在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GATM Antibody

GATM Antibody

  • 中文名稱：
    GATM兔多克隆抗體
  • 貨號(hào)：
    CSB-PA009284GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    GATM
  • 別名：
    AGAT antibody; AT antibody; GATM antibody; GATM_HUMAN antibody; Glycine amidinotransferase antibody; Glycine amidinotransferase, mitochondrial antibody; L-arginine:glycine amidinotransferase antibody; mitochondrial antibody; Transamidinase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human GATM
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
  • 基因功能參考文獻(xiàn)：
    1. Measurements of creatine and guanidinoacetate in plasma are recommended for the diagnosis of AGAT and GAMT deficiency.Definitive confirmation of the diagnosis requires DNA sequencing of the appropriate gene and (if molecular analysis is ambiguous) measurement of AGAT or GAMT enzyme activity or of CRTR-mediated transport . PMID: 28055022
    2. Results show the functional characterization of rare missense variants in GATM which cause GATM deficiency. Seven of them report 0% of wild-type GATM activity indicating a putative pathogenicity. PMID: 27233232
    3. AGAT deficiency is a treatable intellectual disability. PMID: 26490222
    4. Meta-analysis yielded a marginal, but null, association of GATM rs9806699 with statin-induced myopathy. PMID: 25863251
    5. Genome-wide association reveals that plasma homoarginine is strongly associated with single nucleotide polymorphisms in the AGAT gene. PMID: 24004504
    6. promiscuous activity of AGAT, a key enzyme in creatine synthesis, plays a pivotal role in homoarginine synthesis PMID: 23010440
    7. GATM sequencing revealed a homozygous single nucleotide insertion 1111_1112insA, producing a frame-shift at Met-371 and premature termination at codon 376. PMID: 20682460
    8. AGAT mRNA expression was significantly elevated in all heart failure patients and returned to normal levels after recovery, suggesting a specific response to heart failure involving elevated local creatine synthesis. PMID: 16820567

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Cerebral creatine deficiency syndrome 3 (CCDS3)
  • 亞細(xì)胞定位：
    [Isoform 1]: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Probably attached to the outer side of the inner membrane.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Amidinotransferase family
  • 組織特異性：
    Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4175

    OMIM: 602360

    KEGG: hsa:2628

    STRING: 9606.ENSP00000379895

    UniGene: Hs.560354



主站蜘蛛池模板： 日日鲁鲁鲁夜夜爽爽狠狠| 国产精品偷伦视频免费观看了| a一区二区三区乱码在线 | 欧洲 | 日本阿v网站在线观看中文| 无码av中文字幕久久专区| 真实国产乱子伦视频| 国产高清一区二区三区直播| 露脸叫床粗话东北少妇| 色欲av永久无码精品无码蜜桃| 最新色国产精品精品视频| 亚洲成αv人片在线观看| 黑人巨大精品欧美一区二区免费| 久久精品中文字幕无码绿巨人| 国产区精品系列在线观看| 亚洲国产成人精品无码区二本| 少妇人妻偷人激情视频| 婷婷久久综合九色综合88| 人妻精品制服丝袜久久久| 久久成人网站亚洲综合| 国产男女猛烈无遮挡免费视频| 免费看无码毛视频成片| 四虎影在永久在线观看| 亚洲精品无码av中文字幕| 亚洲精品久久无码av片| 日日av色欲香天天综合网| 免费永久在线观看黄网站| 国产成人精品一区二三区| 欧美成人秋霞久久aa片| 影音先锋无码a∨男人资源站| 久久久日韩精品一区二区三区| 国产精品兄妹在线观看麻豆| 人与人性恔配视频免费| 欧美巨大xxxx做受中文字幕| 成年美女黄网站色大片免费看 | 大陆极品少妇内射aaaaaa| 国产内射999视频一区| 国产男女猛烈视频在线观看| 思思久久99热只有频精品66| 午夜无码乱码在线观看| 樱花草在线社区www日本影院| 日韩精品亚洲人成在线观看|