在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FUT8 Antibody

  • 中文名稱:
    FUT8兔多克隆抗體
  • 貨號(hào):
    CSB-PA009082GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    6-fucosyltransferase antibody; Alpha (1,6) fucosyltransferase antibody; Alpha-(1,6)-fucosyltransferase antibody; Alpha1 6FucT antibody; alpha1-6FucT antibody; Fucosyltransferase 8 (alpha (1,6) fucosyltransferase) antibody; Fucosyltransferase 8 antibody; FUT8 antibody; FUT8_HUMAN antibody; GDP fucose glycoprotein fucosyltransferase antibody; GDP L Fuc:N acetyl beta D glucosaminide alpha1,6 fucosyltransferase antibody; GDP-fucose--glycoprotein fucosyltransferase antibody; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1 antibody; Glycoprotein 6 alpha L fucosyltransferase antibody; Glycoprotein 6-alpha-L-fucosyltransferase antibody; MGC26465 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human FUT8
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
  • 基因功能參考文獻(xiàn):
    1. loss of function mutations in FUT8 cause a congenital disorder of glycosylation (FUT8-CDG) characterized by defective core fucosylation. PMID: 29304374
    2. we also demonstrated that overexpression of FUT8 might be responsible for the decreased PSA expression in prostate cancer specimens. To our knowledge, this is the first study reporting the functional role of fucosylated enzyme in the development of castration-resistant prostate cancer. PMID: 29339807
    3. This study thus provides insights into the interplay among FUT8, N-acetylglucosaminyltransferase , and GnT-V in N-linked glycosylation during the assembly of glycoproteins. PMID: 28678517
    4. Our results reveal a positive feedback mechanism of FUT8-mediated receptor core fucosylation that promotes TGF-b signaling and EMT, thus stimulating breast cancer cell invasion and metastasis. PMID: 28982386
    5. FUT8 is regulated by microRNAs and has a role in hepatocellular carcinoma progression PMID: 27533464
    6. We observed a strong correlation between EVI1 and alpha1, 6-fucosyltransferase (FUT8) in the chronic phase of the disease and both of them were found to be up-regulated with the progression of the disease. PMID: 27967290
    7. This study demonstrated that the alteration of FTU8 expression in the superior temporal gyrus of elderly patients with schizophrenia. PMID: 27773385
    8. results suggest that an appropriate polypeptide context or other adequate structural elements in the acceptor substrate could facilitate the core fucosylation by FUT8 PMID: 28729420
    9. FUT8 is a driver of melanoma metastasis which, when silenced, suppresses invasion and tumor dissemination. PMID: 28609658
    10. The production of the homogeneous core-fucosylated Man5GlcNAc2 glycoform of EPO in the FUT8-overexpressed HEK293S GnT I(-/-) cell line represents the first example of production of fully core-fucosylated high-mannose glycoforms. PMID: 27008861
    11. Expression of FUT8 can stratify breast cancer tissue and may be considered a prognostic marker for breast cancer patients PMID: 26596733
    12. MiR-198 was shown to target the 3'UTR of FUT8 directly to downregulate FUT8 expression. PMID: 25174450
    13. High expression of FUT8 is associated with an unfavorable clinical outcome in patients with potentially curatively resected NSCLCs, suggesting that FUT8 can be a prognostic factor. PMID: 25572677
    14. Our results suggest that FUT8 may be associated with aggressive PCa and thus is potentially useful for its prognosis. PMID: 24906821
    15. miR-122 and miR-34a are able to target FUT8 3'UTR PMID: 24130780
    16. alpha 1,6-fucosyltransferase 8 expression might be a good indicator of poor prognosis in hepatocellular carcinoma. High alpha 1,6-fucosyltransferase 8 expression may play an important role in hepatitis B virus-related hepatocellular carcinoma progression PMID: 23352314
    17. findings define FUT8 as a novel factor for hemoglobin production and demonstrate that core fucosylation plays an important role in erythroid differentiation PMID: 23609441
    18. The FUT8 gene Thr267Lys polymorphism is associated with human pulmonary emphysema (PE). PMID: 22011814
    19. in colorectal carcinoma patients with moderate or strong alpha(1,6)fucosyltransferase expression, a significant decrease in the overall (P = .04) and disease-free (P = .03) survival rates was observed PMID: 21652057
    20. Expression of FUT8 is regulated by three different promoters, starting transcription in exons A, B, or C. PMID: 14514715
    21. These results suggest that FUT8 expression may be a key factor in the progression of thyroid papillary carcinomas, but not follicular carcinomas, and decreases in FUT8 expression might be linked to anaplastic transformation. PMID: 14568171
    22. We investigated mRNA levels of glycosyltransferases, namely N-acetylglucosaminyltransferase a (GnT)-IVb, and found that (GnT)-IVb expression was increased in HLE-cells resistant to Epirubicin PMID: 17488527
    23. Vascular endothelial growth factor receptor-2 (VEGFR-2) expression was significantly suppressed in Fut8(-/-) mice, suggesting that Fut8 was required for VEGFR-2 expression. PMID: 19179362

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Glycosyltransferase 23 family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 4019

    OMIM: 602589

    KEGG: hsa:2530

    STRING: 9606.ENSP00000353910

    UniGene: Hs.597649



主站蜘蛛池模板: 美女露全乳无遮掩视频| 大ji巴好深好爽又大又粗视频| 久久精品日韩av无码| 熟女人妻视频| 国产精品福利自产拍在线观看| 国产精品久人妻精品| 亚洲精品午夜理伦不卡在线观看| 夜色爽爽影院18禁妓女影院| 国产av人人夜夜澡人人爽麻豆| 97超级碰碰人妻中文字幕| 日韩在线一区二区不卡视频| 久久婷婷狠狠综合激情| 极品少妇一区二区三区四区| 国产亚洲美女精品久久久2020| 国产又黄又猛又粗又爽的a片动漫| 成人性生交大片免费看vr| 久久精品国产亚洲欧美成人| 国产精品午夜剧场免费观看| 人妻无码人妻有码中文字幕| 国产69精品久久久久app下载| 国产av亚洲aⅴ一区二区| av无码欧洲亚洲电影网| 亂倫近親相姦中文字幕| 四虎成人精品在永久在线| 免费无码成人av片在线| 玩弄丰满少妇xxxxx性多毛| 18禁裸体女免费观看| 国产精品视频一区二区三区无码| 国产成人愉拍免费视频| 天美麻花果冻视频大全英文版| 色播亚洲视频在线观看| 国产成人亚洲综合图区| 欧美群妇大交群| 国产中文字幕乱人伦在线观看| 国产在线精品视频二区| 亚洲精品久久久久一区二区三区| 老妇女性较大毛片| 狠狠cao2020高清视频| 午夜成人亚洲理论片在线观看| 女人另类牲交zozozo| 香港三级韩国三级日本三级 |