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  4. GGPS1 Antibody

GGPS1 Antibody

  • 中文名稱：
    GGPS1兔多克隆抗體
  • 貨號：
    CSB-PA009393HA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA009393HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA009393HA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GGPS1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GGPS1
  • 別名：
    (2E antibody; 6E)-farnesyl diphosphate synthase antibody; Dimethylallyltranstransferase antibody; Farnesyl diphosphate synthase antibody; Farnesyltranstransferase antibody; Geranylgeranyl diphosphate synthase 1 antibody; Geranylgeranyl diphosphate synthase antibody; Geranylgeranyl pyrophosphate synthase antibody; Geranylgeranyl pyrophosphate synthetase antibody; Geranyltranstransferase antibody; GGPP synthase antibody; GGPP synthetase antibody; GGPPS antibody; GGPPS_HUMAN antibody; GGPPS1 antibody; GGPPSase antibody; GGPS1 antibody; OTTHUMP00000036073 antibody; OTTHUMP00000216161 antibody; OTTHUMP00000216163 antibody; OTTHUMP00000216164 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Geranylgeranyl pyrophosphate synthase protein (1-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，GGPS1 Antibody (CSB-PA009393HA01HU)，的標記方式是Non-conjugated。對于GGPS1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA009393HB01HU GGPS1 Antibody, HRP conjugated ELISA
    FITC CSB-PA009393HC01HU GGPS1 Antibody, FITC conjugated
    Biotin CSB-PA009393HD01HU GGPS1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
  • 基因功能參考文獻：
    1. results may support a model in which accumulation of susceptibility variants (including some in relevant genes, notably GGPS1) may lead to a possible genetic component of predisposition to atypical femoral fractures. PMID: 28467865
    2. GGPPS1 may play a critical role during the development of HCC from cirrhosis and is of clinical significance for predicting biological character of HCC. PMID: 24716791
    3. Egr-1 most likely does not induce the constitutive activation of Erk1/2 through its target gene GGPS1. PMID: 23478574
    4. the Egr-1/GGPPS/Erk1/2 pathway is responsible for insulin resistance during hyperinsulinism PMID: 21321112
    5. these results reveal a new EGR-1/GGPPS/MAPK signaling pathway that controls cigarette smoke-induced pulmonary inflammation. PMID: 21224049
    6. Study suggested that GGPS1 -8188A ins/del polymorphism may confer susceptibility to femoral neck BMD response to bisphosphonate therapy in Korean women. PMID: 20191015
    7. crystal structure; it reveals that three dimers join together to form a propeller-bladed hexameric molecule with a mass of approximately 200 kDa PMID: 16698791
    8. Farnesyltranstransferase mutations are associated with lonafarnib resistance PMID: 17536018
    9. results indicate that the active form of GGPS in the solution is an octamer rather than hexamer or dimer PMID: 17646172
    10. Evidence for a non-membrane bound isoform of geranylgeranyl diphosphate synthase 1 in rat. PMID: 8419360

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    FPP/GGPP synthase family
  • 組織特異性：
    Abundantly expressed in testis. Found in other tissues to a lower extent.
  • 數據庫鏈接：

    HGNC: 4249

    OMIM: 606982

    KEGG: hsa:9453

    STRING: 9606.ENSP00000282841

    UniGene: Hs.730768



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