在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FOXE3 Antibody

  • 中文名稱:
    FOXE3兔多克隆抗體
  • 貨號:
    CSB-PA008812GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    FOXE3
  • 別名:
    Drosphilia Forkhead Homolog Like 12 antibody; FKHL 12 antibody; FKHL12 antibody; Forkhead Box E3 antibody; Forkhead box protein E3 antibody; Forkhead Related Activator 8 antibody; Forkhead related protein FKHL12 antibody; Forkhead-related protein FKHL12 antibody; Forkhead-related transcription factor 8 antibody; Foxe3 antibody; FOXE3 forkhead box E3 antibody; FOXE3_HUMAN antibody; FREAC 8 antibody; FREAC-8 antibody; FREAC8 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human FOXE3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle. During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation. Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm. Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye.
  • 基因功能參考文獻:
    1. The sclerocornea-microphthalmia-aphakia complex is a severe malformative ocular phenotype resulting from mutations in the FOXE3 transcription factor. To date, patients from at least 14 families with this uncommon ocular disorder have been described. The identification of 2 novel pathogenic variants in our patients expands the mutational spectrum in FOXE3-related congenital eye disorders. PMID: 29878917
    2. Data show that DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1) is a transcriptional target of forkhead box protein E3 (FOXE3) in a pathway that is crucial for the development of the anterior segment of the eye. PMID: 27218149
    3. Although congenital aphakia is known to be caused by mutations in the FOXE3 gene, the results of lack of coding mutation in this patient suggests a possible genetic heterogeneity of the disease. PMID: 28805541
    4. Only one novel missense mutation in exon 1 of FOXE3 (Chr1:47,882,459, c.472G>C, p.Gly158Arg) was identified being homozygous in the three affected and heterozygous in the two unaffected, which was confirmed by Sanger sequencing. PMID: 27669367
    5. FOXE3 mutations lead to a reduced number of aortic smooth muscle cells (SMCs) during development and increased SMC apoptosis in the ascending aorta in response to increased biomechanical forces. PMID: 26854927
    6. This is the first functional evidence demonstrating that FOXE3 mutations identified in patients impair protein function with differential effects. PMID: 25504734
    7. Our results indicate that the FOXE3 p.Val201Met allele is associated with eye defects (OR = 3.5), suggesting its involvement as an ocular malformation risk factor. PMID: 24689660
    8. This study demonstrates that a cluster of patients with sclerocornea, aphakia, and microphthalmia in a small Mexican village is due to a FOXE3 p.Y98H founder mutation. PMID: 24019743
    9. shRNA-mediated gene silencing of FOXE3 could significantly inhibit cell growth and induce the G1-phase arrest in human lens epithelial cell line-3 cells. PMID: 22527307
    10. The FOXE3 mutation detected in c.601 G > A, predicting p.Val201Met which were not yet been included in public databases, but has previously been reported in both A/M patients. PMID: 22204637
    11. Autosomal-dominant mutations within FOXE3 cause anterior segment dysgenesis and has important clinical utility, especially for the diagnosis of mildly affected patients. PMID: 21150893
    12. Using autoantibodies from systemic sclerosis (SSc) patients, two anti-CENP-A-specific motifs were defined in its immunodominant epitope Ap17-30. One of these motifs matched residues 53-62 of FOXE3, a protein not previously implicated in SSc. PMID: 20630806
    13. This is the fourth report detailing homozygous FOXE3 mutations causing anterior segment abnormalities in human patients. PMID: 20664696
    14. Mutations in several transcription factors associated with aniridia and congenital cataract, FOXE3, (PAX6), PITX2, and PITX3 genes, were examined. PMID: 20806047
    15. FOXE3 is responsible for the early developmental arrest of the lens placode, and the complete loss of a functional FOXE3 protein results in primary aphakia. PMID: 20361012
    16. Recessive mutations in FOXE3 were found in four of 26 probands affected with bilateral microphthalmia (15% of all bilateral microphthalmia and 100% of consanguineous families with this phenotype). PMID: 20140963
    17. Role very early in the lens developmental program, perhaps earlier than any role recognized elsewhere for this gene. PMID: 16826526
    18. findings suggest that mutations in FOXE3 can give rise to a broad spectrum of eye anomalies, largely, but not exclusively related to lens development, and that both dominant and recessive inheritance patterns can be represented PMID: 19708017
    19. FOXE3 is essential for closure of the lens vesicle during eye development and for lens epithelial survival and proliferation. PMID: 10652278

    顯示更多

    收起更多

  • 相關疾病:
    Anterior segment dysgenesis 2 (ASGD2); Cataract 34, multiple types (CTRCT34); Aortic aneurysm, familial thoracic 11 (AAT11)
  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 3808

    OMIM: 601094

    KEGG: hsa:2301

    STRING: 9606.ENSP00000334472

    UniGene: Hs.112968



主站蜘蛛池模板: 在线亚洲人成电影网站色www| 香蕉啪视频在线观看视频久| 2021久久超碰国产精品最新| 18无码粉嫩小泬无套在线观看 | 午夜成人性刺激免费视频| 亚洲精品一区二区三区中文字幕 | 中国白嫩丰满人妻videos| 乱女伦露脸对白在线播放| 人与禽性视频77777| 97久久婷婷五月综合色d啪蜜芽 | 天堂一区人妻无码| 四虎亚洲精品无码| 牛和人交videos欧美| 国产欧美在线观看不卡| 3d动漫精品一区二区三区| 草草影院精品一区二区三区| 欧美日韩亚洲国产在线制服 | 99精品视频一区在线观看| 国产尤物在线视精品在亚洲| 成年女人永久免费观看视频| 少妇高清精品毛片在线视频| 成人做爰高潮片免费视频| 人妻丰满熟av无码区hd| 久久人妻内射无码一区三区| 亚洲午夜无码久久久久蜜臀av| 国语自产拍在线观看对白| 内射精品无码中文字幕| 亚洲成a人片在线观看高清| 137裸交肉体摄影| 亚洲hdmi高清线| 麻豆av福利av久久av| 上司揉捏人妻丰满双乳电影| 中文字幕一区日韩精品| 午夜天堂av天堂久久久| aaaaa少妇高潮大片| 国产成人亚洲综合网站小说| 性高朝久久久久久久久久| 欧美xxxx做受欧美| 精品无人区码一码二码三码区别| 大战丰满无码人妻50p| 国产日韩精品中文字无码|