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  4. GAR1 Antibody, Biotin conjugated

GAR1 Antibody, Biotin conjugated

  • 中文名稱：
    GAR1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA878917LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GAR1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GAR1
  • 別名：
    Gar1 antibody; GAR1_HUMAN antibody; H/ACA ribonucleoprotein complex subunit 1 antibody; nucleolar protein family A member 1 (H/ACA small nucleolar RNPs) antibody; Nucleolar protein family A member 1 antibody; snoRNP protein GAR1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human H/ACA ribonucleoprotein complex subunit 1 protein (1-217AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
  • 基因功能參考文獻：
    1. The deregulated expression and function of H/ACA snoRNPs may underlie specific pathological features of human disease. PMID: 23707062
    2. The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modification. PMID: 19917616
    3. heterozygous point mutations in NOLA1 gene are not responsible for aplastic anemia in our patients at least acting via telomere PMID: 18989882
  • 亞細胞定位：
    Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
  • 蛋白家族：
    GAR1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14264

    OMIM: 606468

    KEGG: hsa:54433

    STRING: 9606.ENSP00000226796

    UniGene: Hs.69851



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