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  4. GABRD Antibody

GABRD Antibody

  • 中文名稱：
    GABRD兔多克隆抗體
  • 貨號：
    CSB-PA008564
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    GABRD
  • 別名：
    GABA(A) receptor subunit delta antibody; Gabrd antibody; Gamma aminobutyric acid GABA A receptor delta antibody; Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor antibody; Gamma-aminobutyric acid receptor subunit delta antibody; GBRD_HUMAN antibody; MGC45284 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GABAA Rδ.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 基因功能參考文獻：
    1. This study found that increased methylation of the promoter of the delta subunit GABAA receptor was associated with reduced mRNA and protein levels in the cerebellum of alcohol use disorder subjects. PMID: 29020412
    2. Genome-wide association studies identify GABRD mutation releated to juvenile myoclonic epilepsy PMID: 23756480
    3. In recombinant human cDNA experiments in HEK293 cells, delta subunit coexpression leads to receptors activated by nanomolar THIP concentrations. PMID: 21795619
    4. These findings point to the GABRD gene as a susceptibility gene for COMD. PMID: 20561060
  • 相關疾病：
    Generalized epilepsy with febrile seizures plus 5 (GEFS+5); Epilepsy, idiopathic generalized 10 (EIG10); Juvenile myoclonic epilepsy 7 (EJM7)
  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRD sub-subfamily
  • 數據庫鏈接：

    HGNC: 4084

    OMIM: 137163

    KEGG: hsa:2563

    STRING: 9606.ENSP00000367848

    UniGene: Hs.113882



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