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FKBP3 Antibody

  • 中文名稱:
    FKBP3兔多克隆抗體
  • 貨號:
    CSB-PA008699GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    FKBP3
  • 別名:
    25 kDa FK506-binding protein antibody; 25 kDa FKBP antibody; FK506 binding protein 25 T cell antibody; FK506 binding protein 25; T cell; 25-KD antibody; FK506 binding protein 3 (25kD) antibody; FK506-binding protein 3 antibody; FKBP 25 antibody; FKBP 3 antibody; FKBP-25 antibody; FKBP-3 antibody; FKBP25 antibody; FKBP3 antibody; FKBP3_HUMAN antibody; Immunophilin FKBP25 antibody; Peptidyl-prolyl cis-trans isomerase FKBP3 antibody; PPIase antibody; PPIase FKBP3 antibody; Rapamycin binding protein antibody; Rapamycin-selective 25 kDa immunophilin antibody; Rotamase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human FKBP3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.
  • 基因功能參考文獻:
    1. Taken together, these data clearly show that FKBP3/Sp1/HDAC2/p27 control cell proliferation during non-small cell lung cancer development. PMID: 28839465
    2. Data show that the N-terminus of FK506 binding protein-25 (FKBP25) is anchored to regions of dsRNA, whereas the FKBP domain is free to interact with neighboring proteins. PMID: 29036638
    3. Structural basis for nucleic acid recognition by FKBP25 has been uncovered. PMID: 26762975
    4. proteomics study indicates that the nuclear pool of the FKBP25 targets various nuclear proteins that are crucial for packaging of DNA, chromatin remodeling and pre-mRNA splicing PMID: 24998444
    5. FKBP25 is likely recruited to preribosomes to chaperone one of the protein components of the ribosome large subunit. PMID: 24840943
    6. structure of a unique N-terminal domain motif in the FKBP family, FKBP25(1-73), high-resolution structures show a new fold composed of five small helices where H3 and H4 are tilted in a novel arrangement; called Basic Tilted Helix Bundle (BTHB) domain. PMID: 24667607
    7. FKBP3, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53. PMID: 19166840

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  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    FKBP-type PPIase family
  • 數據庫鏈接:

    HGNC: 3719

    OMIM: 186947

    KEGG: hsa:2287

    STRING: 9606.ENSP00000216330

    UniGene: Hs.509226



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