在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FRS2 (Ab-196) Antibody

  • 中文名稱:
    FRS2 (Ab-196)兔多克隆抗體
  • 貨號:
    CSB-PA208276
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HepG2 cells, using FRS2 (Ab-196) antibody.
    • Western blot analysis of extracts from 293 cells (Lane 2), using FRS2 (Ab-196) antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FRS2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized non-phosphopeptide derived from Human FRS2 around the phosphorylation site of tyrosine 196 (H-T-Y(p)-V-N).
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
  • 基因功能參考文獻:
    1. loss of myristoylation of fibroblast growth factor receptor substrate 2 (FRS2alpha), a scaffold protein essential for FGFR signaling, inhibits FGF/FGFR-mediated oncogenic signaling and FGF10-induced tumorigenesis. Moreover, a previously synthesized myristoyl-CoA analog, B13, which targets the activity of N-myristoyltransferases. PMID: 29540482
    2. These findings suggest that FRS2 is amplified consistently in liposarcoma. PMID: 29368794
    3. MiR-4653-3p and its target gene FRS2 are may have roles in response of hormone receptor positive breast cancer patients to tamoxifen PMID: 27533459
    4. we report for the first time that PKD1 was tightly regulated by androgen at the transcriptional level in prostate cancer cells and was a novel androgen-repressed gene. Further analysis identified FRS2 as a novel mediator of androgen-induced PKD1 repression. PMID: 28077787
    5. They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies. PMID: 26096936
    6. Results identify FRS2 as an oncogene in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications. PMID: 25368431
    7. Increased expression of FRS2alpha (and FGFR1) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma treated with sorafenib. PMID: 25900027
    8. The signaling complex appears to integrate the input from FGFR and EphA4, and release the output signal through FRS2alpha. PMID: 20184660
    9. These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development. PMID: 24284065
    10. The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling. PMID: 24706887
    11. Patient with pigmentation disorders and vitiligo show decreased expression of mRNA. PMID: 22151832
    12. Data indicate that the FGFR/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas. PMID: 23393200
    13. Validated FRS2 amplification in both Well-differentiated liposarcoma and dedifferentiated liposarcoma. PMID: 21793095
    14. Microdeformations produced by the combination of polyurethane foam and suction are associated with increased fibroblast proliferation and up-regulation of gene expressions in fibroblasts PMID: 21233699
    15. Phosphorylation of Fibroblast growth factor receptor substrate 2alpha may function as a molecular switch in the FGF pathway, sensing and participating in crosstalk with other signaling pathways. PMID: 19652666
    16. FRS2 has a role in fibroblast growth factor-2-induced signaling PMID: 12571252
    17. findings support a broader role of FRS2 in EGFR-controlled signaling pathways in A-431 cells and provide insight into a molecular mechanism for ligand-stimulated feedback regulation with FRS2 as a central regulatory switch point PMID: 12974390
    18. Bisindolylmaleimide I does not inhibit FGF2-induced tyrosine phosphorylation of Frs2. PMID: 17145761
    19. an important function for FRS2 is to concentrate RET in membrane foci, leading to an engagement of specific signaling complexes localized in these membrane domains PMID: 18189271
    20. a dual mechanism where deletion of the 770YXXL773 motif promotes FGFR2 IIIb C3 transforming activity by causing aberrant receptor recycling and stability and persistent FRS2-dependent signaling. PMID: 19103595
    21. Mechanical wounding induces significant ROS generation at the wound edge which, in turn, induced ligand-independent KGFR and FRS2 activation via c-Src kinase signaling. PMID: 19111446

    顯示更多

    收起更多

  • 亞細胞定位:
    Endomembrane system. Note=Cytoplasmic, membrane-bound.
  • 組織特異性:
    Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
  • 數據庫鏈接:

    HGNC: 16971

    OMIM: 607743

    KEGG: hsa:10818

    STRING: 9606.ENSP00000299293

    UniGene: Hs.593446



主站蜘蛛池模板: 成人国产一区二区三区| 欧美40老熟妇色xxxxx| 极品人妻videosss人妻| 国产免费无遮挡吸奶头视频| 久久亚洲美女精品国产精品| 天堂在/线中文在线资源8| 亚洲精品无码少妇30p| 无码毛片内射白浆视频| 国产美女在线精品免费观看| 国产黄在线观看免费观看不卡| 亚洲国产成人精品激情姿源 | 爆乳护士一区二区三区在线播放| 在线观看无码av网址| 午夜精品久久久久久久| 久久先锋男人av资源网站| 国产欧美日韩综合在线成| 欧美潮喷少妇100| 天天躁日日躁狠狠躁欧美老妇 | 久久婷婷久久一区二区三区| 欧美日韩人成视频在线播放| 男人添女人下部高潮全视频| 色翁荡熄又大又硬又粗又视频| 一本一道波多野结衣一区| 亚洲无线码一区二区三区| 特黄特色大片免费播放器图片| 性人久久网av| 非洲黑人性xxxx精品| 中文无码人妻影音先锋| a一区二区三区乱码在线 | 欧洲| 国内精品视这里只有精品| 俺去啦俺来也五月天| 四虎成人精品无码| 久久视频在线视频| 国产在线码观看清码视频| 久久久久久久精品成人热色戒汤唯 | 国产精品人人做人人爽| 日韩精品久久久久久久电影蜜臀| 97视频热人人精品免费| 国产性色播播毛片| 久久亚洲私人国产精品| 精产国品一二三产区9977|