在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GGA2 Antibody

  • 中文名稱:
    GGA2兔多克隆抗體
  • 貨號:
    CSB-PA009385GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    GGA2
  • 別名:
    1200007E24Rik antibody; ADP ribosylation factor binding protein 2 antibody; ADP ribosylation factor binding protein GGA 2 antibody; ADP ribosylation factor binding protein GGA2 antibody; ADP-ribosylation factor-binding protein GGA2 antibody; ARF-binding protein 2 antibody; FLJ20966 antibody; Gamma adaptin related protein 2 antibody; gamma ear-containing antibody; Gamma-adaptin-related protein 2 antibody; GGA 2 antibody; Gga2 antibody; GGA2_HUMAN antibody; Golgi associated gamma adaptin ear containing ARF binding protein 2 antibody; Golgi localized gamma ear containing ARF binding protein 2 antibody; Golgi-localized antibody; KIAA1080 antibody; Vear antibody; VHS domain and ear domain containing protein antibody; VHS domain and ear domain of gamma adaptin antibody; VHS domain and ear domain of gamma-adaptin antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human GGA2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network.
  • 基因功能參考文獻:
    1. Study shows that reduced expression of GGA3 resultes in accumulation of endocytosed EGFR within enlarged endosomes. GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth. Finally, GGA2 was upregulated in 30.8% of human hepatocellular carcinomas and 23.3% of colorectal cancers. PMID: 29358589
    2. PI4KIIIbeta interaction with the VHS domain of GGA2 affected PI4KIIIbeta localization. PMID: 28289207
    3. full length alpha2B-AR associated with GGA2 but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop. PMID: 27901063
    4. These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane. PMID: 24407285
    5. GGA2 mediates a vital function that cannot be compensated for by GGA1and/or GGA3. PMID: 22291915
    6. endocytosis and intracellular transport of memapsin 2, mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2 PMID: 12135764
    7. GGA proteins function with the phosphorylated ACDL in the memasin 2-recycling pathway from endosomes to trans Golgi on the way back to the cell surface. PMID: 15615712
    8. Results demonstrate that cargo proteins contribute to the recruitment of GGA2 onto membranes and to the formation of GGA-positive clathrin-coated vesicles. PMID: 17451558
    9. These results show that the dual roles of PI4P can promote specific GGA targeting and cargo recognition at the trans-Golgi network. PMID: 17494868
    10. p56 tightly cooperates with the GGAs in the sorting of cathepsin D to lysosomes, probably by enabling the movement of GGA-containing transport carriers. PMID: 17596511
    11. GGA2 is recruited to the trans-Golgi network independently of the other Golgi-localized, gamma-ear-containing, ARF-binding proteins and is required for the efficient sorting of lysosomal enzymes PMID: 18431031
    12. GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs. PMID: 19788741

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein.
  • 蛋白家族:
    GGA protein family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 16064

    OMIM: 606005

    KEGG: hsa:23062

    STRING: 9606.ENSP00000311962

    UniGene: Hs.460336



主站蜘蛛池模板: 日韩亚洲欧美精品综合| 水蜜桃精品一二三| 国产亚洲精品久久久ai换脸| 一二三四在线观看视频韩国| 99久热在线精品视频观看| 麻豆av传媒蜜桃天美传媒| 国产99视频精品免费视频76| av中文无码韩国亚洲色偷偷| 午夜精品一区二区三区免费视频 | 狠狠亚洲色一日本高清色| 亚洲欧洲日本精品专线| 午夜家庭影院| 天天躁夜夜踩很很踩2022| 狠狠色丁香五月综合缴情婷婷五月| 少妇高潮喷水惨叫久久久久电影| 中文区中文字幕免费看| 在线欧美日韩制服国产| 亚洲а∨天堂久久精品| 国产狂喷潮在线观看| 夜爽8888视频在线观看| 无码高潮又爽又黄a片日本动漫| 亚洲国产欧美中文丝袜日韩| 国产免费无码一区二区三区| 日本在线看片免费人成视频1000| 免费的av网站在线观看国产精品 | 欧美成人精品三级网站视频| 国产乱妇无码大片在线观看 | av无码一区二区三区| 国产无遮挡裸体免费视频| 欧美乱妇xxxxxbbbbb| 欧美性潮喷xxxxx免费视频看| 日本最新免费二区三区| 肉感饱满中年熟妇日本| 国产成年无码久久久免费| 成年美女黄网站色奶头大全| 国产午夜鲁丝无码拍拍| 午夜嘿嘿嘿在线观看| 国产极品粉嫩泬免费观看| 女人色极品影院| 日本一上一下爱爱免费| 国产精品免费大片|