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  4. GALE Antibody

GALE Antibody

  • 中文名稱：
    GALE兔多克隆抗體
  • 貨號：
    CSB-PA613499HA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: GALE antibody at 2µg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: Hela whole cell lysate
      Lane 3: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 39, 31 kDa
      Observed band size: 39 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA613499HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA613499HA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA613499HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GALE Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GALE
  • 別名：
    FLJ95174 antibody; FLJ97302 antibody; Galactose 4 epimerase UDP antibody; Galactowaldenase antibody; galE antibody; GALE_HUMAN antibody; OTTHUMP00000002991 antibody; OTTHUMP00000002994 antibody; OTTHUMP00000037931 antibody; OTTHUMP00000044857 antibody; SDR1E1 antibody; short chain dehydrogenase/reductase family 1E member 1 antibody; UDP galactose 4 epimerase antibody; UDP galactose 4' epimerase antibody; UDP glucose 4 epimerase antibody; UDP-galactose 4-epimerase antibody; UDP-glucose 4-epimerase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human UDP-glucose 4-epimerase protein (1-348AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，GALE Antibody (CSB-PA613499HA01HU)，的標記方式是Non-conjugated。對于GALE Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA613499HB01HU GALE Antibody, HRP conjugated ELISA
    FITC CSB-PA613499HC01HU GALE Antibody, FITC conjugated
    Biotin CSB-PA613499HD01HU GALE Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
  • 基因功能參考文獻：
    1. Mutation in UDP-galactose-4'-epimerase gene is associated with UDP-galactose-4'-epimerase deficiency. PMID: 26565537
    2. Data show the protein structure of GALE and its substrate binding and specificity. It is mutated in type III galactosemia. [review] PMID: 26162744
    3. human UDP-galactose 4'-epimerase stability is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding PMID: 25150110
    4. These data indicated a critical role of GALE in maintaining cartilage homeostasis, and suggested that GALE inhibition might contribute to OA progress. PMID: 25201731
    5. GALE variants can be arranged into three groups depending on the severity of enzyme impairment. PMID: 23644136
    6. P.K161N-hGALE causes its effects by abolishing an important interaction between the protein and the cofactor. PMID: 22613355
    7. study of hGALE crystal structure and demonstration that residue 307 acts as a gatekeeper mediating substrate access to the hGALE active site PMID: 15175331
    8. Resulst describe the relationship among UDP-galactose 4'-epimerase activity, substrate specificity, metabolic balance, and galactose sensitivity in mammalian cells. PMID: 15701638
    9. Data suggest that reduced catalytic efficiency and increased proteolytic susceptibility of UDP-galactose 4-epimerase are causative factors in type III galactosemia. PMID: 16302980
    10. Subtle biochemical and metabolic abnormalities detected in patients expressing these GALE alleles likely reflect, at least in part, the reduced enzymatic activity of the encoded GALE proteins. PMID: 18188677
    11. Our observations show that altered protein stability is due to misfolding and that loss or reduction of enzyme activity is responsible for the molecular defects underlying GALE-deficiency galactosemia. PMID: 19250319
    12. Disease-causing mutations result in a variety of changes to the steady-state parameters. Mostly these are changes in turnover number, kcat. The ability to dimerize is not affected, but some mutants have increased sensitivity to protease digestion. PMID: 16302980

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  • 相關疾病：
    Epimerase-deficiency galactosemia (EDG)
  • 蛋白家族：
    NAD(P)-dependent epimerase/dehydratase family
  • 數據庫鏈接：

    HGNC: 4116

    OMIM: 230350

    KEGG: hsa:2582

    STRING: 9606.ENSP00000363621

    UniGene: Hs.632380



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