE Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.
  • 基因功能參考文獻:
    1. Results show that overexpression of Hsepi alone resulted in an unexpected increase in heparan sulfate (HS) chain length. A Hsepi point-mutant (Y168A), devoid of catalytic activity, failed to affect chain length. Moreover, the effect of Hsepi overexpression on HS chain length was abolished by simultaneous overexpression of 2OST. PMID: 27511124
    2. The obtained data suggest an involvement of GLCE rs3865014 in breast cancer development. Heterozygous AG genotype might be a risk factor for breast cancer susceptibility in Siberian women and is associated with aggressive ER-negative and triple-negative cancer subtypes. PMID: 28734894
    3. The GLCE gene polymorphism rs3865014 appears to have biological relevance in human pathophysiology. PMID: 27699767
    4. C5-epimerase and 2-O-sulfotransferase in association generate extended domains of consecutive GlcNS-IdoA2S Sequence. PMID: 25594747
    5. GLCE may be used as a potential model to study the functional role of intratumor cell heterogeneity in prostate cancer progression. PMID: 24403231
    6. activation of angiogenesis as a main molecular mechanism of pro-oncogenic effect of GLCE in prostate cancer. PMID: 24264315
    7. positive correlation between miRNA-218 and GLCE mRNA, and negative correlation between miRNA-218 and GLCE protein levels in breast tissues and primary tumors in vivo, supporting a direct involvement of miRNA-218 in posttranscriptional regulation of GLCE PMID: 22968430
    8. Chondroitin-glucuronate C5-epimerase is a potential candidate for tumour antigen with immunogenicity and the peptides derived from this antigen could be useful in hepatocellular carcinoma immunotherapy. PMID: 22830596
    9. A correlation was observed between D-glucuronyl C5-epimerase (GLCE), TCF4 and beta-catenin expression in breast cancer cells and primary tumors, suggesting an important role for TCF4/beta-catenin in regulating GLCE expression both in vitro and in vivo. PMID: 22805760
    10. The biphasic mode of C(5)-epi offers a novel mechanism to regulate the biosynthesis of HS with the desired biological functions. PMID: 22528493
    11. Loss of D-glucuronyl C-5 epimerase is associated with small-cell lung cancer. PMID: 21654676
    12. SNPs in GLCE are associated with triglyceride and HDL-C levels in Turks, and mouse studies support a role for glce in lipid metabolism. PMID: 21488854
    13. The regulation of GLCE expression by 2 cis-acting elements of the beta-catenin-TCF4 complex located in the enhancer region of the promoter are reported. PMID: 15853773
    14. in 82-84% of human breast tumors there is either downregulation or loss of D-glucuronyl C5-epimerase mRNA expression and significant decrease of the protein content PMID: 17985344

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    D-glucuronyl C5-epimerase family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17855

    OMIM: 612134

    KEGG: hsa:26035

    STRING: 9606.ENSP00000261858

    UniGene: Hs.183006



主站蜘蛛池模板: 亚洲国产精品无码久久98| 久久人人爽人人爽人人片ⅴ | 国产一卡二卡四卡无卡免费| 精品无码国产污污污免费| 无码中文字幕日韩专区视频| 男女啪啪做爰高潮免费网站| 日本中文一二区有码在线 | 国产精品国产三级国产剧情| 国产中的精品av一区二区 | 五月色婷婷丁香无码三级| 综合自拍亚洲综合图区高清| 欧美人与动牲交aⅴ| 老太婆性杂交欧美肥老太| 欧美成人秋霞久久aa片| 国产无遮挡又黄又爽在线视频| 亚洲欧洲精品无码av| 国产精品9999久久久久| 亚洲性久久久影院| 欧洲熟妇性色黄| 亚洲精品国产综合麻豆久久99| 亚洲欧美v国产一区二区| 国产成人高清精品亚洲| 轻点好疼好大好爽视频| 天堂а√在线中文在线新版| 久久精品国产亚洲夜色av网站| 动漫av纯肉无码免费播放| 宝贝腿开大点我添添公视频免费| 精品久久久久久无码人妻热| 日本丰满少妇高潮呻吟| 老司机性色福利精品视频| 国产成人不卡无码免费视频| 18禁高潮出水呻吟娇喘蜜芽| 女人18毛片水最多| 亚洲精品久久片久久久久| 高潮潮喷奶水飞溅视频无码| 国产成人无码一区二区三区| 精品人妻码一区二区三区| 久久精品无码免费不卡 | 九一九色国产| 午夜福利理论片高清在线| 乌克兰美女浓毛bbw|