在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FNIP1 Antibody, Biotin conjugated

  • 中文名稱:
    FNIP1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA819483LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FNIP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    FNIP1 antibody; KIAA1961Folliculin-interacting protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Folliculin-interacting protein 1 protein (221-508AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3. In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3. Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3. Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases. Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy. In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90. Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal. Required for B-cell development.
  • 基因功能參考文獻:
    1. The FLCN-FNIP complex deregulated in Birt-Hogg-Dube syndrome is absolutely required for B-cell differentiation. PMID: 22709692
    2. Results suggest that FLCN, mutated in Birt-Hogg-Dube syndrome, and its interacting partner FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. PMID: 17028174
  • 亞細胞定位:
    Lysosome membrane. Cytoplasm, cytosol.
  • 蛋白家族:
    FNIP family
  • 組織特異性:
    Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney t
  • 數據庫鏈接:

    HGNC: 29418

    OMIM: 610594

    KEGG: hsa:96459

    STRING: 9606.ENSP00000421985

    UniGene: Hs.591273



主站蜘蛛池模板: 欧美高潮喷水大叫| 瑜伽裤国产一区二区三区| 婷婷综合久久中文字幕蜜桃三电影| 中文精品一卡2卡3卡4卡国色| 99精品国产福利一区二区| 熟妇玩小男视频在线| 亚洲人成人无码网www电影首页| 国产av人人夜夜澡人人爽麻豆| 2018国产精华国产精品| 亚洲va天堂va欧美片a在线| 久久高清超碰av热热久久| 亚洲性猛交xxxx| 国产毛a片啊久久久久久保和丸 | 成人精品一区日本无码网| 人妻少妇heyzo无码专区| 久久精品人人做人人爽老司机| 边喂奶边中出的人妻| 99精品久久毛片a片| 日本高清视频网站www| 精品亚洲成a人片在线观看| 日本黄页网站免费大全| 无码 人妻 在线 视频| 亚洲精品色无码av试看| 亚洲日本乱码中文在线电影 | 成人免费无码大片a毛片户外 | 5d肉蒲团之性战奶水| 日本丰满熟妇videossex一| 亚洲精品国产品国语原创| 亚洲精品国产一区二区的区别| 国产真人无遮挡作爱免费视频| 忍着娇喘人妻被中出中文字幕| 久久热最新网站获取| 66亚洲一卡2卡新区成片发布| 欧美激情精品久久久久久| 西西人体大胆扒开下部337卩| 亚洲人色婷婷成人网站在线观看| 18禁无遮挡免费视频网站| 国产情侣草莓视频在线| 亚洲人成77777在线播放网站不卡| 亚洲精品一区二区久久| 日本熟妇人妻xxxxx人hd|