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GK Antibody

  • 中文名稱：
    GK兔多克隆抗體
  • 貨號：
    CSB-PA115735
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/60.
    • Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/60.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein corresponding to a region derived from internal residues of Human glycerol kinase
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Key enzyme in the regulation of glycerol uptake and metabolism.
  • 基因功能參考文獻(xiàn)：
    1. Both patients were found to have Xp21.2 deletions involving all coding seqeunces of the glycerol kinase (GK) gene. PMID: 27087023
    2. Two siblings with the contiguous X-linked gene deletion syndrome, complex glycerol kinase deficiency, are described. The elder sibling demonstrates the difficulties diagnosing this rare condition. PMID: 20110216
    3. missense mutations and deletions in glycerol kinase is associated with persistent hypertriglyceridemia PMID: 12636049
    4. a functional HNF-4alpha binding site in the first 500 bp of the 5(') upstream region is important for increased levels of glycerol kinase expression PMID: 14654354
    5. Comparison of expression patterns, as well as enzymatic characteristics and subcellular localization of alternatively spliced glycerol kinase isoforms. PMID: 15845384
    6. Results suggest that influences on RNA processing and protein stability represent modifiers of the glycerol kinase deficiency phenotype. PMID: 16549535

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  • 相關(guān)疾病：
    Glycerol kinase deficiency (GKD)
  • 亞細(xì)胞定位：
    Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.
  • 蛋白家族：
    FGGY kinase family
  • 組織特異性：
    Highly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4289

    OMIM: 300474

    KEGG: hsa:2710

    UniGene: Hs.1466



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