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  4. FCRL5 Antibody, FITC conjugated

FCRL5 Antibody, FITC conjugated

  • 中文名稱：
    FCRL5兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA853494LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FCRL5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    BXMAS1 antibody; CD307 antigen antibody; CD307e antibody; Fc receptor homolog 5 antibody; Fc receptor like 5 antibody; Fc receptor-like protein 5 antibody; FcR-like protein 5 antibody; FcRH5 antibody; FcRL5 antibody; FCRL5_HUMAN antibody; Immune receptor translocation-associated protein 2 antibody; Immunoglobulin receptor translocation associated gene 2 protein antibody; Immunoglobulin superfamily receptor translocation associated gene 2 protein antibody; IRTA2 antibody; UNQ503/PRO820 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Fc receptor-like protein 5 protein (419-553AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.
  • 基因功能參考文獻(xiàn)：
    1. based on FCRL5 binding, we can discern distinct changes in the IgG2 molecule, including the disulfide isoform structure and charge variants related to deamidation. Since both IgG2 deamidation and conversion of disulfide isoforms occur in vivo, these findings elucidate the biological FCRL5 ligand. PMID: 29101848
    2. we found that FCRL5 expression is induced specifically upon BCR stimulation and dissected the molecular mechanism PMID: 27065451
    3. this study revealed that the FCRL5+ tissue-like memory subset responds poorly to multiple stimuli compared with the FCRL5- subset, as reflected by reduced calcium mobilization and blunted cell proliferation PMID: 27076679
    4. Data suggest that expression of FCRL5 (but not FCRL4) on surface of atypical (perhaps dysfunctional) memory B-Lymphocytes is up-regulated by exposure to Plasmodium falciparum antigens in subjects in Uganda where malaria is endemic. PMID: 25993340
    5. FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality. Recognition of undamaged IgG molecules by FCRL5 could allow B cells to engage recently produced Abs. PMID: 23616577
    6. FcRL5 binds all immunoglobulin (Ig)G isotypes with varied efficiency. PMID: 22491254
    7. Enhanced proliferation and downstream isotype expression upon FCRL5 stimulation could reflect a physiological role for FCRL5 in the expansion and development of antigen-primed B cells. PMID: 22028333
    8. Three of the FCRL5 tag SNPs, rs6667109, rs3811035 and rs6692977 showed association with Graves' disease. association with FCRL5 was secondary to linkage disequilibrium with the FCRL3, rs11264798 and rs10489678 SNPs. PMID: 20626413
    9. Characterization and comparison of the structure and B-cell expression pattern of the entire family of IRTA genes, which includes 5 members contiguously located on chromosome. PMID: 11929751
    10. IRTA2 is expressed on the surface of human lymphoma cell lines and hairy cell leukemia cells PMID: 15671532
    11. results identify FcRH5 as a novel, direct target of EBNA2 that may contribute to the development of Epstein-Barr virus-associated tumors PMID: 16439682
    12. IRTA2/FcRH5 may have a role in hairy cell leukemia PMID: 16681430
    13. Down-regulation of FCRL5 is associated with acute lymphoblastic leukemia. PMID: 18802695
    14. Single-nucleotide polymorphism in the FCRL5 gene and HLA-B27 is associated with ankylosing spondylitis. PMID: 19775371

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  • 相關(guān)疾病：
    A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32).
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, iso
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18508

    OMIM: 605877

    KEGG: hsa:83416

    STRING: 9606.ENSP00000354691

    UniGene: Hs.415950



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