在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GDF11 Antibody, Biotin conjugated

  • 中文名稱:
    GDF11兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA009344LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GDF11 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    BMP 11 antibody; BMP-11 antibody; BMP11 antibody; Bone morphogenetic protein 11 antibody; GDF 11 antibody; GDF-11 antibody; Gdf11 antibody; GDF11_HUMAN antibody; Growth differentiation factor 11 antibody; Growth/differentiation factor 11 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Growth/differentiation factor 11 protein (299-407AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.
  • 基因功能參考文獻:
    1. The serum content of GDF11 was much less in esophageal cancer patients than in the control group. Esophageal GDF II in cancer patients was correlated with cancer differentiation: the higher the degree of differentiation, the higher the content of GDF11. PMID: 30213293
    2. Physical inactivity was significantly related to the decreased GDF11 levels in COPD. PMID: 29731621
    3. GDF11 expression was decreased in COPD patients' serum and cells when compared with that of healthy people. PMID: 29680737
    4. GDF11 may be a relevant myostatin-interacting peptide to successful aging in humans PMID: 28701523
    5. The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in tissue specific aging. PMID: 28472635
    6. Tumor-suppressor inactivation of GDF11 occurs by precursor sequestration in triple-negative breast cancer PMID: 29161592
    7. These studies identify distinctive structural features of GDF11 that enhance its potency, relative to GDF8; however, the biological consequences of these differences remain to be determined. PMID: 28257634
    8. In elderly Chinese women, osteoporosis risk was significantly increased with increases in GDF11 serum levels. PMID: 27557752
    9. A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble PMID: 28715204
    10. MSTN, but not GDF11, declines in healthy men throughout aging. PMID: 27304512
    11. GDF11 is highly concentrated in human platelets. PMID: 27509407
    12. The crystal structure of GDF11 was determined to a resolution of 1.50 A. PMID: 26919518
    13. GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues. It functions in the heart, skeletal muscle, and brain. Review. PMID: 27034275
    14. GDF11 inhibits rather than helps muscle regeneration. PMID: 26001423
    15. Show that there is no age-related cardiac hypertrophy in disease-free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function. PMID: 26383970
    16. in vitro sprout formation was increased as well by GDF11 treatment PMID: 26026854
    17. Suggest GDF11 functions as encephalic regionalizing factor in neural differentiated mouse embryonic stem cells. PMID: 25352416
    18. GDF11 is a critical rheostat for bone turnover and a key integrator of bone homeostasis. PMID: 25534870
    19. These data demonstrate GDF11 to be a master regulator of neural stem cell transcription that can suppress cell proliferation and migration by regulating the expression of numerous genes involved in both these processes PMID: 24244313
    20. Expression of GDF11, a cytokine which blocks terminal erythroid maturation, was increased in erthyroblasts of thalassemic patients. PMID: 24658077
    21. Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue PMID: 17912435
    22. Members of the transforming growth factor beta (TGFbeta) superfamily, bone morphogenetic protein 2 (BMP2), and growth and differentiation factor 11 (GDF11), can signal cultured RGCs to form dendrites. PMID: 17997109
    23. We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development. PMID: 18519639
    24. Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin. PMID: 18535106
    25. Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. PMID: 18596030
    26. Myostatin or 20 ng/mL BMP-11 maintain the colony and cellular morphology of undifferentiated hESC, maintain POU5f1, NANOG, TRA-1-60, and SSEA4 expression, and display increased SMAD2/3 phosphorylation PMID: 19751112

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    TGF-beta family
  • 組織特異性:
    In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme.
  • 數據庫鏈接:

    HGNC: 4216

    OMIM: 603936

    KEGG: hsa:10220

    STRING: 9606.ENSP00000257868

    UniGene: Hs.600883



主站蜘蛛池模板: 少妇人妻中文字幕hd| 久久久老熟女一区二区三区| 伊人久久大香线蕉avapp下载| 久久男人av资源网站| 无码专区—va亚洲v专区| 成人aaa片一区国产精品| 日本熟妇大乳| 免费的av网站在线观看国产精品 | 中文字幕人乱码中文字幕| 高清欧美性猛交xxxx黑人猛交| 久久综合五月丁香久久激情| 中国老熟妇自拍hd发布| 国产丝袜一区视频在线观看| 天堂а√在线最新版中文在线| 色综合久久88色综合天天| 国产av无码专区亚洲草草| 日亚韩在线无码一区二区三区| 韩日午夜在线资源一区二区| 日本成熟老妇乱| 男女裸交无遮挡啪啪激情试看| 国产精品一区在线观看你懂的| 亚洲熟女乱色综合亚洲图片| 久久久精品久久日韩一区综合| 少妇无码av无码专区线y| 久久久久高潮毛片免费全部播放| 久久精品国产精品亚洲| 欧洲性久久精品| 欧美激烈精交gif动态图| 国产无遮挡又黄又爽在线观看| 人人妻人人爽人人做夜欢视频 | 777米奇色狠狠888俺也去乱| 亚洲精品www久久久久久| 国产午费午夜福利200集| 欧美极品色午夜在线视频 | 无码少妇一区二区浪潮av| 无码人妻精一区二区三区| 亚洲真人无码永久在线| 少妇人妻久久无码专区| 66亚洲一卡2卡新区成片发布| 精品人妻伦九区久久aaa片69| 疯狂迎合进入强壮公的视频|