在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FFAR2 Antibody, FITC conjugated

FFAR2 Antibody, FITC conjugated

  • 中文名稱：
    FFAR2兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA008605LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FFAR2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FFAR2; FFA2; GPCR43; GPR43; Free fatty acid receptor 2; G-protein coupled receptor 43
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Free fatty acid receptor 2 protein (277-330AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate. Exhibits a SCFA-independent constitutive G protein-coupled receptor activity.
  • 基因功能參考文獻：
    1. Data suggest that the free fatty acid receptor 2 (FFA2/GPR43 receptor) plays an integral role in survival during and after sepsis. PMID: 29338778
    2. we show functional similarities but also some important differences between GPR84 and FFA2R in human phagocytes, thus providing some mechanistic insights into GPR84 regulation in blood neutrophils and cells recruited to an aseptic inflammatory site in vivo. PMID: 29477577
    3. Compared with the control group, the densitometric quantification and mean density of GPR43 and ChAT proteins, and expression of GPR43 and CHAT genes, were significantly decreased in the patients with mixed refractory constipation. PMID: 26921846
    4. FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11. PMID: 27385588
    5. the results of mutagenesis studies based on the crystal structure of hFFA1 bound to TAK-875 at 2.3 A resolution to identify important residues for orthosteric agonist 6e inducing FFA2 activation. PMID: 26808470
    6. Although both agonist and antagonist ligands contain negatively charged carboxylates that interact with two key positively charged arginine residues in transmembrane domains V and VII of FFA2, there are clear differences in how these interactions occur. PMID: 26518871
    7. FFAR2 signaling occurs by divergent G protein pathways. PMID: 26075576
    8. GPR3 agonism potentiates insulin secretion in isolated islets. PMID: 26023106
    9. GPR43 expression is reduced in monocytes upon siRNA-knockdown of XBP1, while A549 cells overexpressing XBP1 displayed elevated GPR43 levels. PMID: 25633224
    10. FFAR2 is a potential therapeutic target of T1 diabetes, representing a link between immune response and glucose homeostasis. PMID: 25298143
    11. FFAR2 is expressed in pancreatic beta cells and mediates an inhibition of insulin secretion by coupling to Gi-type G proteins. PMID: 25581519
    12. [review] In vivo and in vitro studies suggest that short-chain fatty acid receptors (SCFAs) stimulate gut hormone secretion; therefore, the SCFA-FFA signal is likely to be important for gut physiological functions. PMID: 24458110
    13. GPR43 modulates NF-kappaB activity via beta-arrestin 2. PMID: 23985900
    14. Data indicate that a single mutation in human FFA2 of C4.57G resulted in a human FFA2 receptor with ligand selectivity similar to the bovine receptor. PMID: 22919070
    15. They report the results of mutagenesis studies on the receptor, and the identification of previous unknown residues that may affect receptor activation as well as residues important for allosteric interactions on FFA2. PMID: 21216233
    16. Reduction of GPR43 expression is associated with colon cancers. PMID: 20979106
    17. Collaboration among C-reactive protein, M-ficolin, and GPR43 under acidosis curtails interleukin (IL)-8 production, thus preventing immune overactivation during bacterial infection. PMID: 21037097
    18. Mutational analysis revealed several important residues located in transmembrane domains 3, 4, 5, 6, and 7 for acetate binding. PMID: 20837008
    19. upregulation of FFAR2 expression may contribute to malignant transformation. PMID: 19780758
    20. might play pivotal role in differentiation and immune response of monocytes and granulocytes PMID: 12393494
    21. FFA2R is expressed on leukocytes and activated by short-chain fatty acids. PMID: 12684041
    22. the highly selective expression of GPR43 in leukocytes, particularly polymorphonuclear cells, suggests a role in the recruitment of these cell populations toward sites of bacterial infection PMID: 12711604
    23. Results indicate that the short chain fatty acid receptor, GPR43 is expressed by enteroendocrine L cells containing peptide YY in the human large intestine. PMID: 17899402

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Expressed at relatively high levels in peripheral blood leukocytes and, to lesser extent, in spleen.
  • 數據庫鏈接：

    HGNC: 4501

    OMIM: 603823

    KEGG: hsa:2867

    STRING: 9606.ENSP00000246549

    UniGene: Hs.248056



主站蜘蛛池模板： 美女啪啪网站又黄又免费| 国产视频一区二区| 亚洲人成在线影院| 亚洲欧美国产毛片在线| 国产精品视频一区二区亚瑟| 国内精品久久久久久影院8f| 欧美丰满熟妇bbb久久久| 国产成人精品无码专区| 久久久久国产精品人妻aⅴ院| 国产成人av大片在线观看| 日本熟人妻中文字幕在线| 18禁网站免费无遮挡无码中文| 医院人妻闷声隔着帘子被中出| 国产成人亚洲综合色婷婷秒播 | 免费观看的av毛片的网站| 欧美日韩欧美| 亚洲欧洲日产国码韩国| 护士av无码在线观看| 综合亚洲伊人午夜网| 免费无码又爽又刺激高潮视频| 国产日产欧产精品精品ai| 大帝a∨无码视频在线播放| 成人国产片女人爽到高潮| 九九视频在线观看视频6| 女被啪到深处喷水gif动态图| 国内老熟妇乱子伦视频| 久久精品国产99国产精品亚洲| 国产精品丝袜肉丝出水| 性欧美俄罗斯乱妇| 久久久久人妻精品一区三寸蜜桃| 免费夜色污私人影院在线观看| 久久久久久无码日韩欧美| 亚洲国产精品无码久久久不卡| 日本乱人伦在线观看| 国产素人在线观看人成视频| 亚洲精品午夜久久久伊人| 黑人巨大精品欧美黑寡妇| 中文字幕网伦射乱中文| 成人亚洲a片v一区二区三区日本 | 国产成+人+综合+亚洲欧美| 人妻av中文字幕久久|