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  4. GDF10 Antibody, Biotin conjugated

GDF10 Antibody, Biotin conjugated

  • 中文名稱：
    GDF10兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA009343LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GDF10 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GDF10
  • 別名：
    BIP antibody; BMP 3b antibody; BMP-3b antibody; BMP3B antibody; BMP3B_HUMAN antibody; Bone inducing protein antibody; Bone morphogenetic protein 3b [Precursor] antibody; Bone morphogenetic protein 3b antibody; Bone-inducing protein antibody; GDF 10 antibody; GDF-10 antibody; Gdf10 antibody; growth differentiation factor 10 antibody; Growth/differentiation factor 10 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Growth/differentiation factor 10 protein (369-478AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
  • 基因功能參考文獻：
    1. Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition. PMID: 25728212
    2. GDF10 is a stroke-induced signal for axonal sprouting and functional recovery. PMID: 26502261
    3. new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha PMID: 18077449
    4. BMP3b and BMP6 genes were suppressed by DNA methylation and methylation of BMP3b is significantly frequent in Japanese malignant pleural mesotheliomas (MPMs), suggesting its pathogenic role and the ethnic difference in MPMs. PMID: 18949431
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 組織特異性：
    Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
  • 數據庫鏈接：

    HGNC: 4215

    OMIM: 601361

    KEGG: hsa:2662

    STRING: 9606.ENSP00000224605

    UniGene: Hs.2171



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