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FCRL2 Antibody

  • 中文名稱:
    FCRL2兔多克隆抗體
  • 貨號:
    CSB-PA853454ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: FCRL2 antibody at 1.78µg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 56, 28, 21, 16, 23 kDa
      Observed band size: 56 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA853454ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA853454ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FCRL2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FCRL2
  • 別名:
    CD307b antibody; Fc receptor homolog 2 antibody; Fc receptor like protein 2 antibody; Fc receptor-like protein 2 antibody; FcR-like protein 2 antibody; FcRH2 antibody; FCRL 2 antibody; FcRL2 antibody; FCRL2_HUMAN antibody; IFGP family protein 4 antibody; IFGP4 antibody; Immunoglobulin receptor translocation associated 4 protein antibody; Immunoglobulin receptor translocation-associated protein 4 antibody; IRTA4 antibody; SH2 domain containing phosphatase anchor protein 1 antibody; SH2 domain-containing phosphatase anchor protein 1 antibody; SPAP1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Fc receptor-like protein 2 protein (20-100AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May have an regulatory role in normal and neoplastic B cell development.
  • 基因功能參考文獻:
    1. decreased FCRL4 expression and association of FCRL2 expression with inflammatory markers and disease activity suggested the contribution of these molecules to rheumatoid arthritis inflammatory processes. PMID: 27193470
    2. FCRL2 overexpression in B cells from Hashimoto and Graves disease patients compared to normal subjects. PMID: 25738996
    3. a negative immunomodulatory function for FCRL2 in the regulation of memory B cells. PMID: 21068405
    4. B-CLL patients with high FCRL2 expression had a significantly longer treatment-free survival & overall survival than those with low FCRL2. PMID: 19682311
    5. FCRL2 has robust predictive value for determining IGHV gene mutation status and clinical progression and thus may further improve prognostic definition in chronic lymphocytic leukemia. PMID: 18314442
    6. Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia. PMID: 18704934
    7. Down-regulation of FCRL2 is associated with acute lymphoblastic leukemia. PMID: 18802695

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  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone
  • 數據庫鏈接:

    HGNC: 14875

    OMIM: 606509

    KEGG: hsa:79368

    STRING: 9606.ENSP00000355157

    UniGene: Hs.437393



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