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  4. GINS4 Antibody, Biotin conjugated

GINS4 Antibody, Biotin conjugated

  • 中文名稱：
    GINS4兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA871563LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GINS4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GINS4
  • 別名：
    DNA replication complex GINS protein SLD5 antibody; GINS complex subunit 4 (Sld5 homolog) antibody; GINS complex subunit 4 antibody; GINS4 antibody; SLD5 antibody; SLD5 homolog antibody; SLD5 S cerevisiae homolog of antibody; SLD5_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DNA replication complex GINS protein SLD5 protein (2-223AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.
  • 基因功能參考文獻：
    1. Knockdown of SLD5 using small interfering RNA resulted in reduction of cell growth both in vitro and an in vivo xenograft model. Moreover, we found that high levels of SLD5 in bladder cancer cells result from downregulation of microRNA (miR)-370 that otherwise suppresses its expression. PMID: 27499248
    2. Sld5 a component of GINS complex interacts with SIK1 and recruits it to the sites of DNA replication at the onset of S phase. PMID: 27592030
    3. The C-terminal domains of the Sld5 and Psf1 subunits are connected by linker regions to the core complex, and the C-terminal domain of Sld5 is important for core complex assembly. PMID: 17417653
  • 亞細胞定位：
    Nucleus. Chromosome. Cytoplasm.
  • 蛋白家族：
    GINS4/SLD5 family
  • 數據庫鏈接：

    HGNC: 28226

    OMIM: 610611

    KEGG: hsa:84296

    STRING: 9606.ENSP00000276533

    UniGene: Hs.656996



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