在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FZD8 Antibody, HRP conjugated

FZD8 Antibody, HRP conjugated

  • 中文名稱：
    FZD8兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA880970LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FZD8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FZD8; Frizzled-8; Fz-8; hFz8
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Frizzled-8 protein (55-233AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
  • 基因功能參考文獻：
    1. FZD8 forms a TGF-beta-regulated complex with TGF-beta receptors that is mediated by the extracellular domains of FZD8 and TGFBR1 PMID: 29717114
    2. In OS tissues, miR-520b was inversely correlated with FZD8 expression. FZD8 was upregulated in human spinal OS tissues and cell lines. PMID: 28247840
    3. miR-375 functions as a tumor-suppressive microRNA by directly acting upon FZD8, which may serve as a new therapeutic target to inhibit tumor metastasis in colorectal cancer PMID: 27276676
    4. Elevated expression of TP53 target FZD8 promoted prostate cancer bone metastasis by activating the canonical Wnt/beta-catenin signaling pathway. PMID: 28602974
    5. these findings suggest that miR-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/b-catenin signaling pathway and manipulation of miR-100 may provide a promoting therapeutic strategy for cancer breast treatment. PMID: 26537584
    6. Frizzled-8 has an important pro-inflammatory role and suggest that its expression is related to chronic bronchitis. PMID: 26797711
    7. report the discovery of a human-accelerated regulatory enhancer (HARE5) of FZD8, a receptor of the Wnt pathway implicated in brain development and size PMID: 25702574
    8. Study concludes that expression of Fzd8 is repressed in multiple cancers and suggest it may have a role as a tumor suppressor. PMID: 26590425
    9. c-Met upregulated FZD8 through the ERK/c-Fos cascade in HN-CSC. Taken together, our results offer a preclinical proof-of-concept for targeting the c-Met/FZD8 signaling axis as a CSC-directed therapy to improve HNSCC treatment PMID: 25320014
    10. These observations suggest that c-Jun is involved in APF-mediated inhibition for bladder tumor cell growth PMID: 21872498
    11. APF has been shown to be a nine-residue frizzled-8 protein-related sialoglycopeptide. Subsequent research has gradually clarified the molecular mechanisms underlying the profound antiproliferative effect of APF. PMID: 22738385
    12. analysis of the frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6 PMID: 20093360
    13. molecular model of the Wnt protein binding site on the surface of dimeric CRD domain of the Fzd8 receptor PMID: 18505162

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor Fz/Smo family
  • 組織特異性：
    Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 4046

    OMIM: 606146

    KEGG: hsa:8325

    STRING: 9606.ENSP00000363826

    UniGene: Hs.302634



主站蜘蛛池模板： 欧美日本特级婬片视频| 网禁拗女稀缺资源在线观看| 欧美熟妇性xxxx交潮喷| 国内午夜熟妇又乱又伦| 精品久久综合1区2区3区激情| 精品久久人人爽天天玩人人妻 | 中文字幕乱码中文乱码51精品| 无码人妻丰满熟妇区毛片| 亚州中文字幕无码中文字幕| 久欠精品国国产99国产精2021| 在线天堂资源www| 亚洲国产成人无码av在线| 在线播放亚洲第一字幕| 国产精品多p对白交换绿帽| 中文天堂在线资源www| 宅男色影视亚洲人在线| 亚洲欧美综合在线天堂| 日韩成人极品在线内射3p蜜臀| 香蕉伊蕉伊中文视频在线| 中国人妻被两个老外三p| 伊人久久大香线蕉av五月天| 国产95在线 | 亚洲| 国产欧美精品aaaaaa片| 99热这里只就有精品22| 影音先锋日日狠狠久久| 中文字幕制服丝袜人妻动态图 | 亚洲和欧洲一码二码区别7777| 少妇乳大丰满在线播放| www婷婷av久久久影片| 99久久免费精品高清特色大片| 成年女人午夜毛片免费视频| 亚洲综合色在线观看一区| 色婷婷av一区二区三区浪潮| 99热这里只有精品免费播放| 自慰小少妇毛又多又黑流白浆| 亚洲精品成人老司机影视| 婷婷丁香五月亚洲中文字幕| 日出水了特别黄的视频| 成人伊人亚洲人综合网站| 大伊香蕉在线精品视频75| 乌克兰少妇xxxx做受野外|