在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FUCA1 Antibody, HRP conjugated

  • 中文名稱:
    FUCA1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA009062LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FUCA1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Alpha L fucosidase I antibody; Alpha L fucoside fucohydrolase antibody; Alpha-L-fucosidase 1 antibody; Alpha-L-fucosidase I antibody; Alpha-L-fucoside fucohydrolase 1 antibody; FUCA antibody; FUCA1 antibody; FUCO_HUMAN antibody; fucosidase; alpha-L; tissue antibody; fucosidase; alpha-L- 1; tissue antibody; Tissue alpha L fucosidase antibody; Tissue alpha-L-fucosidase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Tissue alpha-L-fucosidase protein (32-158AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
  • 基因功能參考文獻:
    1. Homozygous frameshift mutation in the FUCA1 gene causes both severe and mild fucosidosis. PMID: 29588375
    2. alterations in plasma levels of FUCA-1 were significantly associated with chronic inflammatory and autoimmune disorders, both in children and adults PMID: 28808940
    3. the down-regulation of FUCA-1 correlates with increased aggressiveness of the cancer type. This is the first report indicating that the down-regulation of FUCA-1 is related to the increased aggressiveness of thyroid cancer. PMID: 28404918
    4. the possibility that the higher fucose levels on cell surface glycans of aggressive anaplastic thyroid cancer samples (ATCs), compared to those of less aggressive papillary thyroid cancer samples(PTC), may be at least in part responsible for the more aggressive and metastatic phenotype of ATCs compared to PTCs, as the expression levels of FUCA1 and FUT8 were inversely related in these two types of cancers. PMID: 28440416
    5. RNAi-mediated knockdown of endogenous FUCA1 significantly attenuates p53-dependent, chemotherapy-induced apoptotic death. PMID: 27315169
    6. whole exome sequencing and array-based comparative genomic hybridization analysis revealed that the patient was compound heterozygous for a single base-pair deletion inherited from his father, and a 3281-base-pair deletion covering exon 3 inherited from his mother. Neither mutation has been reported before so the FUCA1 mutational spectrum is herein expanded. PMID: 27706744
    7. results show that protein defucosylation mediated by FUCA1 is involved in tumor suppression PMID: 26998741
    8. FUCA1 downregulation confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface PMID: 26204487
    9. We observed significant lower values of GAL, alpha-fucosidase and tendency to decrease of MAN and GLU concentration in nasal polyps PMID: 23911047
    10. Serum alpha-L-fucosidase levels were significantly elevated in hepatocellular carcinoma. PMID: 25129443
    11. IL-13, IL-4 and IL-5 have no effect on the expression of FUCA1 and FUCA2, but its expression is upregulated by IFN-gamma, a Th1 cytokine. PMID: 24469468
    12. Preoperative serum AFU is a prognostic predictor of hepatocellular carcinoma. PMID: 24569461
    13. Diminished FUCA1 mRNA levels in tumors, indicate that expression of tissue alpha-L-fucosidase could be regulated at transcriptional level in colorectal cancer. PMID: 23965968
    14. In the serum of patients with Lyme disease, GAL activity significantly increased (p = 0.029), and the activity of FUC had a tendency to increase (p = 0.153), compared to the control group. PMID: 22763966
    15. Data show that the correlation between the fluorescence activity of the enzyme AFU by the developed procedures and the standard method was positive and highly significant in patients and controls. PMID: 19782187
    16. The purified alpha-L-fucosidase from primary hepatocarcinoma (PHC) is different in its properties from alpha-L-fucosidase in human other organs. The polyclonal antibody prepared in this experiment can be applied to the diagnosis of PHC. PMID: 16773698
    17. The fucosidase has a role in the intimate species signature interactions between sperm and oocyte. PMID: 17133604
    18. following HIV infection, there is an increased rate of catabolism of glycoconjugates in saliva resulting from changes in the proportions of the activity of isoenzymes A and B of N-acetyl-beta-hexosaminidase, beta-galactosidase and alpha-fucosidase PMID: 18217416

    顯示更多

    收起更多

  • 相關疾病:
    Fucosidosis (FUCA1D)
  • 亞細胞定位:
    Lysosome.
  • 蛋白家族:
    Glycosyl hydrolase 29 family
  • 數據庫鏈接:

    HGNC: 4006

    OMIM: 230000

    KEGG: hsa:2517

    STRING: 9606.ENSP00000363603

    UniGene: Hs.370858



主站蜘蛛池模板: 4hu四虎永久在线影院| 亚洲国产成人片在线观看无码| 国产精品老汉av| 日韩国产精品人妻无码久久久| 纯爱无遮挡h肉动漫在线播放| 久久久精品午夜免费不卡| 亚洲一区二区三区无码久久| 日本真人边吃奶边做爽动态图| 国产乱子伦60女人的皮视频| 亚洲中文字幕无码中字| 成人h动漫精品一区二区| 国内精品乱码卡一卡2卡麻豆| 国产午夜福利伦理300| 绝顶丰满少妇av无码| 欧美zozo另类特级| 国产 日韩 欧美 视频 制服| 久久精品国产网红主播| 精品免费久久久久久久| 午夜精品电影你懂的| 国产精品高潮呻吟av久久黄| 免费人成激情视频在线观看冫| 新狼窝色av性久久久久久| 精品国产丝袜自在线拍国语| 日本丰满护士videossexhd| 996热re视频精品视频这里| 边吃奶边添下面好爽| 四虎国产精亚洲一区久久特色| 精品精品国产理论在线观看| 久久久久高潮综合影院| 国产麻豆剧果冻传媒一区| 亚洲视频无码高清在线| 亚洲精品gv天堂无码男同 | 丰满岳乱妇在线观看中字无码 | 一个色综合国产色综合| 日韩精品无码去免费专区| 久久国产精品波多野结衣av| 亚洲福利国产网曝| 国内精品久久久久影院优| 99精品欧美一区二区三区| 日日躁夜夜躁狠狠躁| 国产精品爽爽ⅴa在线观看|