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  4. GAREM1 Antibody, FITC conjugated

GAREM1 Antibody, FITC conjugated

  • 中文名稱：
    GAREM1兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA863993LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GAREM1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GAREM1
  • 別名：
    GAREM1 antibody; C18orf11 antibody; FAM59A antibody; GAREM antibody; GRB2-associated and regulator of MAPK protein 1 antibody; GRB2-associated and regulator of MAPK1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human GRB2-associated and regulator of MAPK protein (12-320AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.
  • 基因功能參考文獻：
    1. We have provided evidence that GAREM1 is involved in the PR interval of ECGs. These findings increase our understanding of the regulatory signals of heart rhythm through intracardiac ganglia of the autonomic nervous system and can be used to guide the development of a therapeutic target for heart conditions, such as atrial fibrillation. PMID: 29273731
    2. suggest that the interplay between 14-3-3, SAM domain and CABIT domain might be responsible for the distribution of GAREM1 in mammalian cells. PMID: 26164232
    3. Data indicate that a subtype of GAREM, GAREM2, is specifically expressed in the mouse, rat, and human brain. PMID: 24003223
    4. Extracellular signal-regulated kinase activation in response to epidermal growth factor stimulation is regulated by the expression of GAREM in COS-7 and HeLa cells. PMID: 19509291
  • 蛋白家族：
    GAREM family
  • 組織特異性：
    Isoform 1 is ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 26136

    KEGG: hsa:64762

    UniGene: Hs.444314



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