在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FOXK1 Antibody

FOXK1 Antibody

  • 中文名稱：
    FOXK1兔多克隆抗體
  • 貨號：
    CSB-PA074130
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from Jurkat cells, using FOXK1 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FOXK1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FOXK1
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human FOXK1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4. Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate. Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism. Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins. Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle. Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population. Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation. Involved in remodeling processes of adult muscles that occur in response to physiological stimuli. Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair. Represses myogenic differentiation by inhibiting MEFC activity. Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus. Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression.
  • 基因功能參考文獻：
    1. Knockdown of FOXK1 reduced cell viability and HK2 expression, decreased glucose consumption and lactate production in liver cancer cells. Furthermore, FOXK1 knockdown suppressed the activation of Akt/mTOR pathway. Inhibition of Akt/mTOR pathway reduced cell viability and glycolysis of liver cancer cells. PMID: 30312701
    2. Authors show that a nuclear-cytoplasmic transport system is necessary for the mTORC1-FOXK1 signal transduction. This reaction is mediated by a shuttling protein B56, which is a regulatory subunit of PP2A and plays an essential role in the mTORC1-dependent dephosphorylation of FOXK1. PMID: 29845697
    3. Results demonstrated that knockdown of FOXK1 inhibited the proliferation and metastasis of prostate cancer, at least in part, through suppressing the Wnt/beta-catenin signaling pathway. PMID: 28267429
    4. demonstrated that circMAN2B2 acts as an oncogenic role in lung cancer through promoting FOXK1 expression by sponging miR-1275 PMID: 29550475
    5. Knockdown of FOXK1 significantly inhibited hepatocellular carcinoma cell proliferation, migration and invasion. PMID: 28551547
    6. For FOXK1 and KCNA7, the age effect on the sperm epigenome was replicated in an independent cohort of 188 sperm samples. PMID: 28171595
    7. The higher expression of FOXK1 could indicate a poor prognosis in colorectal carcinoma (CRC) patients since FOXK1 induces epithelial-mesenchymal transition and promotes CRC cell invasion in vitro and in vivo. PMID: 27223064
    8. FOXK1 was overexpressed in esophageal cancer (EC) tissues compared with corresponding non-tumor tissues using immunohistochemistry. And high FOXK1 expression was related to poor differentiation of EC. The Kaplan-Meier curve indicated that high FOXK1 expression may result in poor prognosis of EC patients. PMID: 29050933
    9. c-jun promoted FOXK1-mediated proliferation and metastasis via orthotopic implantation. PMID: 27882939
    10. These findings implicate FOXK1 as a cell cycle and growth modulator that inhibits apoptosis in colon cancer cells. FOXK1-shRNA may serve as a novel and potent therapeutic agent, alone or with 5-FU, against colon cancer PMID: 27571921
    11. Data indicated the function of Foxk1 as a tumor suppressor in facilitating angiogenesis and metastasis in breast cancer. PMID: 26732382
    12. FOXK1 protein levels and activity are regulated by associating with JLP and PLK1 PMID: 26468278
    13. Overall, these results demonstrate a novel role for FOXK1 in regulating the expression of antiviral genes via Nup98, from insects to humans. PMID: 25852164
    14. FOXK1 and FOXK2 positively regulate Wnt/beta-catenin signaling by translocating dishevelled proteins into the nucleus. PMID: 25805136
    15. FOXK1 binds to the promoter and regulates expression of DHFR, TYMS, GSDMD, and the E2F binding partner TFDP1. PMID: 22740631
    16. crystallographic analysis of the FOXK1a-DNA complex PMID: 16624804

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.
  • 數據庫鏈接：

    HGNC: 23480

    OMIM: 616302

    KEGG: hsa:221937

    STRING: 9606.ENSP00000328720

    UniGene: Hs.487393



主站蜘蛛池模板： 天天做av天天爱天天爽| 精品综合久久久久久97| 亚洲欧美在线制服丝袜国产| 欧美自拍亚洲综合图区| 亚洲成在人线在线播放无码| 亚洲欧美另类久久久精品| 蜜臀av色欲a片无码精品一区| 亚洲人成伊人成综合网中文| 性色av无码专区一ⅴa亚洲| 国产老熟女狂叫对白| 五月婷婷久久草丁香| 亚洲成a人v影院色老汉影院| 精品无人乱码一区二区三区的特点| 亚洲午夜理论片在线观看| 丁香五月网久久综合| 中文字幕无线码中文字幕免费| 精品无码一区二区三区在线| 香蕉免费一区二区三区在 | 欧美人妻少妇精品久久黑人 | 国产成人a亚洲精v品无码| 白嫩日本少妇做爰| 少妇饥渴偷公乱av在线观看涩爱| 尤物蜜芽国产成人精品区| 久久国产色av免费观看| 狠狠色婷婷久久一区二区三区| 四虎永久在线精品免费网址| 亚洲日韩欧美国产另类综合| 夜夜天天噜狠狠爱2019| 性开放的女人aaa片| 亚洲永久网址在线观看| 亚洲视频无码高清在线| 国色天香社区视频| 亚洲va中文字幕| 国产做爰xxxⅹ高潮视频12p| 麻豆人妻无码性色av专区| 久久精品2021国产| 国产露脸150部国语对白| 国产精品久久一区二区三区| 国产乱子伦农村xxxx| 涩涩鲁亚洲精品一区二区| 日本免码va在线看免费|