在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GALNT2 Antibody

  • 中文名稱:
    GALNT2兔多克隆抗體
  • 貨號:
    CSB-PA605995ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: GALNT2 antibody at 4.38µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: Jurkat whole cell lysate
      Lane 3: HepG2 whole cell lysate
      Lane 4: A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 65, 31 kDa
      Observed band size: 65 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA605995ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA605995ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GALNT2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GALNT2
  • 別名:
    GalNAc T2 antibody; GalNAc-T2 antibody; Galnt2 antibody; GALT2_HUMAN antibody; GaNTase 2 antibody; Polypeptide GalNAc transferase 2 antibody; Polypeptide N acetylgalactosaminyltransferase 2 antibody; Polypeptide N acetylgalactosaminyltransferase 2 soluble form antibody; Polypeptide N-acetylgalactosaminyltransferase 2 soluble form antibody; pp GaNTase 2 antibody; pp-GaNTase 2 antibody; Protein UDP acetylgalactosaminyltransferase 2 antibody; Protein-UDP acetylgalactosaminyltransferase 2 antibody; UDP GalNAc transferase 2 antibody; UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 2 (GalNAc T2) antibody; UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 2 antibody; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 2 protein (442-571AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism.
  • 基因功能參考文獻:
    1. GALNT2 rs12040273 variants might not be associated with the susceptibility of coronary artery disease or its severity in a Chinese Han population. The CC genotype could be associated with elevated serum HDL-C levels. PMID: 29351739
    2. Our results indicate that GALNT2 suppresses the malignant potential of gastric adenocarcinoma cells PMID: 26848976
    3. The crystal structure of GalNAc-T2 with the galactose derivative traps the enzyme in an inactive form; this suggests that compounds only containing the beta-phosphate could be efficient ligands for the enzyme. Computational studies with GalNAc-T2 corroborate these findings and provide further insights into the mechanism of the catalytic cycle of this family of enzymes. PMID: 27071848
    4. These results posit GALNT2 as a direct modulator of high density lipoprotein metabolism across mammals. PMID: 27508872
    5. Our data suggest a role of GALNT2 expression changes on serum triglycerides. PMID: 26239958
    6. This study demonstrates that the polypeptide GalNAc-transferase 2 (GalNAc-T2) specifically O-glycosylates beta 1-adrenergic receptor at five residues in the extracellular N terminus, including the Ser-49 residue at the location of the common S49G single-nucleotide polymorphism. PMID: 28167537
    7. The presence of lectin domain T3lec or T4lec during ppGalNAc-T2 and ppGalNAc-T3 catalytic reaction had a clear inhibitory effect on GalNAc-T activity. PMID: 27738109
    8. Possible inter-locus interactions among the DOCK7, PCSK9 and GALNT2 SNPs were also noted. PMID: 26493351
    9. Differences in lipid profiles between the Jing and Han populations might partially attribute to the DOCK7, PCSK9 and GALNT2 gene polymorphisms and their haplotypes determining different risk for the development of cardiovascular diseases. PMID: 26744084
    10. The results suggest that rs4846913 and rs2144300 drive the association to HDL-C plasma levels through an inhibitory regulation of GALNT2. PMID: 26817450
    11. The present work indicates that SNP rs4846914 in GALNT2 gene is related to an increased risk of hypertension in China Han population, but the APOE gene is not. PMID: 26405973
    12. Multiple hepatic regulatory variants at the GALNT2 GWAS locus have been found associated with high-density lipoprotein cholesterol. PMID: 26637976
    13. Downregulation of GALNT2 is associated with IgA nephropathy. PMID: 25744272
    14. Our findings suggest that GALNT2 regulates malignant phenotypes of neuroblastoma cells PMID: 25362349
    15. promoter DNA hypermethylation of the ABCG1 and GALNT2 genes, but not the HMGCR gene, is associated with an increased risk of CHD. PMID: 25084356
    16. genome-wide association study in population in Finland: Data suggest that one SNP in GALNT2 (rs6684432) and two SNPs in VDBP (vitamin D binding protein; rs7041, rs705117) are associated with serum levels of VDBP in the male population studied. PMID: 24740207
    17. findings suggest that GALNT2 plays an important role in the invasive behavior of OSCC and that targeting GALNT2 could be a promising approach for OSCC therapy PMID: 24582885
    18. GALNT2 is down-regulated in patients with type 2 diabetes PMID: 23894607
    19. Endoplasmic reticulum localization of GalNAc-T2 Is Sufficient to Drive High Tn Expression. PMID: 23912186
    20. ppGalNAc-T2 may exert anti-proliferative and anti-metastatic activity through the decrease of MMP-2 and TGF-beta1. PMID: 22992780
    21. Data suggest that GALNT2 and protein O-glycosylation are critical in extravillous trophoblast (EVT) invasion/placentation. GALNT2 is expressed in subpopulations of EVT in decidua; GALNT2 expression in EVT increases as pregnancy progresses. PMID: 23117232
    22. analysis of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol PMID: 22952570
    23. Studies indicate that three loci for lipid levels identified by GWAS has identified functional genes GALNT2, TRIB1, and SORT1, and a functional variant at SORT1. PMID: 22418572
    24. Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man. PMID: 22152306
    25. The status of the O-glycans attached to the EGFR was altered by GALNT2, changing EGFR responses after EGF binding. PMID: 21990321
    26. genetic association studies in rural populations in Guangxi, China: SNPs in GALNT2 (rs2144300; rs4846914) are associated with plasma lipid/lipoprotein levels in the general population; ethnic differences exist in Mulao and Han populations. PMID: 21933382
    27. these findings clearly indicate that biological activity (catalytic capacity and glycan-binding ability) of ppGalNAc-T2 is regulated by acetylation. PMID: 21651894
    28. Data show that SNPs associated with TG in normolipidemic samples, including APOA5, TRIB1, TBL2, GCKR, GALNT2 and ANGPTL3 were significantly associated with HLP types 2B, 3, 4 and 5. PMID: 19656773

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.
  • 蛋白家族:
    Glycosyltransferase 2 family, GalNAc-T subfamily
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 4124

    OMIM: 602274

    KEGG: hsa:2590

    STRING: 9606.ENSP00000355632

    UniGene: Hs.743964



主站蜘蛛池模板: 阳茎伸入女人阳道视频| 天天躁日日躁狠狠躁欧美老妇小说 | 69堂人成无码免费视频果冻传媒| av性色av久久无码ai换脸| 国产精品久久久久9999高清| 日韩一区二区三区无码影院| 亚洲国产一区二区三区在观看| 日本高清不卡aⅴ免费网站| 亚洲丁香婷婷久久一区二区| 髙清国产性猛交xxxand| 国产揉捏爆乳巨胸挤奶视频| 无码一区二区三区av免费蜜桃| 丰满熟妇乱子伦| 亚洲精华国产精华精华液网站| 精品国产一区av天美传媒| 香蕉噜噜噜噜私人影院| 国产一区二区亚洲精品| 一道本在线伊人蕉无码| 少妇人妻偷人精品一区二区| 亚洲综合一区二区三区四区五区 | 超碰香蕉人人网99精品| 欧洲熟妇色xxxxx欧美| 国产真实伦在线观看| 亚洲成av人在线视| 狼人亚洲国内精品自在线| 强行征服邻居人妻淑敏| 欧美丰满少妇xxxxx| 精品无人乱码一区二区三区的特点| 国产粉嫩嫩00在线正在播放| 日韩亚洲国产中文永久| 欧美影院成年免费版| 中文字幕乱码一区av久久不卡| 亚洲性色成人av| 手机看片久久国产免费| 三男一女吃奶添下面视频| 人妻少妇乱子伦无码专区| 亚洲国产精品无码中文字| 久久婷婷香蕉热狠狠综合| 欧美大片va欧美在线播放| 国产精品无码久久综合网| 国产精品久久久久久福利|