在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GEMIN2 Antibody, FITC conjugated

  • 中文名稱:
    GEMIN2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA021329LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GEMIN2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GEMIN2
  • 別名:
    Component of gems 2 antibody; Gem (nuclear organelle) associated protein 2 antibody; Gem associated protein 2 antibody; GEMI2_HUMAN antibody; Gemin-2 antibody; gemin2 antibody; SIP 1 antibody; SIP-1 antibody; SIP1 antibody; SIP1 delta antibody; SIP1-delta antibody; SMN interacting protein 1 antibody; SMN interacting protein 1 delta antibody; SMN-interacting protein 1 antibody; Survival interacting protein 1 antibody; Survival of motor neuron protein interacting protein 1 antibody; Survival of motor neuron protein-interacting protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Gem-associated protein 2 protein (1-280AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound.
  • 基因功能參考文獻:
    1. Specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of human Gemin2. PMID: 27974620
    2. The authors propose that Gemin2 is a versatile hub for ribonucleoprotein exchange that functions broadly in RNA metabolism. PMID: 26828962
    3. investigate the oligomeric nature of the SMN.Gemin2 complexes from humans and fission yeast (hSMN.Gemin2 and ySMN.Gemin2) PMID: 26092730
    4. Two monoclonal antibodies against SMN (survival-of-motor-neurons) protein bind to its site of interaction with gemin2. PMID: 23939045
    5. several conserved SMN residues, including the sites of two SMA patient mutations, are not required for binding to Gemin2. Instead, they form a conserved SMN/Gemin2 surface that may be functionally important for snRNP assembly. PMID: 22607171
    6. Overexpression of SIP1 and downregulation of E-cadherin is associated with delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy PMID: 21913013
    7. purified SMN-GEMIN2 fusion protein enhanced the RAD51-mediated homologous pairing much more efficiently than GEMIN2 alone PMID: 21732698
    8. Study identified Gemin2 as the protein that binds a pentamer of Sm proteins comprised of SmD1/D2 and SmF/E/G; the crystal structure of this complex bound to SMN's Gemin2 binding domain to 2.5 A was determined. PMID: 21816274
    9. Novel monoclonal antibodies detect SIP1 in the cytoplasm of human cells from multiple tumor tissue arrays. PMID: 20515682
    10. This study demonstrated that miR-141 levels correlate inversely with SIP1 protein levels as well as cell migration and invasion of CRC cells; SIP1 was identified as a functional target of miR-141. PMID: 19830559
    11. This study supports the rationale for developing SIP1 as a potential therapeutic and diagnostic target for gliomas PMID: 19806322
    12. SIP1 appears to stabilize functional multimer forms of IN, thereby promoting the assembly of IN and RT on viral RNA to allow efficient reverse transcription, which is a prerequisite for efficient HIV-1 infection PMID: 19915660
    13. Spinal muscular atrophy and amyotropic lateral sclerosis patients have decreased SIP 1-alpha and increased SIP 1-beta expression levels compared to normal tissues. PMID: 11943600
    14. SIP1 determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy. PMID: 15964810
    15. binds to HIV-1 integrase and facilitates viral cDNA synthesis and subsequent steps that precede integration in vivo PMID: 16731905
    16. Gemin2 plays an important role in small nuclear ribonucleoprotein assembly through the stabilization of the survival of motor neuron oligomer/complex via novel self-interaction PMID: 17308308
    17. relationship between the feature of gene mutations and single nucleotide polymorphisms of SIP1 gene and HSCR PMID: 18247312
    18. We found upregulation of mRNA for transcription factors Snail, Slug, Twist, and SIP1 in spindle cell carcinoma when compared to squamous cell carcinoma. PMID: 19381684

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.
  • 蛋白家族:
    Gemin-2 family
  • 數據庫鏈接:

    HGNC: 10884

    OMIM: 602595

    KEGG: hsa:8487

    STRING: 9606.ENSP00000308533

    UniGene: Hs.652307



主站蜘蛛池模板: 激情无码人妻又粗又大| 日产精品99久久久久久| 亚洲经典国产精华液单品榜| 人妻.中文字幕无码| 亚洲精品网站在线观看你懂的 | 中文字幕三级人妻无码视频| 久久精品香蕉绿巨人登场| 精品一区二区成人精品| 国产成人精品av| 人妻互换免费中文字幕| 国产麻豆9l精品三级站| 忘忧草日本在线www| 2021年精品国产福利在线| 久久国产精品久久久久久| 久久中文字幕人妻熟av女| 久久国产精品成人影院 | 日本三级在线观看免费| 国自产拍偷拍精品啪啪模特| 日本高清va在线播放| 日本一卡二卡四卡无卡国产| 一本无码久本草在线中文字幕dvd| 女人裸体做爰免费视频| 成人爱做日本视频免费| 欧洲亚洲1卡二卡三卡2021| 国产v在线最新观看视频| 巨大欧美黑人xxxxbbbb| 久久人人爽人人爽人人片av麻烦 | 欧美变态另类刺激| 国产寡妇偷人在线观看| 成人免费网站视频www| 性一交一黄一片| 亚洲精品成人久久久| 狠狠五月深爱婷婷网| 一个人看免费视频www| 免费无码又爽又刺激激情视频软件 | 人人超碰人摸人爱| 国产经典三级av在线播放| 狠狠做五月深爱婷婷伊人| 无码人妻av一二区二区三区| 国产成人久久综合77777| 伊人久久大香线焦av色|