在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FRS2 Antibody

  • 中文名稱:
    FRS2兔多克隆抗體
  • 貨號:
    CSB-PA009004GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    FGFR signaling adaptor SNT antibody; FGFR signalling adaptor antibody; FGFR substrate 2 antibody; FGFR-signaling adaptor SNT antibody; Fibroblast growth factor receptor substrate 2 antibody; FRS 2 antibody; FRS2 antibody; FRS2_HUMAN antibody; FRS2A antibody; FRS2alpha antibody; SNT 1 antibody; SNT antibody; SNT-1 antibody; SNT1 antibody; Suc 1 Associated Neurotrophic Factor Target antibody; Suc1 associated neurotrophic factor target 1 antibody; Suc1-associated neurotrophic factor target 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human FRS2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
  • 基因功能參考文獻:
    1. loss of myristoylation of fibroblast growth factor receptor substrate 2 (FRS2alpha), a scaffold protein essential for FGFR signaling, inhibits FGF/FGFR-mediated oncogenic signaling and FGF10-induced tumorigenesis. Moreover, a previously synthesized myristoyl-CoA analog, B13, which targets the activity of N-myristoyltransferases. PMID: 29540482
    2. These findings suggest that FRS2 is amplified consistently in liposarcoma. PMID: 29368794
    3. MiR-4653-3p and its target gene FRS2 are may have roles in response of hormone receptor positive breast cancer patients to tamoxifen PMID: 27533459
    4. we report for the first time that PKD1 was tightly regulated by androgen at the transcriptional level in prostate cancer cells and was a novel androgen-repressed gene. Further analysis identified FRS2 as a novel mediator of androgen-induced PKD1 repression. PMID: 28077787
    5. They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies. PMID: 26096936
    6. Results identify FRS2 as an oncogene in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications. PMID: 25368431
    7. Increased expression of FRS2alpha (and FGFR1) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma treated with sorafenib. PMID: 25900027
    8. The signaling complex appears to integrate the input from FGFR and EphA4, and release the output signal through FRS2alpha. PMID: 20184660
    9. These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development. PMID: 24284065
    10. The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling. PMID: 24706887
    11. Patient with pigmentation disorders and vitiligo show decreased expression of mRNA. PMID: 22151832
    12. Data indicate that the FGFR/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas. PMID: 23393200
    13. Validated FRS2 amplification in both Well-differentiated liposarcoma and dedifferentiated liposarcoma. PMID: 21793095
    14. Microdeformations produced by the combination of polyurethane foam and suction are associated with increased fibroblast proliferation and up-regulation of gene expressions in fibroblasts PMID: 21233699
    15. Phosphorylation of Fibroblast growth factor receptor substrate 2alpha may function as a molecular switch in the FGF pathway, sensing and participating in crosstalk with other signaling pathways. PMID: 19652666
    16. FRS2 has a role in fibroblast growth factor-2-induced signaling PMID: 12571252
    17. findings support a broader role of FRS2 in EGFR-controlled signaling pathways in A-431 cells and provide insight into a molecular mechanism for ligand-stimulated feedback regulation with FRS2 as a central regulatory switch point PMID: 12974390
    18. Bisindolylmaleimide I does not inhibit FGF2-induced tyrosine phosphorylation of Frs2. PMID: 17145761
    19. an important function for FRS2 is to concentrate RET in membrane foci, leading to an engagement of specific signaling complexes localized in these membrane domains PMID: 18189271
    20. a dual mechanism where deletion of the 770YXXL773 motif promotes FGFR2 IIIb C3 transforming activity by causing aberrant receptor recycling and stability and persistent FRS2-dependent signaling. PMID: 19103595
    21. Mechanical wounding induces significant ROS generation at the wound edge which, in turn, induced ligand-independent KGFR and FRS2 activation via c-Src kinase signaling. PMID: 19111446

    顯示更多

    收起更多

  • 亞細胞定位:
    Endomembrane system. Note=Cytoplasmic, membrane-bound.
  • 組織特異性:
    Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
  • 數據庫鏈接:

    HGNC: 16971

    OMIM: 607743

    KEGG: hsa:10818

    STRING: 9606.ENSP00000299293

    UniGene: Hs.593446



主站蜘蛛池模板: 国产午夜福利不卡在线观看| 伦伦影院午夜理论片| 国产熟妇高潮叫床视频播放| 人妻少妇heyzo无码专区| 三级做a全过程在线观看| 成人国产一区二区三区精品不卡| 久久99精品久久久久久不卡| 欧美巨大巨粗黑人性aaaaaa| 亚洲色大成网站www永久网站| 久久超碰97人人做人人爱| 亚洲精品综合一区二区| 欧美丰满熟妇xxxx性ppx人交 | 国产精品三级国产电影| 人人人插人人费| 国产精品久久久久无码av1| av午夜福利一片免费看久久| 美女露出奶头扒开尿口免费网站| 国产精品亚洲欧美大片在线观看| 国产欧美一区二区精品仙草咪| 人妻熟妇乱又伦精品hd| 无码人妻精品一区二区三18禁| 理论片87福利理论电影| 成人午夜亚洲精品无码区毛片| 亚洲五月色丁香婷婷婷| 天天摸夜夜添夜夜无码| 麻花豆传媒剧国产免费mv入口| av无码一区二区二三区1区6区| 国产精品va在线播放| 国产高清在线a视频大全| 国产亚洲情侣一区二区无| 日本十八禁黄无遮禁视频免费 | 久久久久无码精品国产人妻无码 | 国产欧美日韩另类在线专区| 免费无码久久成人网站入口| 国产黑色丝袜在线视频| 国产真人无码作爱视频免费| 老司机免费的精品视频| 国产精品天天狠天天看| 看全色黄大色大片免费久久| 亚洲va在线va天堂xxxx中文| 亚洲 综合 自拍 精品 在线|