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GAS2 Antibody

  • 中文名稱：
    GAS2兔多克隆抗體
  • 貨號：
    CSB-PA009265LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, Rat liver tissue
      All lanes: GAS2 antibody at 3.3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 35, 16 kDa
      Observed band size: 35 kDa
    • IHC image of CSB-PA009265LA01HU diluted at 1:1000 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GAS2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GAS2
  • 別名：
    GAS 2 antibody; GAS-2 antibody; Gas2 antibody; GAS2_HUMAN antibody; Growth arrest specific 2 antibody; Growth arrest specific protein 2 antibody; Growth arrest-specific protein 2 antibody; MGC32610 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human Growth arrest-specific protein 2 protein (1-141AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，GAS2 Antibody (CSB-PA009265LA01HU)，的標記方式是Non-conjugated。對于GAS2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA009265LB01HU GAS2 Antibody, HRP conjugated ELISA
    FITC CSB-PA009265LC01HU GAS2 Antibody, FITC conjugated
    Biotin CSB-PA009265LD01HU GAS2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:1000-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.
  • 基因功能參考文獻：
    1. Taken together, our results demonstrated the deregulation of GAS2 in both AML and ALL and the requirement of GAS2-Calpain2 axis for the growth of leukemic cells. PMID: 26358320
    2. Truncated HBx deregulates cell growth via direct silencing of GAS2 and thereby provides a survival advantage for pre-neoplastic hepatocytes to facilitate cancer development via TP53 signaling. PMID: 25925944
    3. GAS2 is up-regulated in chronic myeloid leukemia cells. PMID: 24465953
    4. Studies have identified a Gas2/calpain-dependent mechanism by which ICSBP influences beta-catenin activity in myeloid leukemia. PMID: 20679491
    5. Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin PMID: 15817486

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton, stress fiber. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    GAS2 family
  • 組織特異性：
    Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
  • 數據庫鏈接：

    HGNC: 4167

    OMIM: 602835

    KEGG: hsa:2620

    STRING: 9606.ENSP00000278187

    UniGene: Hs.711297



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