在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FKBP1B Antibody

  • 中文名稱:
    FKBP1B兔多克隆抗體
  • 貨號:
    CSB-PA008692LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunofluorescence staining of SH-SY5Y cells with CSB-PA008692LA01HU-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) FKBP1B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FKBP1B
  • 別名:
    Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase) (h-FKBP-12), FKBP1B, FKBP12.6 FKBP1L FKBP9 OTK4
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP1B protein (1-108aa)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,F(xiàn)KBP1B Antibody (CSB-PA008692LA01HU),的標(biāo)記方式是Non-conjugated。對于FKBP1B Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA008692LB01HU FKBP1B Antibody, HRP conjugated ELISA
    FITC CSB-PA008692LC01HU FKBP1B Antibody, FITC conjugated
    Biotin CSB-PA008692LD01HU FKBP1B Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • 基因功能參考文獻:
    1. Our FRET-based HTS detects RyR binding of accessory proteins calmodulin (CaM) or FKBP12.6...One compound increased FRET and inhibited RyR1, which was only significant at nM [Ca(2+)], and accentuated without CaM present. PMID: 27760856
    2. Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2 PMID: 27670942
    3. results suggest that both FKBP12.6 and FKBP12 play critical roles in regulating RyR2 function by facilitating the termination of SOICR. PMID: 27154203
    4. Sirolimus-FKBP12.6 impairs endothelial barrier function by activation of protein kinase C-alpha and downstream disruption of the p120-VE cadherin interaction in vascular endothelium. PMID: 23887639
    5. FKBP12.6-deficient mice with cardiac hypertrophy do not display exercise-induced arrhythmia and/or sudden cardiac death. PMID: 22087651
    6. analysis of the ryanodine receptor FK506-binding protein subunit PMID: 20404344
    7. Characterize the kinetics of FKBP12/12.6 binding to RyR2 in ventricular myocytes and effects on calcium signaling. PMID: 20431056
    8. localization of binding site to the NH2-terminal domain of the cardiac Ca2+ release channel PMID: 12446682
    9. Data show that VTSIP- and ARVD2-associated point mutations influence positively and negatively, respectively, the binding of RyR2 to its gating protein FKBP12.6. PMID: 12459180
    10. data demonstrate that defective regulation of ryanodine receptor 2 causes altered cellular phenotype via profound perturbations in intracellular calcium signaling and highlight a key modulatory role of FK506 binding protein 12.6 PMID: 12754204
    11. FKBP1B gene is involved in the genetic susceptibility to the AITDs development in the studied family. PMID: 15497458
    12. novel interaction site for FKBP12.6 may be present at the RyR2 C terminus, proximal to the channel pore, a sterically appropriate location that would enable this protein to play a central role in the modulation of this critical ion channel PMID: 15591045
    13. FKBP12.6 plays a critical role in Ca channel gating, the R2401H mutation can be expected to alter Ca-induced Ca release and E-C coupling resulting in CPVT. PMID: 15749201
    14. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. PMID: 15972811
    15. the redox state of the RyR is intimately connected with FKBP binding affinity. PMID: 17200109
    16. Data show that K201 abolished spontaneous calcium release in cardiac myocytes, and that treating ventricular myocytes with FK506 to dissociate FKBP12.6 from ryanodine receptor RyR2 did not affect the suppression of spontaneous Ca2+ release by K201. PMID: 17313373
    17. Results describe abrupt changes in the expression of FKBP12.6, SERCA2a, PKA, and ECE on reperfusion against ischemia, which are responsible for the rapid occurrence of ventricular fibrillation, and their prevention by CPU86017. PMID: 17506935
    18. the loss of FKBP12.6 has no significant effect on the conduction and activation of RyR2 or the propensity for spontaneous Ca(2+) release and stress-induced ventricular arrhythmias PMID: 17921453
    19. The findings suggest that FKBP12.6 regulation of RyR2 is unlikely to be the primary defect in inherited arrhythmogenic cardiac disease. PMID: 19226252

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Sarcoplasmic reticulum.
  • 蛋白家族:
    FKBP-type PPIase family, FKBP1 subfamily
  • 組織特異性:
    Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3712

    OMIM: 600620

    KEGG: hsa:2281

    STRING: 9606.ENSP00000370373

    UniGene: Hs.709461



主站蜘蛛池模板: 久久综合97丁香色香蕉| 九一九色国产| 在线天堂新版最新版在线8| 日日摸天天摸人人看| 久久精品亚洲中文无东京热| 中文无码伦av中文字幕| 亚洲色成人一区二区三区小说 | 国产性猛交╳xxx乱大交| 亚洲高清专区日韩精品| 少妇无码av无码去区钱| 国产午夜福利片在线观看| 国产成人亚洲精品狼色在线| 精品国产一区二区三区av孞弋| 亚洲欧洲综合有码无码| 亚洲一区二区三区四区 | 狠狠狠狼鲁亚洲综合网| 老司机久久99久久精品播放免费| 欧洲精品无码一区二区三区在线播放 | 黄网站色视频免费观看| 丰满多毛少妇做爰视频爽爽和 | 国产在线 | 中文| 碰超免费人妻中文字幕| 亚洲国产欧美在线观看片不卡| 亚洲熟女综合色一区二区三区| 国内精品久久毛片一区二区| 中文乱码免费一区二区| 天天摸天天做天天添欧美| 亚洲男女一区二区三区| 高清欧美性猛交xxxx黑人猛交| 亚洲第一最快av网站| 精品无码国产日韩制服丝袜| 久久国产精品波多野结衣av| 中国熟妇浓毛hdsex| 日本老熟妇乱子伦视频| 国产精品久久久福利| 中文在线а√天堂官网| 成人a片产无码免费视频在线观看| 丰满人妻被黑人连续中出| 放荡的少妇2欧美版| 欧美激情一区二区三区高清视频 | 中文字幕乱人伦高清视频|