1. Our results suggest that the GDF1 rs4808863 polymorphism contributes to an increased risk of fetal CHDs, especially the subtypes of AVSD, LVOTO and left-right laterality defects. PMID: 26656983
2. This implies that Gdf1 potentiates Nodal activity by stabilizing a low molecular weight fraction that is susceptible to neutralization by soluble Acvr2. PMID: 24798330
3. indicate that the expression of growth/differentiation factor 1 (GDF1) is up-regulated in human dilated cardiomyopathy (DCM)hearts and murine hypertrophic hearts. PMID: 24275554
4. GDF1 may be associated with congenital heart defects risk, and these variations contribute at least in part to the development of some subtypes of conotruncal defects in the Chinese Han population. PMID: 23076529
5. Molecular genetic basis of a kindred with 5 siblings with right atrial isomerism involved mutations in GDF1. PMID: 20413652
6. Heterozygous loss-of-function mutations in the human GDF1 gene contribute to cardiac defects ranging from tetralogy of Fallot to transposition of the great arteries. PMID: 17924340
7. GDF1 expression is correlated with progression and aggressive behaviors in cervical cancer, suggesting a tumor-promoting role for GDF1 in the progression of this malignancy. PMID: 19359031

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HGNC: 4214

OMIM: 187500

KEGG: hsa:2657

STRING: 9606.ENSP00000247005

UniGene: Hs.412355