在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GGA1 Antibody, Biotin conjugated

  • 中文名稱:
    GGA1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA890911LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GGA1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GGA1
  • 別名:
    4930406E12Rik antibody; ADP ribosylation factor binding protein 1 antibody; ADP ribosylation factor binding protein GGA1 antibody; ADP-ribosylation factor-binding protein GGA1 antibody; ARF binding protein 1 antibody; ARF-binding protein 1 antibody; Gamma adaptin related protein 1 antibody; gamma ear-containing antibody; Gamma-adaptin-related protein 1 antibody; GGA 1 antibody; GGA1 antibody; GGA1 protein antibody; GGA1_HUMAN antibody; Golgi associated gamma adaptin ear containing ARF antibody; Golgi associated gamma adaptin ear containing ARF binding protein 1 antibody; Golgi localized gamma ear containing ARF binding protein 1 antibody; Golgi-localized antibody; OTTHUMP00000028975 antibody; OTTHUMP00000042200 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human ADP-ribosylation factor-binding protein GGA1 protein (1-89AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane. Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network.
  • 基因功能參考文獻:
    1. These findings show that the AD-like phenotype of NPC model cells can be partly reverted by promoting a non-amyloidogenic processing of APP through the upregulation of GGA1 supporting its preventive role against AD PMID: 24866237
    2. On basis of these results, propose that GGA1 facilitates LR11 endocytic traffic and that LR11 modulates A-beta levels by promoting amyloid-beta precursor protein traffic to the endocytic recycling compartment PMID: 22621900
    3. X-ray structure of the GGA1 VHS domain alone, and in complex with the carboxy-terminal peptide of cation-independent mannose 6-phosphate receptor containing an ACLL sequence PMID: 11859376
    4. The 2.4-A crystal structure of the GAT domain of human GGA1 reveals a three-helix bundle, with a long N-terminal helical extension that is not conserved in GAT domains that do not bind ARF. PMID: 12668765
    5. X-ray crystal structures of the human GGA1-GAT domain and the complex between ARF1-GTP and the N-terminal region of the GAT domain PMID: 12679809
    6. Crystal structure of the human GGA1 GAT domain PMID: 12767220
    7. A hydrophobic surface patch on the C-terminal three-helix bundle motif of the GGA1 GAT domain is directly involved in binding with a coiled-coil region of rabaptin-5. PMID: 14636058
    8. GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region PMID: 14973137
    9. Rabaptin-5, ubiquitin, and TSG101 bind to overlapping but distinct binding sites on the trihelical bundle subdomain of GGA-1 protein PMID: 15143060
    10. Our data indicate that GGA proteins are not only involved in the sorting at the TGN but also mediate the retrograde transport of cargo proteins from endosomes to the TGN. PMID: 15886016
    11. the trafficking of adiponectin through its secretory pathway is dependent on GGA-coated vesicles PMID: 16407204
    12. GGA1 prevented APP beta-cleavage products from becoming substrates for gamma-secretase. Direct binding of GGA1 to BACE was not required for these effects, but the integrity of the GAT (GGA1 and TOM) domain of GGA1 was. PMID: 17005855
    13. GGA1 alters the proteolytic processing of beta-amyloid precursor protein (APP) and the secretion of APPs and amyloid-beta, suggesting a role of GGA1 in Alzheimer's disease pathogenesis. PMID: 17151287
    14. the interaction between the hinge region and the GAE domain underlies the autoregulation of GGA function in clathrin-mediated trafficking through competing with the accessory proteins and the AP-1 complex PMID: 17506864

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein.
  • 蛋白家族:
    GGA protein family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 17842

    OMIM: 606004

    KEGG: hsa:26088

    STRING: 9606.ENSP00000341344

    UniGene: Hs.499158



主站蜘蛛池模板: 亚洲性无码av在线| 天码av无码一区二区三区四区| 免费观看又色又爽又黄的崩锅| 中文精品一卡2卡3卡4卡国色| 亚洲日本va中文字幕人妖| 天堂а√8在线最新版在线| 亚洲第一av网站| 久久久久99精品成人片牛牛影视 | 无码中文字幕波多野结衣| 国产jk白丝在线观看免费| 国产在线精品一区二区三区不卡| 少妇与黑人一二三区无码| 狠狠久久精品中文字幕无码| 国产精品亚洲а∨天堂123| 精产国品一二三产区m553麻豆| 久久人人爽人人爽人人片av| 欧美乱妇xxxxxbbbbb| 人妻熟妇乱又伦精品视频| 欧美 日韩 人妻 高清 中文| 小宝贝荡货啊用力水湿aⅴ视频 | 在线观看免费视频污网站| 让少妇高潮无乱码高清在线观看| 夜夜高潮夜夜爽夜夜爱爱一区| 色播久久人人爽人人爽人人片av| 后进式无遮挡啪啪摇乳动态图| 亚洲精品综合欧美一区二区三区| 超碰免费公开| 50岁退休熟女露脸高潮| 日韩精品真人荷官无码| 久久久综合九色合综| 可以直接看的无码av| 国产精品高清不卡在线播放| 午夜国产亚洲精品一区| 99久热re在线精品99 6热视频| 久久人妻无码中文字幕| 欧美日韩人妻精品一区二区在线 | 成熟丰满熟妇高潮xxxxx| 色悠久久久久综合欧美99| 欧美黑人巨大videos极品| 国产婷婷色一区二区三区| 最近中文2019字幕第二页|