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  4. GABPB1 Antibody

GABPB1 Antibody

  • 中文名稱：
    GABPB1兔多克隆抗體
  • 貨號：
    CSB-PA638451DSR2HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: GABPB1antibody at 1.11μg/ml
      Lane 1: Rat gonadal tissue
      Lane 2: Hela whole cell lysate
      Lane 3: HT29 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 43, 42, 39, 37 kDa
      Observed band size: 43 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA638451DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA638451DSR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GABPB1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GABPB1
  • 別名：
    BABPB2 antibody; E4TF1 antibody; E4TF1-47 antibody; E4TF1-53 antibody; E4TF1B antibody; GA binding protein transcription factor beta subunit 1 transcript variant gamma 2 antibody; GA binding protein transcription factor, beta subunit 1 antibody; GA binding protein transcription factor, beta subunit 2 antibody; GA-binding protein subunit beta-1 antibody; GABP subunit beta-1 antibody; GABP subunit beta-2 antibody; GABP1_HUMAN antibody; GABPB antibody; GABPB-1 antibody; GABPB-2 antibody; GABPB1 antibody; GABPB2 antibody; NRF2B1 antibody; NRF2B2 antibody; Nuclear respiratory factor 2 antibody; Transcription factor E4TF1-47 antibody; Transcription factor E4TF1-53 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human GA-binding protein subunit beta-1 protein (231-395AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcription factor capable of interacting with purine rich repeats (GA repeats). Acts as a a master regulator of nuclear-encoded mitochondrial genes.; (Microbial infection) Necessary for the expression of the Adenovirus E4 gene.
  • 基因功能參考文獻：
    1. Data revealed high expression of GABPB1 in clear cell renal cell carcinoma (ccRCC) tissues and cell lines. Its knockdown significantly decreased the colony formation ability via induction of p21Waf/Cip1 expression. Furthermore, the patients at high risk of a poor survival outcome exhibited the highest expression level of GABPB1. These findings imply that GABPB1 serves an important role in the progression of ccRCC. PMID: 29845229
    2. Ectopic overexpression of a dominant-negative acting GABP mutant led to impaired myeloid differentiation of CD34(+) hematopoietic stem/progenitor cells. PMID: 27100840
    3. role for GABPA/B1 as the critical ETS transcription factors deregulating SDHD expression in the context of highly recurrent promoter mutations in melanoma. PMID: 28108517
    4. GABP beta is required for YAP expression in vitro and in vivo, and that YAP is an important effector downstream of GABP for cell survival and cell-cycle progression. PMID: 23684612
    5. The NRF-2beta nuclear localization signal (NLS) is an unusual but is, nevertheless, a bona fide monopartite-type NLS. PMID: 23856623
    6. NRF-1 and GABP expression is coordinated by NRF-1's activation of the GABPbeta promoter PMID: 21609478
    7. Data show that BRAF knockdown led to suppression of the expression of the GABPbeta, which involved in regulating HPR1 promoter activity. PMID: 21076620
    8. Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency. PMID: 12016589
    9. Results point out that brain-specific angiogenesis inhibitor 2 controls VEGF transcription through GA-binding protein under normal conditions and cerebral ischemia [GA-binding protein gamma]. PMID: 16412436
    10. serum-responsive GABP binding to Ets-binding sites activates the KIS promoter, leading to KIS gene expression, cell migration, and cell cycle progression PMID: 17726090
    11. The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1.[NRF-2beta] PMID: 18343819
    12. The cyrstal structure of a ternary complex containing the mouse GA binding protein transcription factor, beta subunit 2, was resolved at 2.15 angstrom resolution. PMID: 9461436

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  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    HGNC: 4074

    OMIM: 600610

    KEGG: hsa:2553

    STRING: 9606.ENSP00000220429

    UniGene: Hs.654350



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