在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GDF6 Antibody

GDF6 Antibody

  • 中文名稱：
    GDF6兔多克隆抗體
  • 貨號：
    CSB-PA006333
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of RAT-kidney cells using GDF-6 Polyclonal Antibody
    • Western Blot analysis of rat kidney cells using GDF-6 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    GDF6 antibody; BMP13 antibody; GDF16Growth/differentiation factor 6 antibody; GDF-6 antibody; Bone morphogenetic protein 13 antibody; BMP-13 antibody; Growth/differentiation factor 16 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GDF-6.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38.
  • 基因功能參考文獻：
    1. findings indicate that increased BMP signaling owing to a GDF6 gain-of-function mutation is responsible for loss of joint formation and profound functional impairment in patients with Multiple Synostoses Syndrome 4. PMID: 26643732
    2. As fetal age increased, the expression of growth differentiation factor 6 was decreased correspondingly with the progress of ossification in vertebral bodies and restricted to cartilaginous regions. PMID: 26184900
    3. BMP13 has a role in enhancing extracellular matrix accumulation and inducing cell migration in certain intervertebral disc cells PMID: 26134557
    4. GDF6 is overexpressed in Leri's pleonosteosis. PMID: 24442880
    5. There was a possible weak association between the rs6982567 near GDF6 and polypoidal choroidal vasculopathy in this replication study with an independent Han Chinese cohort. PMID: 25416513
    6. Deficiency of gdf6 results in photoreceptor degeneration, so demonstrating a connection between Gdf6 signaling and photoreceptor survival. PMID: 23307924
    7. a critical role of HTRA1 in the regulation of angiogenesis via TGF-beta signaling and identified GDF6 as a novel disease gene for AMD. PMID: 22049084
    8. studies show that even though tenogenic (BMP 12 and BMP 13) and osteogenic (BMP2) BMPs bind the same receptors with high affinity they signal much differently and result in differential activation of osteogenic and tenogenic markers PMID: 21702718
    9. induces ligamentogenic differentiation in mesenchymal progenitors PMID: 20334610
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 20734064
    11. These data suggest a potential role for BMP-13 (the human homologue to GDF-6) in tendon matrix modeling and/or remodeling. PMID: 19492402
    12. Observational study of gene-disease association. (HuGE Navigator) PMID: 20494911
    13. The spectrum of disorders generated by morpholino inhibition and the more severe defects (microphthalmia and anophthalmia) observed at higher doses illustrate the key role of GDF6 in ocular development. PMID: 17236135
    14. Mutation screening of a large and clinically diverse Klippel-Feil syndrome (KFS) cohort has identified GDF6 missense mutations in both familial and sporadic KFS patients. PMID: 18425797
    15. These data establish the important role of growth differentiation factor 6 in ocular and vertebral development. PMID: 19129173
    16. BMP-13 inhibited osteogenic differentiation of bone marrow multipotent mesenchymal stromal cells, implying that functional mutations or deficiency of BMP-13 may allow excess bone formation PMID: 19240811
    17. Observational study of gene-disease association. (HuGE Navigator) PMID: 20057906
    18. Observational study of gene-disease association. (HuGE Navigator) PMID: 18716610

    顯示更多

    收起更多

  • 相關疾病：
    Klippel-Feil syndrome 1, autosomal dominant (KFS1); Microphthalmia, isolated, 4 (MCOP4); Leber congenital amaurosis 17 (LCA17)
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 數據庫鏈接：

    HGNC: 4221

    OMIM: 118100

    KEGG: hsa:392255

    STRING: 9606.ENSP00000287020

    UniGene: Hs.492277



主站蜘蛛池模板： 99国产欧美久久久精品| 久久香综合精品久久伊人| 两性色午夜视频免费老司机| 日本乱亲伦视频中文字幕| 久久国产精品久久精品国产| 国产精品毛片a∨一区二区三区 | 亚洲综合色噜噜狠狠网站超清| 日韩精品无码中文字幕一区二区 | 在线观看高清黄网站观看| 欧美潮喷少妇100| 伦伦影院午夜理论片| 一本本月无码-| 春药玩弄少妇高潮吼叫| 国产av偷闻女邻居内裤被发现| 国产在线精品一区在线观看| 18禁黄污吃奶免费看网站| 亚洲色大成网站www永久麻豆| 精品无码一区在线观看| 思思99热久久精品在线6| 成年女性特黄午夜视频免费看| 很色很爽很黄裸乳视频| 亚洲va久久久噜噜噜久久男同| 羞涩的丰满人妻40p| 热99re久久精品这里都是精品| 国产精品vⅰdeoxxxx国产| 欧美国产激情一区二区在线| 亚洲午夜久久久无码精品网红a片| 国产亚洲欧美在线专区| 自愉自愉产区二十四区| 色avav色av爱avav亚洲色拍| 2019国产品在线视频| 青青草国产成人99久久| 国内精品美女视频免费直播| 免费无码黄十八禁网站在线观看 | 久久久无码精品午夜| 潮喷大喷水系列无码久久精品| 国产成人涩涩涩视频在线观看| 亚洲一区av无码少妇电影| 亚在线第一国产州精品99| 伊人久久大香线蕉综合中文字幕| 精品无码人妻一区二区三区不卡|