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  4. GANAB Antibody

GANAB Antibody

  • 中文名稱：
    GANAB兔多克隆抗體
  • 貨號：
    CSB-PA008333
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of LOVO cells using Glucosidase IIα Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Alpha glucosidase II alpha subunit antibody; Alpha-glucosidase 2 antibody; G2AN antibody; GANAB antibody; GANAB_HUMAN antibody; Glu II antibody; Glucosidase alpha neutral AB antibody; Glucosidase II alpha antibody; Glucosidase II subunit alpha antibody; GluII antibody; KIAA0088 antibody; Neutral alpha glucosidase AB antibody; Neutral alpha glucosidase AB precursor antibody; Neutral alpha-glucosidase AB antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Glucosidase IIα.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.
  • 基因功能參考文獻：
    1. Case Report: GANAB mutation leading to autosomal dominant polycystic kidney disease. PMID: 28784653
    2. Mutations in GANAB gene is associated with Autosomal-Dominant Polycystic Kidney and Liver Disease. PMID: 27259053
    3. The high frequency of glucosidase II overexpression, which to the best of our knowledge has not been previously described, indicates its crucial roles in lung tumorigenesis and is thus a valuable biomarker PMID: 24008518
    4. Loss of the tumor suppression function of Hsp60 or GANAB contribute to aggressive cancers. PMID: 21642380
    5. In males being treated for infertility, neutral alpha-glucosidase activity correlated with the percentage of sperm DNA fragmentation. PMID: 19737279
    6. the apparent occurrence of an unusual TG 3' splice site in intron 18 is discussed PMID: 17672918

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  • 相關疾病：
    Polycystic kidney disease 3 (PKD3)
  • 亞細胞定位：
    Endoplasmic reticulum. Golgi apparatus. Melanosome.
  • 蛋白家族：
    Glycosyl hydrolase 31 family
  • 組織特異性：
    Detected in placenta. Isoform 1 and isoform 2 are expressed in the kidney and liver.
  • 數據庫鏈接：

    HGNC: 4138

    OMIM: 104160

    KEGG: hsa:23193

    STRING: 9606.ENSP00000340466

    UniGene: Hs.595071



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