在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FUT3 Antibody, HRP conjugated

FUT3 Antibody, HRP conjugated

  • 中文名稱：
    FUT3兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA009077LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FUT3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FUT3; FT3B; LE; 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3; Alpha-3-fucosyltransferase FUT3; Blood group Lewis alpha-4-fucosyltransferase; Lewis FT; Fucosyltransferase 3; Fucosyltransferase III; FucT-III
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Galactoside 3(4)-L-fucosyltransferase protein (83-187AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens. Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration. Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin. Prefers type 1 chain over type 2 acceptors. Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred. Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme.
  • 基因功能參考文獻(xiàn)：
    1. High FUT3 expression is associated with breast cancer. PMID: 26908442
    2. the high expressions of BCL6 and Lewis y antigen are associated with development, high tumor burden, and worse prognosis of ovarian cancer and targeting BCL6 could be a novel therapeutic strategy for ovarian cancer treatment. PMID: 28671040
    3. the miRNA expression vector which targets the FUT3 gene can effectively inhibit the proliferation, migration and invasion abilities of KATO-III cells. PMID: 27453266
    4. Polymorphisms in FUT3 and its intestinal expression might be associated with ulcerative colitis pathogenesis. PMID: 26766790
    5. Data suggest that fucosyltransferase 3 (FUT3) gene rs28362459 and rs3745635 single nucleotide polymorphisms (SNPs) may engender the increased risk of ileocolonic and ileal Crohn's disease (CD). PMID: 26663064
    6. that the absence of alpha1,3/4-fucosyltransferase enzyme is related to breast's invasive breast carcinoma PMID: 26321244
    7. Mutations of FUT3 (rs28362459) and (rs3745635) might influence the lesion locations in CD patients. PMID: 24720527
    8. Obtained FST values reveal distinct frequencies of the FUT3 SNPs between the present sample and its representative ancestral populations. PMID: 23922852
    9. down-regulation of FUT3 and FUT5 reduces the expression of sialyl-Lewis antigens and the adhesion capacities of gastric cancer cells and allows to identify the specific alpha1-3,4 fucosyltransferases implicated in the Lewis antigens synthesis PMID: 21978830
    10. Elevated expression of Topo-I and Topo-II beta is found in Lewis(y) antigen-overexpressing ovarian cancer cells. PMID: 21542140
    11. LeY is carried by integrin alphavbeta3 and plays a critical role in attachment to cultured cells. LeY activates integrin alphavbeta3/focal adhesion kinase (FAK) signaling. PMID: 20605574
    12. At physiological levels of wall shear stress, the number of flowing cancer cells recruited to the microtube surface was dramatically reduced by FUT3 knockdown PMID: 20833389
    13. Lewis-negative genotype was associated with invasive ductal breast carcinoma but not with anatomoclinical parameters PMID: 20514537
    14. GALNT14 and FUT3/6 H-scores were significantly higher in non-small cell lung cancer cell lines sensitive to dulanermin and drozitumab versus resistant cell lines PMID: 20179215
    15. Increased expression of Lewis y antigen plays an important role in promoting cell proliferation through activating PI3K/Akt signaling pathway in ovarian carcinoma-derived RMG-I cells. PMID: 20003467
    16. PCR using sequence-specific primers DNA enables efficient genotyping of clinical samples PMID: 11668626
    17. Sialy Lewis-X antigens play an important role liver metastases of colon carcinoma. PMID: 11819805
    18. Distribution of Lewis (FUT3)genotype and allele frequencies by ethnicity in a United States population. PMID: 12424536
    19. Cys, Gln, and Tyr residues are important for FT3wt sorting into the transport vesicles possibly due to interactions with other membrane proteins PMID: 12493760
    20. study of the Lewis gene polymorphisms in a Caucasian Portuguese population with a high rate of H. pylori infection, and evaluation of the implications of mutant enzymes in Le(b) expression in the gastric mucosa PMID: 12730721
    21. results indicated that Mn2+ bound the enzyme and increased its affinity for the acceptor PMID: 14977360
    22. The heterologous enzyme hFUT3 was strongly expressed and fully functional in transgenic tobacco, which showed a delay in growth linked to a reduction of internode length. PMID: 15331092
    23. cloning and characterization of the promoter; strong correlation between the promoter activity and high expression of sialyl Le(a) observed in colon carcinoma cell lines seem to confirm the important regulatory role of FUT3 in synthesis of sialyl Le(a) PMID: 16199102
    24. LeX motif present in human milk can bind to dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), thereby preventing the capture and subsequent transfer of HIV-1 to CD4+ T lymphocytes. PMID: 16239964
    25. T3 overexpression in gastric cells depends upon promoter hypomethylation and FUT3 is responsible for overexpression of Le(a) in gastric cells, in vitro PMID: 16427187
    26. functional mutations of the FUT3 gene may be associated with an increased atherothrombotic disease prevalence, especially among abstainers PMID: 17383304
    27. increased CD15 expression is not due to de novo biosynthesis of CD15, but results predominantly from induction of alpha(2-3)-sialidase activity PMID: 18953356
    28. Expression of sLex antigen in breast cancer is not associated with breast cancer survival. PMID: 18977761
    29. These findings indicate that Lewis y antigen have the ability to enhance the proliferation and elevate the survival rates of RMG-I cells, which can promote the genesis and development of ovarian carcinoma PMID: 19137814
    30. Sequence analysis of FUT3 identified many SNPs, but most of them are in complete linkage disequilibrium with previously reported SNPs responsible for the Lewis-negative phenotype. PMID: 19175549
    31. results suggested that PKR is the primary target for HSV-1 early RNA during induction of FUT3, FUT5, and FUT6 PMID: 19349624
    32. in breast cancer there was a limited humoral immune response through Lewis y/IgM/CIC levels detection which correlated with MUC1/IgM/CIC PMID: 19715603

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
  • 蛋白家族：
    Glycosyltransferase 10 family
  • 組織特異性：
    Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4014

    OMIM: 111100

    KEGG: hsa:2525

    STRING: 9606.ENSP00000305603

    UniGene: Hs.169238



主站蜘蛛池模板： 国产亚洲精品久久久久久大师| 国产在线精品一区二区中文| 久久久久成人精品免费播放动漫 | 欧美嫩交一区二区三区| awww在线天堂bd资源在线| 亚洲精品一区二三区不卡| 国产女主播白浆在线观看| 国产在线精品无码不卡手机免费 | 丰满人妻被公侵犯高清版| 欲香欲色天天综合久久| 亚洲熟妇无码av不卡在线播放| 成人天堂资源www在线| 国产精品久久久国产盗摄| 久久人人97超碰超国产| 久久久无码精品亚洲日韩啪啪网站| 久久久99精品免费观看| 亚洲一本大道av久在线播放| 四十如虎的丰满熟妇啪啪| 免费无码国产欧美久久18| 国产精品美女久久久久久久| 天堂资源中文最新版在线一区 | 久久精品99国产国产精| 成人精品一区二区三区电影免费| 性无码专区一色吊丝中文字幕| 国产女人高潮毛片| 先锋影音最新色资源站| 久久久青草青草免费看| 国产成人8x人网站在线视频| 国产精品久久久久久久久电影网 | 97热久久免费频精品99| 久久午夜神器| 麻豆av一区二区三区久久| 99久久免费国产精品四虎| 久久久精品456亚洲影院| 国产精品美女久久久久av爽| 国产乱子伦视频一区二区三区| 最新版天堂资源中文官网| 无码乱肉视频免费大全合集| 天躁夜夜躁狼狠躁| 亚洲人成伊人成综合网中文| 久久国产精品老女人|