在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FDFT1 Antibody, Biotin conjugated

FDFT1 Antibody, Biotin conjugated

  • 中文名稱：
    FDFT1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA008562LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FDFT1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FDFT1
  • 別名：
    DGPT antibody; ERG9 antibody; Farnesyl diphosphate farnesyltransferase antibody; Farnesyl-diphosphate farnesyltransferase antibody; FDFT_HUMAN antibody; FDFT1 antibody; FPP:FPP farnesyltransferase antibody; SQS antibody; Squalene synthase antibody; Squalene synthetase antibody; SS antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Squalene synthase protein (2-417AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway.
  • 基因功能參考文獻：
    1. The results indicate that the ennea-peptide CLSPHSMFC, tetra-peptides SMFC, CKTE, and WHQW can effectively inhibit Squalene Synthase activities (IC50 values equal to 64, 76, 87, and 90 muM, respectively) PMID: 26922723
    2. The minor allele in FDFT1 was associated with advanced fibrosis in the non-steatotic but not in the steatotic subgroup in patients with chronic hepatitis C. PMID: 23870067
    3. Up-regulation of SQS promotes metastasis of lung cancer by enhancing tumor necrosis factor-alpha receptor 1 and nuclear factor-kappaB activation and matrix metallopeptidase 1 expression. PMID: 25152164
    4. Several critical residues that are involved in binding of NADPH have been identified in the active site of squalene synthase. PMID: 24531458
    5. HCV infection increases FDFT1 protein level but not FDFT1 mRNA level. PMID: 24690320
    6. this finding yields a new method of colorimetric screening for the cellular activity of squalene synthases, which are major targets for cholesterol-lowering drugs. PMID: 24333579
    7. ABHD5, PGRMC1 and SQS are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically BCC with clear cell features. PMID: 23557589
    8. FDFT1 and its encoded enzyme, squalene synthase, may play an important role in prostate cancer development and its aggressive phenotypes. PMID: 22546838
    9. CTSB and FDFT1 are excluded as candidates for keratolytic winter erythema PMID: 21945151
    10. NASH is intimately related to fibrosis progression, the FDFT1 SNP is a good candidate for a link with inflammation and fibrosis. PMID: 21439984
    11. In multivariate models adjusted for age, body mass index, diabetes, waist/hip ratios, and levels of glycated hemoglobin, the NAFLD activity score was associated with the SNP rs2645424 on chromosome 8 in farnesyl diphosphate farnesyl transferase 1 (FDFT1) PMID: 20708005
    12. Results report the high-resolution x-ray structures of human farnesyl pyrophosphate synthase in complexes with risedronate and zoledronate, two of the leading nitrogen-containing bisphosphonates in clinical use. PMID: 16684881
    13. in prostate cancer cells SQS expression is enhanced by androgens, channeling intermediates of the mevalonate/isoprenoid pathway toward cholesterol synthesis PMID: 17483544
    14. lysine in codon 45 is conserved across 11 mammals and lies in an exonic splicing enhancer site, suggesting this coding variant in the squalene synthase gene influences plasma cholesterol levels, by affecting the intracellular production of cholesterol PMID: 18350552
    15. the liver X receptor alpha directly silencing the expression of two key cholesterologenic enzymes (lanosterol 14alpha-demethylase (CYP51A1), and squalene synthase (farnesyl diphosphate farnesyl transferase 1)) via novel negative LXR DNA response elements PMID: 18676367
    16. squalene synthase may be involved in the etiology of hypercholesterolemia PMID: 19054015
    17. FDFT1 rs7001819 showed no association with obesity, neither when analysing quantitative traits nor when performing case-control studies of obesity PMID: 19245693

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Phytoene/squalene synthase family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3629

    OMIM: 184420

    KEGG: hsa:2222

    STRING: 9606.ENSP00000220584

    UniGene: Hs.593928



主站蜘蛛池模板： 97超碰国产精品无码分类| 亚洲国产精品特色大片观看完整版| 亚洲有无码av在线播放| 久久男人av资源网站| 国产成人一区二区三区免费| 成年女人永久免费观看视频| 成a人片亚洲日本久久| 国产v综合v亚洲欧| 欧美日韩中文在线字幕视频| 窝窝午夜理论片影院| 熟女无套内射线观56| 国产精品久久久久久爽爽爽床戏| 午夜福利免费0948视频| 黄a大片av永久免费| 精品人妻系列无码人妻免费视频| 久久人妻国产精品| 日韩不卡1卡2卡三卡2021免费| 欧美性xxxxx极品老少| 一本一道精品欧美中文字幕| 久久亚洲中文无码咪咪爱| 丰满人妻被黑人连续中出| 999久久欧美人妻一区二区| 最新色国产精品精品视频| 午夜国产成人片在线播放| 成人丝袜激情一区二区| 波多野结衣一区二区三区高清av | 免费无码又爽又刺激软件下载| 亚洲精品中国国产嫩草影院美女| 疯狂做受xxxx高潮视频免费| 国产精品老熟女露脸视频| 亚洲精品国产一二三无码av| 天天躁日日躁狠狠躁视频2021| 国产v亚洲v天堂无码久久久| 亚洲人成77在线播放网站| 97丨九色丨国产人妻熟女| 亚洲欧美国产精品久久久久久久 | 18无码粉嫩小泬无套在线观看| 永久免费看mv网站入口亚洲| 8x福利精品第一导航| 四虎影库久免费视频| 国产精品十八禁在线观看|