在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FRS2 (Ab-196) Antibody

  • 中文名稱:
    FRS2 (Ab-196)兔多克隆抗體
  • 貨號:
    CSB-PA208276
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HepG2 cells, using FRS2 (Ab-196) antibody.
    • Western blot analysis of extracts from 293 cells (Lane 2), using FRS2 (Ab-196) antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FRS2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized non-phosphopeptide derived from Human FRS2 around the phosphorylation site of tyrosine 196 (H-T-Y(p)-V-N).
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
  • 基因功能參考文獻:
    1. loss of myristoylation of fibroblast growth factor receptor substrate 2 (FRS2alpha), a scaffold protein essential for FGFR signaling, inhibits FGF/FGFR-mediated oncogenic signaling and FGF10-induced tumorigenesis. Moreover, a previously synthesized myristoyl-CoA analog, B13, which targets the activity of N-myristoyltransferases. PMID: 29540482
    2. These findings suggest that FRS2 is amplified consistently in liposarcoma. PMID: 29368794
    3. MiR-4653-3p and its target gene FRS2 are may have roles in response of hormone receptor positive breast cancer patients to tamoxifen PMID: 27533459
    4. we report for the first time that PKD1 was tightly regulated by androgen at the transcriptional level in prostate cancer cells and was a novel androgen-repressed gene. Further analysis identified FRS2 as a novel mediator of androgen-induced PKD1 repression. PMID: 28077787
    5. They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies. PMID: 26096936
    6. Results identify FRS2 as an oncogene in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications. PMID: 25368431
    7. Increased expression of FRS2alpha (and FGFR1) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma treated with sorafenib. PMID: 25900027
    8. The signaling complex appears to integrate the input from FGFR and EphA4, and release the output signal through FRS2alpha. PMID: 20184660
    9. These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development. PMID: 24284065
    10. The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling. PMID: 24706887
    11. Patient with pigmentation disorders and vitiligo show decreased expression of mRNA. PMID: 22151832
    12. Data indicate that the FGFR/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas. PMID: 23393200
    13. Validated FRS2 amplification in both Well-differentiated liposarcoma and dedifferentiated liposarcoma. PMID: 21793095
    14. Microdeformations produced by the combination of polyurethane foam and suction are associated with increased fibroblast proliferation and up-regulation of gene expressions in fibroblasts PMID: 21233699
    15. Phosphorylation of Fibroblast growth factor receptor substrate 2alpha may function as a molecular switch in the FGF pathway, sensing and participating in crosstalk with other signaling pathways. PMID: 19652666
    16. FRS2 has a role in fibroblast growth factor-2-induced signaling PMID: 12571252
    17. findings support a broader role of FRS2 in EGFR-controlled signaling pathways in A-431 cells and provide insight into a molecular mechanism for ligand-stimulated feedback regulation with FRS2 as a central regulatory switch point PMID: 12974390
    18. Bisindolylmaleimide I does not inhibit FGF2-induced tyrosine phosphorylation of Frs2. PMID: 17145761
    19. an important function for FRS2 is to concentrate RET in membrane foci, leading to an engagement of specific signaling complexes localized in these membrane domains PMID: 18189271
    20. a dual mechanism where deletion of the 770YXXL773 motif promotes FGFR2 IIIb C3 transforming activity by causing aberrant receptor recycling and stability and persistent FRS2-dependent signaling. PMID: 19103595
    21. Mechanical wounding induces significant ROS generation at the wound edge which, in turn, induced ligand-independent KGFR and FRS2 activation via c-Src kinase signaling. PMID: 19111446

    顯示更多

    收起更多

  • 亞細胞定位:
    Endomembrane system. Note=Cytoplasmic, membrane-bound.
  • 組織特異性:
    Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
  • 數據庫鏈接:

    HGNC: 16971

    OMIM: 607743

    KEGG: hsa:10818

    STRING: 9606.ENSP00000299293

    UniGene: Hs.593446



主站蜘蛛池模板: 最近中文av字幕在线中文| 国产精品成人永久在线| 伊人无码一区二区三区| 亚洲国产精品无码中文lv| 国产乱人伦无无码视频试看| 国产乱妇乱子视频在播放| 欧美xxxx做受欧美1314| 国产成 人 综合 亚洲| 欧美人与牲动交xxxx| 午夜天堂精品久久久久| 成人午夜看黄在线尤物成人| 国产成人av一区二区三区无码| 日韩欧美精品有码在线 | h无码精品3d动漫在线观看| 久久无码专区国产精品| 久久国产色av免费看| 国产午夜精品一区理论片飘花| 国产h视频在线观看| 久久精品av麻豆| 一級特黃色毛片免費看| 青春草在线视频观看| 水蜜桃av无码| 亚洲精品综合一区二区三| 在线 | 国产精品星空传媒丿| 国产免费无码一区二区三区| 亚洲永久网址在线观看| 无码av岛国片在线播放| 人妻精品人妻无码一区二区三区| 精品亚洲成a人在线观看| 亚洲熟妇无码八av在线播放| 日韩爆乳一区二区无码| 青青草原精品资源站久久| 无套内谢老熟女| 亚洲午夜久久久久妓女影院| 综合激情五月综合激情五月激情1| 中文字幕人妻丝袜二区| 国产精品久久久久9999小说| 欧洲一卡2卡3卡4卡国产| 800av凹凸视频在线观看| 国产麻豆成人传媒免费观看| 亚洲综合色在线视频www|