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GFM1 Antibody

  • 中文名稱:
    GFM1兔多克隆抗體
  • 貨號(hào):
    CSB-PA009373GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    GFM1
  • 別名:
    COXPD1 antibody; EF-Gmt antibody; EFG antibody; EFG1 antibody; EFGM antibody; EFGM_HUMAN antibody; EGF1 antibody; Elongation factor G 1 antibody; Elongation factor G 1 mitochondrial antibody; Elongation factor G antibody; Elongation factor G1 antibody; FLJ12662 antibody; FLJ13632 antibody; FLJ20773 antibody; G elongation factor mitochondrial 1 antibody; G translation elongation factor mitochondrial antibody; GFM 1 antibody; GFM antibody; gfm1 antibody; hEFG1 antibody; mEF G 1 antibody; mEF-G 1 antibody; mEFG 1 antibody; mitochondrial antibody; Mitochondrial elongation factor G1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human GFM1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
  • 基因功能參考文獻(xiàn):
    1. Functional studies demonstrated decreased GFM1 protein levels, suggested disrupted assembly of mitochondrial complexes III and V and decreased activities of mitochondrial complexes I and IV, all indicating combined OXPHOS deficiency. PMID: 28216230
    2. In the present study, a nanoparticle modified with EGFP-EGF1 (ENP) was constructed as a multitargeting drug delivery system. The protein binding experiment showed EGFP-EGF1 could bind well to A549 tumor cells and other stromal cells including neo-vascular cells, tumor-associated fibroblasts, and tumor-associated macrophages PMID: 26890991
    3. The R671C mutation disrupts an inter-subunit interface and could locally destabilize the mutant protein. The second mutation (L398P) disrupted the H-bond network in a rich-beta-sheet domain, and may have a dramatic effect on local structure. PMID: 21986555
    4. analysis of molecular model for EF-G1 isoform PMID: 15358359
    5. Sequencing of EFG1 revealed a mutation affecting a conserved residue of the guanosine triphosphate (GTP)-binding domain. These results define a new class of gene defects underlying disorders of oxidative phosphorylation. PMID: 15537906
    6. mutations in the mitochondrial translation factor EFG1 may have a role in oxidative phosphorylation deficiencies [case report] PMID: 16632485
    7. Genetic investigation of patients with defective mitochondrial translation led to the discovery of novel mutations in the mitochondrial elongation factor G1 (EFG1) in one affected baby and in the mitochondrial elongation factor Tu (EFTu) in another one PMID: 17160893

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  • 相關(guān)疾病:
    Combined oxidative phosphorylation deficiency 1 (COXPD1)
  • 亞細(xì)胞定位:
    Mitochondrion.
  • 蛋白家族:
    TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 13780

    OMIM: 606639

    KEGG: hsa:85476

    STRING: 9606.ENSP00000419038

    UniGene: Hs.518355



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