在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GFRA1 Antibody

  • 中文名稱:
    GFRA1兔多克隆抗體
  • 貨號:
    CSB-PA008804
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    GDNF family receptor alpha 1 antibody; GDNF family receptor alpha-1 antibody; GDNF R antibody; GDNF RA antibody; GDNF receptor alpha antibody; GDNF receptor alpha-1 antibody; GDNFR alpha 1 antibody; GDNFR alpha antibody; GDNFR antibody; GDNFR-alpha-1 antibody; GDNFRA antibody; GDNFRalpha antibody; GFR alpha 1 antibody; GFR alpha1 antibody; GFR-alpha-1 antibody; GFRA 1 antibody; Gfra1 antibody; GFRA1_HUMAN antibody; GFRalpha1 antibody; Glial cell line derived neurotrophic factor receptor alpha antibody; GPI linked anchor protein antibody; MGC23045 antibody; PI linked cell surface accessory protein antibody; RET 1L antibody; RET ligand 1 antibody; RET1L antibody; RETL 1 antibody; RETL1 antibody; TGF beta related neurotrophic factor receptor 1 antibody; TGF-beta-related neurotrophic factor receptor 1 antibody; TRNR 1 antibody; TRNR1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human GFRα-1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
  • 基因功能參考文獻:
    1. circGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC. PMID: 29037220
    2. the methylation status of CpG sites in GFRA1 and GSTM2 may have a role and could be used as potential biomarkers for the screening of rectal cancer PMID: 27566576
    3. GFRA1 regulates AMPK-dependent autophagy by promoting SRC phosphorylation independent of proto-oncogene RET kinase PMID: 27754745
    4. that the consequences of this is that GFRalpha-1-mediated signalling is altered during the ageing process PMID: 27346872
    5. RET c.1296A may be a common susceptibility allele for nephron underdosing-related diseases. The 5'-UTR and intronic variants near exon 5 of GFRA1 are not associated with nephron endowment. PMID: 27533506
    6. Hox proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes. PMID: 26904955
    7. This study demonstrate, using a knock-in mouse model in which GFRalpha1 is no longer located in lipid rafts, that the developmental functions of GDNF in the periphery require the translocation of the GDNF receptor complex into lipid rafts. PMID: 26400951
    8. Methylation changes of GFRA1, SRF, and ZNF382 may be a potential biomarker set for prediction of gastric carcinoma metastasis. PMID: 25009298
    9. GFRalpha1 levels in neurons from autopsied AD brains are significantly decreased. PMID: 25253858
    10. In the cochlea, GFRalpha-1 was identified mainly in the cell bodies of the spiral neurons. In the organ of Corti, GFRalpha-1 was demonstrated in the Deiters' cells, Hensen cells, inner pillar cells, and weakly in inner hair cells but not in the outer hair cells. PMID: 24139947
    11. The study shows co-localization of RET with GFRA1 and GFRA2 in myenteric ganglia of the adult human colon. PMID: 23881409
    12. The expression of GFRalpha1 and/or GFRalpha3, especially when combined with ARTN expression, may be useful predictors of disease progression and outcome in specific subtypes of mammary carcinoma. PMID: 23351331
    13. Mutations in GFRA1 gene is associated with urinary tract malformations. PMID: 22729463
    14. Post-synaptic transgenic GFRalpha1 has profound effects on the development of dopamine neurons, resulting in a 40% increase in the adult number. PMID: 21133924
    15. This study found nominally-significant evidence for interactions between GFRA1, 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia. PMID: 20116071
    16. Results identify persephin, a GDNF family member, as a novel ligand for GFRalpha1/RET receptor complex. PMID: 20350599
    17. MEN2 arises from activating missense mutations in RET, causing autodimerization under certain conditions. The position of missense mutations influences medullary thyroid carcinoma aggressiveness. Review. PMID: 20669561
    18. Here we report that human nigral dopaminergic neurons express GFRalpha1 and RET receptors at all ages. There was no reduction in the number of neurons expressing these receptors as a function of age. PMID: 20347960
    19. GFR-alpha1 mRNA transcripts were detected in oocytes and GCs from all samples from fetuses, girls and adult women. PMID: 19896648
    20. The expression of GFRA1 in normal infants and normoganglionic colon of patients with Hirschsprung's disease was restricted to receptor tyrosine kinase(RET)-negative glial cells and RET-positive neurons of the ganglionic plexus. PMID: 12065680
    21. GFRA1-193C > G and 537T > C could be in linkage disequilibrium with other loci responsible for medullary thyroid cancer PMID: 12490080
    22. analysis of binding surface for the GDNF-GFR alpha 1 PMID: 14514671
    23. GFRalpha-1 were observed within sensory and motor nuclei of cranial nerves, dorsal column nuclei, olivary nuclear complex, reticular formation, pontine nuclei, locus caeruleus, raphe nuclei, substantia nigra, and quadrigeminal plate. PMID: 17825269
    24. GDNF can act as an important component of the inflammatory response in breast cancers and its effects aare mediated by GFR alpha 1 receptors. PMID: 18089803
    25. GDNF is a key component to preserve several cell populations in the nervous system and also participates in the survival and differentiation of peripheral neurons. PMID: 18394855
    26. 38 cases of germ cell tumors: 26 cases contained immature teratoma, of which 24 had immature neuroepithelium and showed strong membrane staining for GFRalpha-1. staining for GFRalpha-1 in immature neuroepithelium may facilitate its identification. PMID: 19019765

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus, trans-Golgi network. Endosome. Endosome, multivesicular body.
  • 蛋白家族:
    GDNFR family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4243

    OMIM: 601496

    KEGG: hsa:2674

    STRING: 9606.ENSP00000393725

    UniGene: Hs.388347



主站蜘蛛池模板: 亚洲中文字幕在线第二页| 成 人免费va视频| 国产成人涩涩涩视频在线观看| 国产精品丝袜一区二区三区| 国产无遮挡a片又黄又爽| 老司机导航亚洲精品导航| 欧美肥臀大屁股magnet| 久久久久成人片免费观看蜜芽| 国产女人和拘做受视频免费| 国产精品不卡无码av在线播放 | 天干夜天干天天天爽视频| 狠狠色狠狠色综合日日不卡 | 亚洲成在人线av无码| 亚洲a综合一区二区三区| av无码中出一区二区三区| 麻豆国产av尤物网站尤物| 色婷婷综合久久久中文字幕| 美女露出奶头扒开尿口免费网站| 国产在线观看精品一区二区三区| 无码被窝影院午夜看片爽爽jk | 国产精品亚洲第一区在线观看| 精品1卡二卡三卡四卡老狼| 九色九九九老阿姨| 永久免费男同av无码入口| 午夜福利视频1692| 久久婷婷人人澡人人爽人人爱| 国产综合色在线视频区| 九色精品国产成人综合网站| 色偷偷色噜噜狠狠网站年轻人| 国产成人精品一区二区在线小狼 | 成年无码动漫av片在线观看羞羞| 亚色九九九全国免费视频| 日本乱码伦午夜福利在线| 国产乱xxxxx97国语对白| 日产精品卡二卡三卡四卡乱码视频| 成人a毛片视频免费看| 14萝自慰专用网站| 国产老熟女网站| 日韩高清成片免费视频| 国产欧美精品一区二区色综合 | 国产在线看片免费视频|