在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FHOD1 Antibody, HRP conjugated

  • 中文名稱:
    FHOD1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA896540LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FHOD1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FHOD1
  • 別名:
    FH1/FH2 domain containing protein antibody; FH1/FH2 domain containing protein 1 antibody; FH1/FH2 domain-containing protein 1 antibody; Fhod1 antibody; FHOD1_HUMAN antibody; FHOS antibody; FHOS1 antibody; Formin homolog overexpressed in spleen 1 antibody; Formin homology 2 domain containing 1 antibody; Formin homology 2 domain containing protein 1 antibody; Formin homology 2 domain-containing protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human FH1/FH2 domain-containing protein 1 protein (338-437AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.
  • 基因功能參考文獻:
    1. results suggest that FHOD1 participates in key cellular processes that are dysregulated in malignancy PMID: 27919746
    2. FHOD1 and INF2 are novel regulators of inter- and intra-structural contractility of podosomes. PMID: 26621033
    3. Immunostaining of sections of hearts with both anti-FHOD1 antibodies confirmed the presence of FHOD1 in intercalated discs and double immunostaining demonstrated its colocalisation with cadherin, plakoglobin and shifted localization to connexin43. PMID: 25555464
    4. Report FODH1 expression in cardiomyocytes and increased expression in dilated cardiommyopathy. PMID: 25125170
    5. FHOD1 promotes formation of short actin filaments and transiently associates with transverse arcs providing tight temporal and spatial control of the formation and turnover of transverse arcs into mature ventral stress fibers during dynamic cell behavior. PMID: 24481812
    6. the diaphanous formin FHOD1 as an interaction partner of N2G PMID: 24880667
    7. FHOD1 participates in cytoskeletal changes in epithelial-mesenchymal transition. PMID: 24086398
    8. Cdh1 contributes to spatiotemporal organization of AurB activity, and organization of FHOD1 activity by AurB contributes to daughter cell spreading after mitosis. PMID: 23613471
    9. FHOD1 stabilizes actin filaments by protecting barbed ends from depolymerization with its dimeric FH2 domain, whereas the region N-terminal to the FH1 domain mediates F-actin bundling by simultaneously binding to the sides of adjacent F-actin filaments. PMID: 23444374
    10. SIRPalpha/CD172a and FHOD1 are unique markers of littoral cells, a recently evolved major cell population of red pulp of human spleen. PMID: 22490440
    11. FHOD1 and PPM1F (direct regulators of the actin cytoskeleton) were identified as novel targets of miR-200c. Expression levels of FHOD1 and PPM1F were inversely correlated with miR-200c level in breast cancer cell lines and breast cancer patient samples. PMID: 22144583
    12. Letter: G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets. PMID: 21605332
    13. FHOD1 is a critical regulator of smooth muscle cell phenotype and is regulated by ROCK-dependent phosphorylation. PMID: 21106951
    14. FHOS mediates an interaction between GLUT4/IRAP (insulin-responsive aminopeptidase) -containing vesicles and the cytoskeleton and may participate in exocytosis and/or retention of this membrane compartment PMID: 12677009
    15. Fhos directly binds to F-actin via the N-terminal region, forms a homotypic complex via the FH2 domain to organize actin cytoskeleton PMID: 14576350
    16. FHOD1 has a role in cyclic GMP-dependent inhibition of vascular smooth muscle cell stress fiber formation and/or migration PMID: 15051728
    17. Oligomerization of FHOD1 via the coiled-coil motif is a critical parameter for its biological activities. PMID: 15642356
    18. Sustained cell elongation is a consequence of FHOD1-mediated actin-microtubule coordination. PMID: 15878344
    19. These novel data demonstrate that FHOD1-ERK MAP kinase interaction regulates key aspects of FHOD1 biology. PMID: 16112087
    20. in FHOD1, DAD acts as signal sequence for binding to the well folded and monomeric FH3 domain PMID: 16361249
    21. This study demonstrates FHOD1 is cleaved by caspase-3 at the SVPD(616) site during apoptosis and the C-terminal FHOD1 cleavage product has the ability to inhibit RNA polymerase I transcription. PMID: 17013756
    22. In this study, the N-terminal region (residues 1-339) of the human formin homology domain-containing protein 1 (FHOD1) was purified and crystallized. PMID: 17909294
    23. FHOD1 is activated through phosphorylation by rho-dependent protein kinase (ROCK)and has an important function in stress fibre formation in vascular endothelial cells PMID: 18239683
    24. The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing. PMID: 18694941
    25. Mutation of one residue in the predicted DAD-interaction surface efficiently activates FHOD1 in cells. PMID: 18786395

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic.
  • 蛋白家族:
    Formin homology family
  • 組織特異性:
    Ubiquitous. Highly expressed in spleen.
  • 數據庫鏈接:

    HGNC: 17905

    OMIM: 606881

    KEGG: hsa:29109

    STRING: 9606.ENSP00000258201

    UniGene: Hs.95231



主站蜘蛛池模板: 亚洲国产色播av在线| 麻豆蜜桃av蜜臀av色欲av| 亚洲已满18点击进入在线观看| 国产v在线最新观看视频| 中文字幕一区二区三区四区五区| 曰批视频免费30分钟成人| 欧美乱妇高清无乱码| 18禁裸体女免费观看| 日本丰满少妇xxxx| 欧洲亚洲国产成人综合色婷婷| 丰满的少妇hd高清中文字幕| 一区二区免费高清观看国产丝瓜 | 玩弄少妇人妻| 中文字幕乱码无码人妻系列蜜桃| 狼群社区www中文视频| 小草国产精品情侣| 男人j桶进女人p无遮挡免费观看| 国产精品视频白浆免费视频| 97在线成人国产在线视频| 国产亚洲色欲色一色www| 男人j进入女人j内部免费网站| 无套内射视频囯产| 人妻无码久久中文字幕专区| 日本一卡二卡四卡无卡国产| 麻豆av福利av久久av| 国产精品无码av天天爽| 欧美综合精品久久久久成人影院| 中日产幕无线码一区| 1000部啪啪未满十八勿入| 午夜精品久久久久久久爽| 国产精品内射视频免费| 黑人巨大av无码专区| 国产乱子夫妻xx黑人xyx真爽| 亚洲精品国产成人99久久6 | 亚洲精品久久久久avwww潮水| 国偷自产av一区二区三区| 国产精品三级国产电影| 视频久re精品在线观看| 国产精品久久国产三级国不卡顿 | 午夜福利一区二区三区高清视频| 久久天天躁狠狠躁夜夜躁app|