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FMO5 Antibody

  • 中文名稱:
    FMO5兔多克隆抗體
  • 貨號:
    CSB-PA008751ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: FMO5 antibody at 6.04 μg/ml + Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 61, 33, 53 kDa
      Observed band size: 61 kDa
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA008751ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA008751ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FMO5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FMO5
  • 別名:
    Dimethylaniline monooxygenase [N oxide forming] 5 antibody; Dimethylaniline monooxygenase [N-oxide-forming] 5 antibody; Dimethylaniline oxidase 5 antibody; FMO 5 antibody; FMO5 antibody; FMO5_HUMAN antibody; Hepatic flavin containing monooxygenase 5 antibody; Hepatic flavin-containing monooxygenase 5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Dimethylaniline monooxygenase [N-oxide-forming] 5 protein (1-285AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.
  • 基因功能參考文獻:
    1. Report relatively stable FMO5 expression throughout development. PMID: 26839369
    2. Nabumetone and pentoxifylline, two widely used pharmaceuticals, were thereby demonstrated to be efficiently oxidized in vitro by FMO5 to the corresponding acetate esters with high selectivity. PMID: 28783300
    3. absence of the typical characteristic sequence motifs sets human FMO5 apart from all characterized Baeyer-Villiger mono-oxygenases so far. These findings open new perspectives in human oxidative metabolism PMID: 26771671
    4. fmo5 displayed a significant, dominant liver-specific mRNA profile. PMID: 16183778
  • 亞細胞定位:
    Microsome membrane. Endoplasmic reticulum membrane.
  • 蛋白家族:
    FMO family
  • 組織特異性:
    Expressed in fetal and adult liver.
  • 數據庫鏈接:

    HGNC: 3773

    OMIM: 603957

    KEGG: hsa:2330

    STRING: 9606.ENSP00000254090

    UniGene: Hs.642706



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