在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FBXW11 Antibody

  • 中文名稱:
    FBXW11兔多克隆抗體
  • 貨號:
    CSB-PA008521GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    beta Transducin Repeat Containing Protein 2 antibody; BTRC2 antibody; BTRCP2 antibody; F-box and WD repeats protein beta-TrCP2 antibody; F-box and WD-40 Domain Protein 1B antibody; F-box Protein FBW1B antibody; F-box/WD repeat-containing protein 11 antibody; F-box/WD repeat-containing protein 1B antibody; FBW1B antibody; FBW1B_HUMAN antibody; FBXW11 antibody; FBXW1B antibody; Homologous to Slimb protein antibody; HOS antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human FBXW11
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis. Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2.; (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
  • 基因功能參考文獻:
    1. SCF(FBXW11) bound, polyubiquitylated, and destabilized RAPGEF2, a guanine nucleotide exchange factor that activates the small GTPase RAP1 PMID: 25332235
    2. Data indicate that miR-106b-25 cluster (miR-106b, miR-93 and miR-25) targets the 3'UTR of the beta-TRCP2 transcript and increases the expression of Snail. PMID: 23611780
    3. Knockdown of beta-TrCP1 and beta-TrCP2 attenuated the K48-linked ubiquitination and degradation of IRAK1. PMID: 22851693
    4. two splice variants of beta-transducin repeat containing protein 2 (BTRCP2) localise exclusively to either the nucleus or the cytosol. PMID: 21138764
    5. FBXW11 may be the most likely candidate gene for the Holoprosencephaly and prexial polydactyly phenotype. PMID: 16865294

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 數據庫鏈接:

    HGNC: 13607

    OMIM: 605651

    KEGG: hsa:23291

    STRING: 9606.ENSP00000265094

    UniGene: Hs.484138



主站蜘蛛池模板: 国产在线精品一区二区三区不卡| 国产av国片精品有毛| 九九综合va免费看| 亚洲色婷婷一区二区三区| 在线天堂中文www官网| 最新国产久免费视频在线观看| 久久av高潮av无码av| 欧美亚洲国产一区二区三区| 色老久久精品偷偷鲁| 欧美激情猛片xxxⅹ大3| 2022一本久道久久综合狂躁| 人妻少妇精品中文字幕av蜜桃| av无码久久久久久不卡网站| 天天做天天爱天天要天天| 国产作爱激烈叫床视频| 成 人 免费观看网站| 日本人妻人人人澡人人爽| 久久精品国产99精品亚洲| 亚洲国产精品无码久久一区二区| 精品一区二区三区在线播放视频 | 天堂网www中文在线| 精品国产一二三产品区别在哪| 2021亚洲国产成a在线| www一区二区www免费| 男人扒开女人双腿猛进视频| 娜娜麻豆国产电影| 制服丝袜另类专区制服| 一线二线三线天堂| 国产精品青青在线麻豆| 在线天堂资源www中文| 久久综合噜噜激激的五月天| 一二三区乱码不卡手机版| 性无码专区一色吊丝中文字幕| 国产在线视频www色| 国产精品日韩av在线播放| 中文字幕乱人伦高清视频| 久久99精品久久久久久9蜜桃| 精品国产三级在线观看| av无码国产在线观看岛国| 中文字幕人妻丝袜成熟乱| 乱人伦人妻中文字幕无码久久网|