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FKBP10 Antibody, Biotin conjugated

  • 中文名稱:
    FKBP10兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA822180LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FKBP10 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    FKBP10 antibody; FKBP65 antibody; PSEC0056Peptidyl-prolyl cis-trans isomerase FKBP10 antibody; PPIase FKBP10 antibody; EC 5.2.1.8 antibody; 65 kDa FK506-binding protein antibody; 65 kDa FKBP antibody; FKBP-65 antibody; FK506-binding protein 10 antibody; FKBP-10 antibody; Immunophilin FKBP65 antibody; Rotamase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP10 protein (459-579AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    PPIases accelerate the folding of proteins during protein synthesis.
  • 基因功能參考文獻:
    1. FKBP10 interacts with collagen VI and deficiency of FKBP10 reduces lung fibroblast migration by down-regulation of collage VI synthesis. PMID: 29673351
    2. Data found novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta PMID: 29512769
    3. an endoplasmic reticulum complex of resident chaperones that includes HSP47, FKBP65, and BiP regulating the activity of LH2. PMID: 28177155
    4. FKBP10 protein is overexpressed in renal cell carcinoma PMID: 27602571
    5. FKBP65 is linked to pyridinoline cross-linking by specifically mediating the dimerization of LH2. PMID: 27298363
    6. novel pathogenic mutations of FKBP10 can lead to the extremely rare type XI Osteogenesis imperfecta without contractures, which expands the genotypic spectrum of Osteogenesis imperfecta. PMID: 27762305
    7. Mutations in FKBP10, localised to chromosome 17q21, have been identified in a patient of Bruck syndrome. Additional cases are also discussed. PMID: 25931047
    8. A pathogenic change was found in the FKBP10 gene in patients with osteogenesis imperfecta. PMID: 27706701
    9. findings further extend the body of evidence that supports the importance of FKBP10 gene in the development of skeletal system PMID: 26538303
    10. Mutations in the HSP47 and FKBP65 produce a moderately severe form of Osteogenesis imperfect. PMID: 25510505
    11. CTSD, FKBP10, and SLC2A1 are novel genes that participate in the acquisition and maintenance of the adriamycin-resistant phenotype in leukemia cells. PMID: 24467213
    12. Results imply that FKBP10 mutations affect collagen indirectly, by ablating FKBP65 support for collagen telopeptide hydroxylation by lysyl hydroxylase 2, thus decreasing collagen cross-links in tendon and bone matrix. PMID: 23712425
    13. Elastin binding protein and FKBP65 modulate the kinetics of self-assembly of tropoelastin in an in vitro system. PMID: 24106871
    14. FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts PMID: 23434032
    15. underexpression of FKBP65 protein is characteristic of high-grade serous carcinomas and this expression profile may be linked to molecular pathways associated with an unfavourable outcome in cancer patients. PMID: 23354471
    16. FKBP10 acts during procollagen maturation to contribute to molecular stability and post-translational modification of type I procollagen, without which bone mass and quality are abnormal and fractures and contractures result PMID: 22949511
    17. identified a Palestinian pedigree with moderate and lethal forms of recessive OI caused by mutations in FKBP10 or PPIB, which encode endoplasmic reticulum resident chaperone/isomerases FKBP65 and CyPB, respectively PMID: 22718341
    18. Homozygosity mapping identified FKBP10 as a candidate gene, and sequencing revealed a base pair exchange that causes a C-terminal premature stop codon in this gene. PMID: 22107750
    19. Mutations in FKBP10 cause both Bruck syndrome and isolated osteogenesis imperfecta in humans. PMID: 21567934
    20. The differential expression of FKBP65 indicates a role in ovarian physiology as well as in ovarian tumor development PMID: 21399973
    21. FKBP10 mutations are a cause of recessive osteogenesis imperfecta and Bruck syndrome. PMID: 20839288
    22. Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta. PMID: 20362275

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  • 相關疾病:
    Osteogenesis imperfecta 11 (OI11); Bruck syndrome 1 (BRKS1)
  • 亞細胞定位:
    Endoplasmic reticulum lumen.
  • 數據庫鏈接:

    HGNC: 18169

    OMIM: 259450

    KEGG: hsa:60681

    STRING: 9606.ENSP00000317232

    UniGene: Hs.463035



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