在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GDF9 Antibody

  • 中文名稱:
    GDF9兔多克隆抗體
  • 貨號:
    CSB-PA009352EA01HU
  • 規格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA009352EA01HU diluted at 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GDF9 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    GDF9Growth/differentiation factor 9 antibody; GDF-9 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Growth/differentiation factor 9 protein (320-454AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,GDF9 Antibody (CSB-PA009352EA01HU),的標記方式是Non-conjugated。對于GDF9 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA009352EB01HU GDF9 Antibody, HRP conjugated ELISA
    FITC CSB-PA009352EC01HU GDF9 Antibody, FITC conjugated
    Biotin CSB-PA009352ED01HU GDF9 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
  • 基因功能參考文獻:
    1. The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses their potential role as markers of oocyte quality in women. PMID: 30039232
    2. Data suggest that GDF9 and BMP15 are oocyte-secreted factors with leading roles in control of ovarian function in female reproduction, modulating both fate of somatic granulosa cells and quality/developmental competence of the egg. (GDF9 = growth and differentiation factor-9; BMP15 = bone morphogenetic protein-15) [REVIEW] PMID: 29544636
    3. GDF9 single nucleotide polymorphism is not associated with Endometriosis-associated infertility. PMID: 28831646
    4. GDF9 single nucleotide polymorphism is associated with fecundity. PMID: 28762037
    5. Asiaticoside hindered the invasive growth of KFs by inhibiting the GDF-9/MAPK/Smad pathway. PMID: 28346732
    6. Human GDF9 and BMP15 act synergistically to stimulate granulosa cell proliferation, a response that also involves species-specific non-SMAD signalling pathways. PMID: 25155366
    7. these results indicated that the GDF9 C447T SNP is a possible candidate genetic risk factor for female infertility in the Polish population. PMID: 27035733
    8. GDF-9 promotes the proliferation and migration of keloid fibroblasts via a mechanism involving the Smad2/3 pathway. PMID: 27855376
    9. GDF9 c.169G>T (D57Y), c.546G>A (rs1049127), and BMP15 rs79377927 (788_789insTCT) were associated with premature ovarian failure in the Chinese Hui population. PMID: 25954833
    10. results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals. PMID: 26254468
    11. GDF-9 and GDF-15 levels may influence bone parameters in polycystic ovary syndrome PMID: 24430093
    12. GDF9 and BMP15 expression is reduced in primordial, primary, and secondary follicles in ovarian tissues of PCOS patients. PMID: 25172094
    13. The arginine residue in the pre-helix loop of GDF9 homodimer may prevent the inhibition from its pro-domain or directly alter receptor binding, but this residue in GDF9 does not significantly affect the heterodimer activity. PMID: 25253739
    14. Eleven unique copy number changes are identified in a total of 11 patients, including a tandem duplication of 475 bp, containing part of the GDF9 gene promoter region. PMID: 24939957
    15. Data suggest up-regulation of mRNA for GDF9 and BMP15 (bone morphogenetic protein 15) in cumulus granulosa cells serves as biomarker for oocyte maturation, fertilization, embryo quality, and pregnancy in couples undergoing ICSI for male infertility. PMID: 25139161
    16. These results suggest that COCs cultured with recombinant GDF9 in oocyte maturation medium improve oocyte developmental competence and subsequent developmental competence of cloned embryo in cattle. PMID: 24840335
    17. Reduced expression of growth and differentiation factor-9 is associated with aggressive behaviour of clear-cell renal cell carcinoma. PMID: 25368253
    18. Oocyte-derived GDF9 does not alter gap junction intercellular communication activity between human granulosa cells. PMID: 24413384
    19. Alterations to hGDF9 synthesis and activity can contribute to the most common ovarian pathologies. PMID: 24438375
    20. genetic association studies in population of Han women in China: Data suggest that a mutation in precursor region of GDF9 (R146C) is associated with premature ovarian failure (POF); R146C mutation found in 3 women with POF but absent in controls. PMID: 23851219
    21. FOXL2 expression is required for GDF-9 stimulation of follistatin transcription. PMID: 23523567
    22. BMP15 and GDF9 transcript levels increase in mature oocytes from women with polycystic ovary syndrome after ovarian stimulation, and might inhibit the progesterone secretion by follicular cells PMID: 22825968
    23. findings that GDF9:BMP15 heterodimers are the most bioactive ligands in mice and humans compared with homodimers explain many puzzling genetic and physiological data and have important implications for improving female fertility in mammals PMID: 23382188
    24. CDC6 and GDF-9 might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma. PMID: 23011157
    25. It was shown that human kidney tumours have a reduced or loss of expression of GDF9. In vitro, GDF9 overexpression suppresses the invasiveness, growth and migration of kidney cancer cells. PMID: 23060562
    26. GDF-9 levels are inversely correlated with the growth, adhesion and migration of bladder cancer cells in vitro. PMID: 22159313
    27. GDF9 may contribute to the variation observed in follicular development, ovulation rate, and fecundity between mammals PMID: 22234469
    28. GDF9 decreases basal and activin A-induced FST and FSTL3 expression, and this explains, in part, its enhancing effects on activin A-induced inhibin beta(B)-subunit mRNA expression and inhibin B production in hGL cells PMID: 21829661
    29. In the samples from girls/women, the number of developing follicles was greater with GDF9 or BMP15 alone than with no BMP15 or GDF9. PMID: 21632818
    30. The expression of GDF9 and BMP15 in oocytes from patients with polycystic ovary syndrome cannot reach the normal level even after ovarian stimulation. PMID: 21669410
    31. Higher mature GDF9 levels in the follicular fluid were significantly correlated with oocyte nuclear maturation and embryo quality. PMID: 21496799
    32. GDF-9 signaling via ALK-5, can promote cell invasiveness PMID: 21116689
    33. Integral role of GDF-9 and BMP-15 in ovarian function. PMID: 21226076
    34. GDF-9 can promote the motile and adhesive capacity of PC-3 prostate cancer cells by up-regulating expression of FAK and paxillin in a Smad dependent manner, suggesting a pro-tumourigenic role for GDF-9 in prostate cancer. PMID: 21042764
    35. Impaired production of BMP15 and GDF9 mature proteins derived from proproteins with mutation in the proregion. PMID: 20547206
    36. Mutational analysis of the coding region of GDF9 among 216 Chinese polycystic ovary syndrome patients. Five novel missense mutations were discovered namely c.15C>G, c.118T>G, c.133A>G, c.1025A>T and c.1275C>A. PMID: 20705511
    37. The detection of GDF9 and TGFbetaR1 at both at the protein and mRNA levels suggests that GDF9 may have functions in human preantral follicles. PMID: 20427239
    38. GDF-9 c.G546A, but not c.G169A or c.C447T, is correlated with the poor ovarian stimulation and in vitro fertilization outcomes in women with diminished ovarian reserve. PMID: 20451184
    39. GDF9 attenuates the suppressive effects of activin A on StAR expression and progesterone production by increasing the expression of inhibin B, which acts as an activin A competitor. PMID: 20660033
    40. Cell growth was significantly increased in the GDF9 over-expressing cells compared to the two controls; apoptosis was decreased in the presence of GDF9. PMID: 20458753
    41. GDF-9 concentration in women with severe endometriosis was lower than in those without PMID: 19931079
    42. data demonstrate that polymorphisms in major folliculogenesis genes, GDF9, BMP15, AMH, and AMHR2, are not associated with polycystic ovary syndrome susceptibility. PMID: 20236105
    43. Reduced GDF-9 expression in cumulus granulosa cells of patients with polycystic ovary syndrome (PCOS) appears to be associated with decreased long-term developmental potential of the oocytes of patients with PCOS. PMID: 19376510
    44. Data show that Golgi apparatus casein kinase (G-CK) catalyzes the phosphorylation of rhBMP-15 and rhGDF-9. PMID: 20067794
    45. 2 synonymous mutations (c.447C>T, c.546G>A) & a novel missense variant (c.169G>T) were found in both premature ovarian failure patients & control subjects in the coding region of GDF9, indicating them as a novel polymorphism PMID: 19438907
    46. Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9 PMID: 12135884
    47. interaction with bone morphogenetic protein-15 PMID: 12446716
    48. BMP-15 and GDF-9 have roles in fertility; critical sequences are determined by mutagenesis PMID: 14970198
    49. This case-control study revealed eight mutations in the GDF9 gene in women with premature ovarian failure PMID: 16278619
    50. although mutations in BMP15 and GDF9 are not a major cause of ovarian insufficiency, they may be involved in premature ovarian failure PMID: 16645022

    顯示更多

    收起更多

  • 相關疾病:
    Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins.
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    TGF-beta family
  • 組織特異性:
    Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level).
  • 數據庫鏈接:

    HGNC: 4224

    OMIM: 601918

    KEGG: hsa:2661

    STRING: 9606.ENSP00000296875

    UniGene: Hs.25022



主站蜘蛛池模板: 亚洲成国产人片在线观看| 成人网站国产在线视频内射视频| 又爽又黄无遮挡高潮视频网站| 久久久久人妻一区精品果冻| 日本中文字幕乱码免费| 小鲜肉自慰网站| 狠狠综合久久久久尤物丿| 天堂中文8资源在线8| 高潮喷吹一区二区在线观看| 制服丝袜有码中文字幕在线| 中文字幕人妻丝袜成熟乱 | 亚洲国产成人无码av在线影院| 欧美性猛交xxxx三人| 欧美另类精品xxxx| 久久国产一区二区三区| 国产精品永久免费视频| 国产高清无套内谢| 2021久久超碰国产精品最新| 天堂а在线中文在线新版| 99精品偷自拍| 18禁黄网站禁片免费观看国产 | 日本一丰满一bbw| 亚洲精品国产一区黑色丝袜| 无码人妻精一区二区三区| 护士脱了内裤让我爽了一夜视频 | 久久久久亚洲精品男人的天堂| 国产亚洲精品欧洲在线视频| 97se亚洲精品一区二区| 亚洲 国产 韩国 欧美 在线| 久久99精品久久久久久动态图| av无码中文一区二区三区四区| 欧美一性一乱一交一免费视频| 亚洲视频日韩视欧美视频| 无码人妻aⅴ一区二区三区| 人妻另类 专区 欧美 制服| 亚洲曰本av在线天堂| 亚洲男男无套gv大学生| 特级毛片在线大全免费播放| 日本不卡一区二区三区在线| 国产亚洲精品久久久久久国| 大香网伊人久久综合网2018|