在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FLII Antibody

  • 中文名稱:
    FLII兔多克隆抗體
  • 貨號:
    CSB-PA008715GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    FLII
  • 別名:
    Fli 1 antibody; FLI antibody; Fli1 antibody; Flightless 1 antibody; Flightless I (Drosophila) homolog antibody; Flightless I homolog antibody; Flightless I homolog (Drosophila) antibody; Flightless1 antibody; FlightlessI antibody; fliI antibody; FLII_HUMAN antibody; Fliih antibody; FLIL antibody; MGC39265 antibody; Protein flightless 1 homolog antibody; Protein flightless-1 homolog antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human FLII
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.
  • 基因功能參考文獻:
    1. Low FLII expression is associated with lung carcinoma. PMID: 28498392
    2. Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages. PMID: 27431477
    3. FLII is a component of the ChREBP transcriptional complex and negatively regulates ChREBP function in cancer cells. PMID: 24055811
    4. Demonstrate an important role for Flii in the development and regulation of the epidermal barrier, which may contribute to the impaired healing and skin fragility of epidermolysis bullosa patients. PMID: 24375017
    5. FLII is associated with SENP3 and the MLL1/2 complex and FLII is indispensible for H3K4 methylation and proper loading of active RNA polymerase II at this gene locus. PMID: 28344658
    6. Flightless-I (Drosophila) homolog (FLII) activates TGFbeta1-mediated expression of COL1A2 gene. PMID: 25451260
    7. Studies suggest that Flii enhances cutaneous squamous cell carcinoma progression by decreasing apoptosis and enhancing tumor cell invasion. PMID: 26497552
    8. FLII plays a tumor-suppressive role and serves as a crucial determinant of resistance of prostate cancer to endocrine therapies. PMID: 26527749
    9. These data suggest FLII as a key regulator of ERalpha-mediated transcription through its role in regulating chromatin accessibility for the binding of RNA Polymerase II and possibly other transcriptional coactivators. PMID: 24632205
    10. Flii is constitutively secreted from macrophages and fibroblasts and is present in human plasma. PMID: 22718342
    11. Fli-I promotes the GTP-bound active Rho-mediated relief of the autoinhibition of Daam1 and mDia1. Thus, Fli-I is a novel positive regulator of Rho-induced linear actin assembly mediated by DRFs. PMID: 20223827
    12. performs an essential function in early embryonic development PMID: 11971982
    13. These data suggest that Flightless-I may facilitate interaction of the p160 coactivator complex with other coactivators or coactivator complexes containing actin or actin-like proteins. PMID: 14966289
    14. effect of FliI protein on actin remodelling is a vital part of cellular motility, contraction and adhesion. Exact signaling pathways and mechanisms underpinning FliI effects in wound healing are yet to be fully identified[review] PMID: 17526423
    15. These findings support a novel mechanism whereby cytosolic CaMK-II influences beta-catenin dependent gene expression through Fli-I. PMID: 18588881
    16. The interactions between MyD88 and multiple positive and negative regulators LRRFIP2, FLAP-1, and Fliih are highly dynamic and time-course dependent in differentially regulating/modulating NF-kappa B signal transduction. PMID: 19265123
    17. These findings support the model that CISK phosphorylates FLII and activates nuclear receptor transcription and suggest a new cell survival signaling pathway mediated by PI 3-kinase and CISK. PMID: 19293151
    18. Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I. PMID: 19720835

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion.
  • 組織特異性:
    Strongest expression in skeletal muscle with high expression also in the heart and lung.
  • 數據庫鏈接:

    HGNC: 3750

    OMIM: 600362

    KEGG: hsa:2314

    STRING: 9606.ENSP00000324573

    UniGene: Hs.513984



主站蜘蛛池模板: 窝窝午夜看片| 最新国产精品无码| 国产99爱在线视频免费观看| 无码人妻一区二区三区免费看成人| 四虎永久地址www成人| 夜夜爽妓女8888视频免费观看| 国产又黄又刺激又高潮的网站 | 欧美两根一起进3p在线观看 | 精品综合久久久久久8888| av天堂午夜精品一区| 国产麻豆9l精品三级站| 亚洲精品欧美综合一区二区| 日韩a人毛片精品无人区乱码| 好大好硬好爽免费视频| 亚洲第一成人网站| 狠狠人妻久久久久久综合| 麻花传媒剧国产mv高清播放| 国产精品午夜视频自在拍| 天天摸天天做天天爽| 亚洲色婷婷六月亚洲婷婷6月| 337p粉嫩日本欧洲亚福利| 伊人久久大香线蕉成人| av老司机亚洲精品天堂| 精品一区二区三区无码免费视频| 久久精品国产第一区二区三区| 国产精品福利2020久久| 国产精品va无码免费| 亚洲国产精品一区二区久久hs| 2019久久视频这里有精品15| 香港三级日本三级韩级人妇| av在线播放日韩亚洲欧| 日韩精品无码一本二本三本| 国产草莓视频无码a在线观看| 自慰无码一区二区三区| 亚洲欧美日韩精品色xxx| 春药玩弄少妇高潮吼叫| 国产成人啪精品视频网站午夜| 亚洲中文字幕无码久久精品1| 在线视频夫妻内射| 在线观看高h无码黄动漫| 国产麻无矿码直接观看|