在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GGA2 Antibody

  • 中文名稱:
    GGA2兔多克隆抗體
  • 貨號:
    CSB-PA009385GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    GGA2
  • 別名:
    1200007E24Rik antibody; ADP ribosylation factor binding protein 2 antibody; ADP ribosylation factor binding protein GGA 2 antibody; ADP ribosylation factor binding protein GGA2 antibody; ADP-ribosylation factor-binding protein GGA2 antibody; ARF-binding protein 2 antibody; FLJ20966 antibody; Gamma adaptin related protein 2 antibody; gamma ear-containing antibody; Gamma-adaptin-related protein 2 antibody; GGA 2 antibody; Gga2 antibody; GGA2_HUMAN antibody; Golgi associated gamma adaptin ear containing ARF binding protein 2 antibody; Golgi localized gamma ear containing ARF binding protein 2 antibody; Golgi-localized antibody; KIAA1080 antibody; Vear antibody; VHS domain and ear domain containing protein antibody; VHS domain and ear domain of gamma adaptin antibody; VHS domain and ear domain of gamma-adaptin antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human GGA2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network.
  • 基因功能參考文獻:
    1. Study shows that reduced expression of GGA3 resultes in accumulation of endocytosed EGFR within enlarged endosomes. GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth. Finally, GGA2 was upregulated in 30.8% of human hepatocellular carcinomas and 23.3% of colorectal cancers. PMID: 29358589
    2. PI4KIIIbeta interaction with the VHS domain of GGA2 affected PI4KIIIbeta localization. PMID: 28289207
    3. full length alpha2B-AR associated with GGA2 but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop. PMID: 27901063
    4. These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane. PMID: 24407285
    5. GGA2 mediates a vital function that cannot be compensated for by GGA1and/or GGA3. PMID: 22291915
    6. endocytosis and intracellular transport of memapsin 2, mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2 PMID: 12135764
    7. GGA proteins function with the phosphorylated ACDL in the memasin 2-recycling pathway from endosomes to trans Golgi on the way back to the cell surface. PMID: 15615712
    8. Results demonstrate that cargo proteins contribute to the recruitment of GGA2 onto membranes and to the formation of GGA-positive clathrin-coated vesicles. PMID: 17451558
    9. These results show that the dual roles of PI4P can promote specific GGA targeting and cargo recognition at the trans-Golgi network. PMID: 17494868
    10. p56 tightly cooperates with the GGAs in the sorting of cathepsin D to lysosomes, probably by enabling the movement of GGA-containing transport carriers. PMID: 17596511
    11. GGA2 is recruited to the trans-Golgi network independently of the other Golgi-localized, gamma-ear-containing, ARF-binding proteins and is required for the efficient sorting of lysosomal enzymes PMID: 18431031
    12. GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs. PMID: 19788741

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein.
  • 蛋白家族:
    GGA protein family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 16064

    OMIM: 606005

    KEGG: hsa:23062

    STRING: 9606.ENSP00000311962

    UniGene: Hs.460336



主站蜘蛛池模板: 国产中文字幕乱人伦在线观看| 国产69精品久久久久孕妇| 国产男女免费完整视频网页| 欧美人与物videos另类| 人妻少妇一区二区三区| 在线精品视频一区二区| 欧美人与禽z0zo牲伦交| 东京热久久综合久久88| 久久久久人妻精品一区二区三区| 性夜影院午夜看片| 青青草在在观免费福利线观看| 综合久久给合久久狠狠狠97色| 亚洲乱码中文字幕在线| 夜夜精品无码一区二区三区| 综合色一色综合久久网| 美女大量吞精在线观看456| 欧美变态另类牲交zozo| 成人美女黄网站色大色费全看| 伊人久久综合无码成人网| 国产亚洲精品精品精品| 乱码人妻一区二区三区| 十八禁午夜福利免费网站| 亚洲男人的天堂在线aⅴ视频| 大地资源中文第三页 | 亚洲国产精品18久久久久久 | 上司的丰满人妻中文字幕| 狠狠色丁香婷婷综合潮喷| 新普新京亚洲欧美日韩国产 | 久久综合伊人77777| 国产熟妇午夜精品aaa| 精品国产午夜福利在线观看| 久久久久成人精品| 欧美乱码精品一区二区三区| 国产精品美脚玉足脚交| 国产成人精品免费午夜app| 久久人妻少妇嫩草av无码专区| 亚洲精品无码mⅴ在线观看| 国产亚洲日韩妖曝欧美| 亚洲加勒比无码一区二区| 国产精品青青在线观看爽香蕉| 国产高清精品软件丝瓜软件|